Biochemical characteristics and calcium and PTH levels of patients with high normal and elevated serum 25(OH)D levels in Turkey: DeVIT-TOX survey

Pekkolay, Zafer; Yavuz, Dilek Gogas; Saygılı, Emre Sedar; Değertekin, Ceyla Konca; Topaloğlu, Ömercan; Önder, Çağatay Emir; Soylu, Hikmet; Taşkaldıran, Işılay; Pazir, Ayse Esen; Uğur, Kader; Tanrikulu, Seher; Fırat, Sevde Nur; Atak, Burcu Meryem; Batman, Adnan; Omma, Tülay; Çağıltay, Eylem; Özdemir, Nilüfer; Altuntaş, Seher Çetinkaya; Imga, Narin Nasiroglu; Karakılıç, Ersen; Hekimsoy, Zeliha; Kılınç, Faruk; Yay, Adnan; Eroğlu, Mustafa; Tuzcu, Alpaslan

doi:10.1007/s11657-021-01002-8

Cited by 1 publication

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“…Gorman et al also found that high-dose intramuscular vitamin D provides longlasting moderate increases in the serum 25-hydroxvitamin D level and short-term changes in the plasma calcium level (36). In addition, previous studies found that vitamin D intake over the recommended dose is often associated with a high serum 25(OH)D level and mostly not associated with symptoms of hypercalcemia (37). A sandwich enzyme-linked immunosorbent assay (ELISA) for quantification of the N-terminal propeptide of human procollagen type I (PINP) utilizing purified alpha 1chain specific rabbit antibodies is described (38).…”

Section: Discussionmentioning

confidence: 96%

Effect of a high vs. standard dose of vitamin D3 supplementation on bone metabolism and kidney function in children with chronic kidney disease

Feng

et al. 2022

Front. Pediatr.

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We investigated the effects of high- vs. standard-dose vitamin D supplementation on kidney function and bone metabolism in children with chronic kidney disease (CKD). Children were randomized to receive one of two formulations: 75 participants received 2,000 IU/D of oral supplementation of vitamin D, while 75 participants received 400 IU/d for a minimum of 4 months. We investigated the effects of vitamin D supplementation on kidney-related indicators and bone metabolism-related indicators at different doses. A total of 158 participants were screened, among whom 150 met the inclusion criteria. The indicators of chronic kidney disease such as eGFR and serum uric acid were negatively correlated with the 25(OH)D level and BMD. Serum 25(OH)D and osteocalcin levels were positively correlated with spine BMD. The standard dose of vitamin D can improve the serum uric acid level, but high doses of vitamin D supplementation had no significant effect on the serum uric acid level. High doses of vitamin D supplementation can also improve the alkaline phosphatase level. When comparing the results of different doses of vitamin D supplementation, it was found that high-dose vitamin D supplementation did not improve bone density in the spine and femur neck relative to the standard dose of vitamin D but improved hypocalcemia and N-terminal propeptide of the human procollagen type I (PINP) level. Among the children with clinical kidney disease, high-dose vitamin D treatment for 4 months resulted in statistically significant improvement in kidney function but no significant difference in bone metabolism compared with the standard-dose vitamin D treatment.

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Section: Discussionmentioning

confidence: 96%

Effect of a high vs. standard dose of vitamin D3 supplementation on bone metabolism and kidney function in children with chronic kidney disease

Feng

et al. 2022

Front. Pediatr.

View full text Add to dashboard Cite

show abstract

Biochemical characteristics and calcium and PTH levels of patients with high normal and elevated serum 25(OH)D levels in Turkey: DeVIT-TOX survey

Cited by 1 publication

References 30 publications

Effect of a high vs. standard dose of vitamin D3 supplementation on bone metabolism and kidney function in children with chronic kidney disease

Effect of a high vs. standard dose of vitamin D3 supplementation on bone metabolism and kidney function in children with chronic kidney disease

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