2017
DOI: 10.1371/journal.pone.0181940
|View full text |Cite
|
Sign up to set email alerts
|

Biochemical characterization and comparison of aspartylglucosaminidases secreted in venom of the parasitoid wasps Asobara tabida and Leptopilina heterotoma

Abstract: Aspartylglucosaminidase (AGA) is a low-abundance intracellular enzyme that plays a key role in the last stage of glycoproteins degradation, and whose deficiency leads to human aspartylglucosaminuria, a lysosomal storage disease. Surprisingly, high amounts of AGA-like proteins are secreted in the venom of two phylogenetically distant hymenopteran parasitoid wasp species, Asobara tabida (Braconidae) and Leptopilina heterotoma (Cynipidae). These venom AGAs have a similar domain organization as mammalian AGAs. The… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

0
11
0

Year Published

2018
2018
2024
2024

Publication Types

Select...
7
2

Relationship

1
8

Authors

Journals

citations
Cited by 9 publications
(11 citation statements)
references
References 66 publications
0
11
0
Order By: Relevance
“…RhoGAP (LhGAP2) 10B28 1 Aspartylglucosaminidase 23 An aspartylglucosaminidase (AGA), a usually lysosomal enzyme involved in the catabolism of N-linked oligosaccharides of glycoproteins, was found to be abundant in L. heterotoma venom as well as in the venom of Asobara tabida (Moreau et al, 2004;Vinchon et al, 2010;Colinet et al, 2013a;Coulette et al, 2017).…”
Section: Discussionmentioning
confidence: 99%
“…RhoGAP (LhGAP2) 10B28 1 Aspartylglucosaminidase 23 An aspartylglucosaminidase (AGA), a usually lysosomal enzyme involved in the catabolism of N-linked oligosaccharides of glycoproteins, was found to be abundant in L. heterotoma venom as well as in the venom of Asobara tabida (Moreau et al, 2004;Vinchon et al, 2010;Colinet et al, 2013a;Coulette et al, 2017).…”
Section: Discussionmentioning
confidence: 99%
“…Further, while A. tabida is the most closely related of the well-studied parasitoid species to Asobara sp. AsDen , its venom has been shown to cause paralysis and inhibit host development with only limited immune-suppressive effects [ 36 , 75 , 76 , 77 , 78 , 79 ]. This is not entirely unexpected, as other closely related parasitoid species have distinct virulence strategies and venom composition [ 37 , 38 , 80 ].…”
Section: Discussionmentioning
confidence: 99%
“…Further, while A. tabida is the most closely related of the wellstudied parasitoid species to Asobara sp. AsDen, its venom has been shown to cause paralysis and inhibit host development with only limited immune-suppressive effects [36,[75][76][77][78][79]. This is not entirely unexpected, as other closely related parasitoid species have distinct virulence strategies and venom composition [37,38,80].…”
Section: Discussionmentioning
confidence: 99%