Biochemical Bone Turnover Markers in Postmenopausal Women in Calabar Municipality

Usoro, Chinyere Adanna Opara; Onyeukwu, Cynthia Uzoma; Nsonwu, Augusta Chinyere

doi:10.3923/ajb.2007.130.135

Cited by 12 publications

(9 citation statements)

References 15 publications

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“…This study observed significant increase in parathyroid hormone, calcium and phosphate but decreased oestrogen in post-menopausal women compared with pre-menopausal women. This is in agreement with the works which reported elevated levels of parathyroid hormone, calcium and phosphate in post-menopausal women [18,19,20] . Their reports also showed that menopause brings about a decline in the production of oestrogen and also implicated elevated levels of calcium and inorganic phosphate in post-menopausal women.…”

Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 93%

“…In this study, the serum calcium level was significantly higher in post-menopausal women compared with pre-menopausal women which agrees with previous findings [18,20] . Serum calcium can increase in post-menopausal women due to the fact that ageing and menopause induces low levels of oestrogen and increased levels of parathyroid hormone leading to the release of calcium ions in the bones, causing elevated levels of the ions in the serum [20] . It has been shown that higher levels of serum calcium can be noticed in women in the early ages of menopause (which may be the reason for the levels obtained in this study) but becomes lower at the later ages and this can be due to a decrease in intestinal absorption of calcium [2] .…”

Section: Discussionsupporting

confidence: 93%

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Assessment of the Levels of Parathyroid Hormone, Oestrogen and Selected Bone Minerals in Menopausal Women

Oluboyo¹,

Anaenye²,

Oluboyo³

et al. 2018

Am. J. Biomed. Sci.

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Menopause is associated with various physiological and biochemical changes that have effects on bone minerals and their metabolism. There have been a lot of complaints about bone pains and bone related problems especially among middle aged women. Thus, the work was designed to assess and compare the levels of parathyroid hormone (PTH), oestrogen and selected bone minerals (calcium and phosphate) in preand post-menopausal women. A total of one hundred subjects were investigated. They comprised fifty premenopausal women within the ages of 20 years and 45 years and fifty post-menopausal women within the ages of 50 years and 65 years. The levels of parathyroid hormone, oestrogen, calcium and phosphate were measured in the subjects. Parathyroid hormone and oestrogen were analyzed using enzyme immunoassay technique while calcium and phosphate were analyzed using spectrophotometric method. The results showed that parathyroid hormone, calcium and phosphate were significantly increased (p<0.05) while there was decrease in oestrogen in post-menopausal women compared with premenopausal women. PTH and oestrogen correlated significantly at (p<0.01) in both pre-and post menopause. This study concluded that postmenopausal women have increased serum levels of parathyroid hormone, calcium and phosphate but decreased serum level of oestrogen. Significant positive correlation exists between PTH and oestrogen in both pre-and post menopause but no significant relationship between PTH and oestrogen with calcium and phosphate.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

See 1 more Smart Citation

Assessment of the Levels of Parathyroid Hormone, Oestrogen and Selected Bone Minerals in Menopausal Women

Oluboyo¹,

Anaenye²,

Oluboyo³

et al. 2018

Am. J. Biomed. Sci.

View full text Add to dashboard Cite

show abstract

“…Calcium and phosphorus are the two cardinal macro minerals required for bone building and therefore these correlations are predictable. No signi cant variation was observed in these parameters among groups with various years since menopause (24). However, in parallel to our ndings higher phosphorus, calcium, and ALP activity have been demonstrated in early menopause (25).…”

Section: Discussionsupporting

confidence: 87%

The Impact of Duration of Menopause on Bone Metabolism in Detecting and Preventing Osteoporotic Fractures

Rai

Hegde²,

Rai

et al. 2021

Preprint

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Background: Menopause accelerates bone loss after 10 years of cessation of the menstrual cycle causing osteoporosis. Hip fractures among postmenopausal women escalate morbidity and mortality in these women. Objective: The study was done to evaluate the effect of duration of menopause on BTMs so that it could detect post-menopausal osteoporosis at the earliest and predict the fracture risk Materials and Methods: The study was conducted in a tertiary hospital in Mangalore on 100 postmenopausal women. The duration of menopause was divided into quartiles. Evaluation and correlation of serum osteocalcin, urinary hydroxyproline, BMI, calcium, phosphorous and alkaline phosphatase was done on the duration of menopause. The subjects comprised 50 osteoporotic and 50 non-osteoporotic post-menopausal women. Continuous variables were represented as median and interquartile ranges. Comparison between two groups was done using the Mann Whitney U test. Comparison between more than two groups was done using the Kruskal Wallis test. The correlation was done using spearman’s correlation test. Statistical significance was considered at p<0.05. Results: Serum osteocalcin levels significantly declined and urinary hydroxyproline levels elevated between quartiles of duration of menopause in the entire study group and in osteoporotic women. (p<0.001). There was no significant difference in osteocalcin and hydroxyproline levels between the quartiles in the fracture group. 82% of the osteoporotic had >15 YSM. Conclusion: Osteocalcin levels plateaued after 8years of menopause and started decreasing after 15 YSM. Osteoporotic fractures were higher in more than 15 YSM and the osteocalcin level was 2.47 ng/ml in this quartile. There is no significant difference in osteocalcin levels in those with fractures, indicating no significance of screening for serum osteocalcin levels once the fractures have occurred. Hence concluding that the duration of menopause is the key indicator for osteoporosis and serum osteocalcin is a potent biomarker for detection of the risk of fracture. Monitoring of serum osteocalcin levels(<2.55ng/ml) after 8 years of menopause is very essential for early prophylactic treatment in order to prevent osteoporotic fractures and the burden associated with it. KEYWORDS: Duration of menopause, osteocalcin, quartiles, urinary hydroxyproline, osteoporotic fractures

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“…Versura et al [9] study reported a decrease in total protein and an increase in albumin in early dry eye patients when compared to non-dry eye patients. We studied a different population (postmenopausal women) and in this population, it has been found that menopause and aging alters metabolism of total protein and albumin [32,33,34].…”

Section: Resultsmentioning

confidence: 99%

Effect of dry eye diseases on the level of Protein and Lipids in Tears of Postmenopausal Women.

Shuaibu¹,

Akinlabi²

2021

JCSN

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The study is aimed at investigating the effect of dry eye disease on the level of protein and lipids in tears of postmenopausal women. The study was carried out on 33 postmenopausal women with dry eye symptoms and 22 postmenopausal women that were asymptomatic. The ocular surface disease index (OSDI) questionnaire classified participants as being symptomatic or asymptomatic of dry eye. Tear stability and tear volume were assessed with Fluorescein Tear Break up Time (FBUT) and Schirmer’s test respectively. Tears were analysed for protein (total protein, albumin, and globulin) and lipid (cholesterol and triglycerides). The mean total protein for Dry Eye (DE) was higher than that for Non-dry eye (NDE). Albumin and globulin were also higher for the DE group when compared to the NDE group. These were however, not statistically significant (p > 0.05). There was also no significant difference in triglycerides and cholesterol between DE and NDE. There was no significant correlation between clinical signs (tear volume and tear breakup time) and total protein, albumin, globulin cholesterol and triglycerides in the NDE and DE eye groups. The study shows that proteins and lipids do not change in postmenopausal women irrespective of the presences of dry eye disease.

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Biochemical Bone Turnover Markers in Postmenopausal Women in Calabar Municipality

Cited by 12 publications

References 15 publications

Assessment of the Levels of Parathyroid Hormone, Oestrogen and Selected Bone Minerals in Menopausal Women

Assessment of the Levels of Parathyroid Hormone, Oestrogen and Selected Bone Minerals in Menopausal Women

The Impact of Duration of Menopause on Bone Metabolism in Detecting and Preventing Osteoporotic Fractures

Effect of dry eye diseases on the level of Protein and Lipids in Tears of Postmenopausal Women.

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