Biochemical Changes in Chronic Renal Failure Pre and Post Hemodialysis

Sarhat, Entedhar R.; Murtadha, Nawal Abdullah

doi:10.17265/2162-5298/2016.04.003

Cited by 7 publications

(5 citation statements)

References 16 publications

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“…As the excretory function of kidney is impaired, urea and Cr excretion is hampered leading to its increased levels in blood (12), so that our results showed that statistical significant increase of urea and creatinine is as a result of administration of indomethacin which may indicate kidney injury, with resultant reduced glomerular filtration. The results of this study disagree with the findings of KIM et al (13) which found that indomethacin did not significantly alter the plasma creatinine clearance. BOLAT et al (14) indicate that NSAIDs induced nephrotoxicity may be due to the inhibitory effect of these drugs on prostaglandin synthesis, thus causing kidney ischemia.…”

Section: Discussioncontrasting

confidence: 99%

Histological and Biochemical Changes of Rats kidneys post Indomethac in Administration

2023

JPTCP

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Non-steroidal Anti-inflammatory Drugs (NSAIDs) are one of the most widely used drugs in medicine and their uses has dramatically increased in recent years. They are a class of drugs that reduce pain and lowering the body temperature. The metabolism and excretion of indomethacin was conducted in kidney, so as a result, biochemical parameter and kidney tissues may altered. The present study was designed to evaluate the biochemical, and histological changes induced by indomethacin on the rat's kidney , Thirty adult male albino Sprague-Dawley rats were used in this experimental study. Rats were divided into three equal groups [ Ten in each]. All rats were kept in a quite non stressful environment, provided with food ad libitum and free access to water. Normal saline (1 ml) was given intramuscularly for the control group (I). Experimental groups (II, and III) were injected with indomethacin intramuscularly equivalent to 5 and 10 mg/kg body weight/day respectively for two weeks. Results revealed that indomethacin administration significantly increased the levels of blood urea, uric acid and creatinine when compared with control rats. This study confirmed the risk of increased oxidative stress, and nephrotoxicity due to indomethacin administration. Although indomethacin is reported to be effective in pain management, its toxicity should be kept in mind

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Section: Discussioncontrasting

confidence: 99%

Histological and Biochemical Changes of Rats kidneys post Indomethac in Administration

2023

JPTCP

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“…Urea and creatinine levels serve as crucial biomarkers in both diagnosing and tracking the progression of renal failure. As a byproduct of protein metabolism, urea levels tend to rise in the blood of patients with renal failure, ultimately leading to the development of uremia [18][19][20].…”

Section: Discussionmentioning

confidence: 99%

Effect of Dialysis on Biochemical Parameters in Chronic Renal Failure Patients: A Cross-sectional Study

Albalawi

Dera

Rajagopalan

et al. 2023

IJBcRR

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Aims: Hemodialysis uses a semi-permeable membrane and electrochemical gradient to balance fluid and essential nutrient levels in the body. The kidneys perform this function in healthy individuals. The study aims to analyze the biochemical parameters of patients undergoing hemodialysis. Study Design: Cross-sectional study. Place and Duration of Study: The study enrolled 130 patients with chronic renal failure undergoing hemodialysis in King Khalid Hospital Tabuk, Saudi Arabia between January 2023 and February 2023. Methodology: The study applied correlation analysis to determine the nature of the relationships between the biochemical parameters during hemodialysis. Descriptive statistics were also used to determine the mean concentrations for the parameters during hemodialysis. Results: The concentrations of urea dropped from 45.12mmol/l from week one to 5.74mmol/l in week four. While the concentration of creatinine dropped from 761.53umol/l from week one to 160.60umol/l in week four. The study used correlation analysis to establish that there was a statistically significant strong positive correlation between urea and creatinine, calcium, iron, total iron binding capacity (TIBC), and albumin had their concentrations vary during dialysis weeks, with their concentrations increasing during some weeks and decreasing during others. It was also determined that there was a significant negative correlation between urea and TIBC. Conclusion: The study established that there was a significant reduction in the concentration of urea and creatinine during the fourth week of dialysis compared to the first week of dialysis. Therefore, dialysis helps to remove toxic waste products from the bloodstream.

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“…Serum urea, uric acids and creatinine levels are important biomarkers as they play a pivotal role in diagnosis and followup of kidney failure. Urea, one of the by-products of protein metabolism, accumulates in the blood of patients with kidney failure and causes uremia [17]. Urea nitrogen is a normal waste nitrogen product found in blood that comes from the breakdown of protein from foods.…”

Section: Discussionmentioning

confidence: 99%

Safety and risk assessment of methanol extract of Ocimum gratissimum leaf on Wistar rats

Dasofunjo K,

Odu F,

Nnamani VI

et al. 2023

GSC Biol. Pharm. Sci.

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Methanol extract of Ocimum gratissimum was investigated for its effects on Wistar rats using some kidney and liver functional indices as ‘markers’. Twenty- eight (28) albino rats weighing 180-200 g was randomly assigned into four groups (A-D) of seven animals each. Animals in groups B-D was orally administered on daily basis with 0.5 ml of the extract corresponding to 50,100 and 200 mg/kg body weight of the extract respectively for 14 days while those in the control group received orally 0.5 ml of distilled water. Rats in all the groups were sacrificed 24 hours after the completion of their respective doses and serum, liver and kidney tissue samples were collected for biochemical parameters. The extract significantly (p<0.05) decreased serum, liver and kidney ALP, AST and ALT. The extract also significantly (p<0.05) reduced serum urea, uric acid and creatinine. Contrastingly, the extract significantly (p < 0.05) increase in serum albumin, globulin and total protein respectively when compared with the normal control at 50, 100 and 200 mg/kg body weight respectively. The effect of administration of the extract on serum Na+, K+, Cl- and HCO3- ions shows a significant (p<0.05) decrease when compared with the normal control with the exception of an increase in K+ ion concentration at 200 mg/kg bwt when compared with the normal control. The biochemical alterations from this result suggest that the extract of Ocimum gratissimum may induce hyponatremia and hypokalaemia at high dosage possibly by altering the Na + /H – exchanger with aldosterone without causing assault or injury to the hepatic, nephrotic and /or tubular function.

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Biochemical Changes in Chronic Renal Failure Pre and Post Hemodialysis

Cited by 7 publications

References 16 publications

Histological and Biochemical Changes of Rats kidneys post Indomethac in Administration

Histological and Biochemical Changes of Rats kidneys post Indomethac in Administration

Effect of Dialysis on Biochemical Parameters in Chronic Renal Failure Patients: A Cross-sectional Study

Safety and risk assessment of methanol extract of Ocimum gratissimum leaf on Wistar rats

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