Biochemical changes in the brain of hemiplegic migraine patients measured with 7 tesla ¹H-MRS

Abstract

We found a decreased cerebellar tNAA/tCre ratio that might serve as an early biomarker for neuronal dysfunction and/or loss. This is the first high-spectral resolution 7 tesla (1)H-MRS study of interictal biochemical brain changes in hemiplegic migraine patients.

Metabolic assessment of a migraine model using relaxation‐enhanced 1H spectroscopy at ultrahigh field

“…Contrary to earlier some clinical reports from the interictal period (6, 12, 40, 62), the present findings do not display a significant deviation in the trend attributed to NAA, and the levels remained relatively consistent in the NTG versus saline injected rats, which is more in line with the majority of clinical 1 H MRS migraine studies (16). NAA is widely held as a marker for neuronal and axonal integrity and is indicative of mitochondrial functioning as it is synthesized in neural mitochondria (12, 62). Physiologically, the changes in NAA seen in migraine and consequent mitochondrial disruption could be a result of long-term or repeated migraine.…”

Structural Changes in the Cerebrum, Cerebellum and Corpus Callosum in Migraine Patients

“…This relationship between a migraine and decrease cerebellum volume leads to cognitive and motor function loss over time. Zielman et al stated that a migraine caused atrophy in the brain and led to cerebellar neural damage [12]. In migraine patients, vestibulocochlear dysfunction and balance problems often arise because of neuronal loss in the cerebellum [13].…”

Magnetic Resonance Imaging in Pediatric Migraine

“…Creatine provides a measure of energy stores. A single case study is not convincing to argue that this is typical of pediatric migraineurs, although several studies of migraine in adults have shown decreased NAA in various regions of the brain; [99][100][101][102][103] one study observed an increase in NAA in the pons in episodic migraineurs, 104 and many studies have not observed any differences in NAA levels in various regions of the brain. 84,85,97,[105][106][107][108][109][110][111][112][113][114] Location, in addition to type of migraine, and migraine severity may also confound results and explain some of these discrepancies.…”