Biochemical blood parameters of patients with aleutian mink disease under the influence of alloferon

Abstract

Fur farming in Russia can be considered one of the most profitable industries. However, outbreaks of infectious diseases in animal farms, in the difficult conditions of the global financial crisis, cause irreparable economic damage, which negatively affects the prospects for the development of the industry. One of these diseases is the Aleutian Mink disease, which entails enormous losses associated with the lack of treatment and prevention. To date, the use of interferon inducers is considered a promising direction in the fight against viral diseases of animals. The objects of the study were mink of 30-day-old sapphire breed, spontaneously infected with the Aleutian disease virus. Two groups of 50 animals (25 females and 25 males) each were formed using the method of analog groups. The minks of the experimental group were subcutaneously injected with alloferon at a dose of 0.5 mg per head twice with an interval of 6 days. The control group animals were injected with saline solution (NaCl 0.9%) in the same dosing regimen. The biochemical parameters of blood were taken into account after 1 month of the experiment. Our studies have shown that in experimental animals the blood content of total protein was lower by 19.6%, globulins by 24.4%, urea levels were 2 times lower, creatinine values were 1.5 times, the amount of ALT and AST were 2.5 and 1.6 times lower, respectively. The obtained results of a biochemical study may indicate an improvement in metabolic processes in experimental individuals, which contributes to an increase in the productive qualities of sick animals. As a result of the conducted research, it can be concluded that it is advisable to use drugs based on alloferon for mink patients with viral plasmocytosis in order to reduce the economic damage from the Aleutian mink disease.