Biochemical basis of alphamethrin resistance in different life stages ofAnopheles stephensistrains of Bangalore, India

Hariprasad, T. P. N.; Shetty, N.J.

doi:10.1002/ps.4194

Cited by 5 publications

(12 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…aegypti larvae prior to treatment with P. crispum oil demonstrated significantly higher levels of some detoxifying enzymes, such as GSTs, α-/β-ESTs, ACP and MFO in resistant PMD-R and/or UPK-R, than those in susceptible MCM-S. These findings were in agreement with those of many biochemical studies, which evaluated various pest species in either laboratory or field populations, and demonstrated increased levels of detoxifying enzymes such as GSTs [48,49], α-/β-ESTs [29,[50][51][52][53], ACP [54,55], and MFO [56][57][58] [15,59], and elevation of enzyme activity implicate an enhancer in the tolerance of mosquitoes to insecticides [50,51,60,61]. In consequence, resistance to some insecticides has been linked to an increment in insecticide metabolism through the up-regulation or structural changes of detoxifying enzymes [62,63].…”

Section: Resultssupporting

confidence: 84%

Biochemical Effects of Petroselinum crispum (Umbellifereae) Fruit Oil on the Pyrethroid Susceptible and Resistant Strains of Aedes aegypti (Diptera: Culicidae)

Intirach¹,

Junkum²,

Lumjuan³

et al. 2018

Preprint

View full text Add to dashboard Cite

As part of the ongoing screening research for local edible plants in Thailand, Petroselinum crispum fruit oil was considered as a potential bioinsecticide with proven antimosquito activity against both the pyrethroid susceptible and resistant strains of Aedes aegypti. Due to the comparative mosquitocidal efficacy on these mosquitoes, this plant oil is promoted as a natural alternative and attractive candidate for further study in monitoring resistance of mosquito vectors. Therefore, the aim of this study was to evaluate the impact of P. crispum oil on the biochemical characteristics of the target mosquito larvae of Ae. aegypti, by determining quantitative changes of key enzymes responsible for xenobiotic detoxification, including glutathione-S-transferases (GSTs), α- and β-esterases (α-/β-ESTs), acetylcholinesterase (AChE), acid and alkaline phosphatases (ACP and ALP) and mixed-function oxidases (MFO). Three populations of Ae. aegypti, comprising the pyrethroid susceptible Muang Chiang Mai-susceptible (MCM-S) strain and the pyrethroid resistant Pang Mai Dang-resistant (PMD-R) and Upakut-resistant (UPK-R) strains, were used as test organisms. Biochemical study of Ae. aegypti larvae prior to treatment with P. crispum oil revealed that apart from AChE, the baseline activity of most defensive enzymes, such as GSTs, α-/β-ESTs, ACP, ALP and MFO, in resistant UPK-R or PMD-R, was higher than that determined in susceptible MCM-S. However, after 24-h exposure to P. crispum oil, the pyrethroid susceptible and resistant Ae. aegypti showed similarity in biochemical features, with alterations of enzyme activity in the treated larvae, as compared to the controls. A significant increase in the activity levels of GSTs, α-/β-ESTs, ACP and ALP was recorded in all strains of P. crispum oil-treated Ae. aegypti larvae, whereas MFO and AChE activity in these mosquitoes was decreased. The recognizable larvicidal capability on pyrethroid resistant Ae. aegypti, and the inhibitory effect on AChE and MFO, emphasized the potential of P. crispum oil as an attractive alternative application for management of mosquito resistance in current and future control programs.

show abstract

Section: Resultssupporting

confidence: 84%

Biochemical Effects of Petroselinum crispum (Umbellifereae) Fruit Oil on the Pyrethroid Susceptible and Resistant Strains of Aedes aegypti (Diptera: Culicidae)

Intirach¹,

Junkum²,

Lumjuan³

et al. 2018

Preprint

View full text Add to dashboard Cite

show abstract

“…The species is resistant to malathion in Delhi, West Bengal, Goa, Gujarat, Rajasthan, and Karnataka, susceptible in Kerala and Maharashtra, and resistant to be confirmed in Madhya Pradesh. To deltamethrin, the species is resistant in Karnataka, resistant to be confirmed in Gujarat but susceptible in Kerala, Delhi, Uttar Pradesh, West Bengal and Rajasthan [ 31 – 33 , 36 , 39 – 41 , 79 , 82 , 83 ]. In a recent study in Sri Lanka, the species is resistant to DDT, malathion and deltamethrin [ 55 ].…”

Section: Resultsmentioning

confidence: 99%

“…stephensi [ 90 , 91 ]. In India, the involvement of different enzyme groups including esterases, GSTs and cytochrome p450s as well as site insensitivity mechanism of kdr west and east alleles was revealed [ 31 , 33 – 36 , 38 , 39 , 47 , 48 ]. The site insensitivity resistance mechanisms in An.…”

Section: Resultsmentioning

confidence: 99%

“…Resistance to several insecticides of all major classes has been reported in Anopheles stephensi in other countries of the WHO Eastern Mediterranean Region (EMR), including Saudi Arabia [21,22], Iraq [23,24], Afghanistan [25][26][27][28], and Pakistan [29,30]. Resistance to DDT, dieldrin, malathion, and recently pyrethroid insecticides, was reported from different states of India [31][32][33][34][35][36][37][38][39][40][41].…”

Section: Introductionmentioning

confidence: 99%

“…Several mechanisms including metabolic and insecticide target site insensitivity are involved in insecticide resistance in An. stephensi from different countries, each of which has its own operational significance in vector control [ 26 – 28 , 31 , 33 – 36 , 38 , 39 , 42 , 47 , 48 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Evolution of insecticide resistance and its mechanisms in Anopheles stephensi in the WHO Eastern Mediterranean Region

Enayati

Hanafi‐Bojd

Sedaghat

et al. 2020

Malar J

View full text Add to dashboard Cite

Background: While Iran is on the path to eliminating malaria, the disease with 4.9 million estimated cases and 9300 estimated deaths in 2018 remains a serious health problem in the World Health Organization (WHO) Eastern Mediterranean Region. Anopheles stephensi is the main malaria vector in Iran and its range extends from Iraq to western China. Recently, the vector invaded new territories in Sri Lanka and countries in the Horn of Africa. Insecticide resistance in An. stephensi is a potential issue in controlling the spread of this vector. Methods: Data were collated from national and international databases, including PubMed, Google Scholar, Scopus, ScienceDirect, SID, and IranMedex using appropriate search terms. Results: Indoor residual spaying (IRS) with DDT was piloted in Iran in 1945 and subsequently used in the malaria eradication programme. Resistance to DDT in An. stephensi was detected in Iran, Iraq, Pakistan, and Saudi Arabia in the late 1960s. Malathion was used for malaria control in Iran in 1967, then propoxur in 1978, followed by pirimiphosmethyl from 1992 to 1994. The pyrethroid insecticide lambda-cyhalothrin was used from 1994 to 2003 followed by deltamethrin IRS and long-lasting insecticidal nets (LLINs). Some of these insecticides with the same sequence were used in other malaria-endemic countries of the region. Pyrethroid resistance was detected in An. stephensi in Afghanistan in 2010, in 2011 in India and in 2012 in Iran. The newly invaded population of An. stephensi in Ethiopia was resistant to insecticides of all four major insecticide classes. Different mechanisms of insecticide resistance, including metabolic and insecticide target site insensitivity, have been developed in An. stephensi. Resistance to DDT was initially glutathione S-transferase based. Target site knockdown resistance was later selected by pyrethroids. Esterases and altered acetylcholinesterase are the underlying cause of organophosphate resistance and cytochrome p450s were involved in pyrethroid metabolic resistance. Conclusions: Anopheles stephensi is a major malaria vector in Iran and many countries in the region and beyond. The species is leading in terms of development of insecticide resistance as well as developing a variety of resistance mechanisms. Knowledge of the evolution of insecticide resistance and their underlying mechanisms, in particular, are important to Iran, considering the final steps the country is taking towards malaria elimination, but also to other countries in the region for their battle against malaria. This systematic review may also be of value to countries and territories newly invaded by this species, especially in the Horn of Africa, where the malaria situation is already dire.

show abstract

Possible potential spread of Anopheles stephensi, the Asian malaria vector

Liu,

Wang,

et al. 2024

BMC Infect Dis

View full text Add to dashboard Cite

Background Anopheles stephensi is native to Southeast Asia and the Arabian Peninsula and has emerged as an effective and invasive malaria vector. Since invasion was reported in Djibouti in 2012, the global invasion range of An. stephensi has been expanding, and its high adaptability to the environment and the ongoing development of drug resistance have created new challenges for malaria control. Climate change is an important factor affecting the distribution and transfer of species, and understanding the distribution of An. stephensi is an important part of malaria control measures, including vector control. Methods In this study, we collected existing distribution data for An. stephensi, and based on the SSP1-2.6 future climate data, we used the Biomod2 package in R Studio through the use of multiple different model methods such as maximum entropy models (MAXENT) and random forest (RF) in this study to map the predicted global An. stephensi climatically suitable areas. Results According to the predictions of this study, some areas where there are no current records of An. stephensi, showed significant areas of climatically suitable for An. stephensi. In addition, the global climatically suitability areas for An. stephensi are expanding with global climate change, with some areas changing from unsuitable to suitable, suggesting a greater risk of invasion of An. stephensi in these areas, with the attendant possibility of a resurgence of malaria, as has been the case in Djibouti. Conclusions This study provides evidence for the possible invasion and expansion of An. stephensi and serves as a reference for the optimization of targeted monitoring and control strategies for this malaria vector in potential invasion risk areas.

show abstract

Biochemical basis of alphamethrin resistance in different life stages ofAnopheles stephensistrains of Bangalore, India

Cited by 5 publications

References 47 publications

Biochemical Effects of <em>Petroselinum crispum</em> (Umbellifereae) Fruit Oil on the Pyrethroid Susceptible and Resistant Strains of <em>Aedes aegypti</em> (Diptera: Culicidae)

Biochemical Effects of <em>Petroselinum crispum</em> (Umbellifereae) Fruit Oil on the Pyrethroid Susceptible and Resistant Strains of <em>Aedes aegypti</em> (Diptera: Culicidae)

Evolution of insecticide resistance and its mechanisms in Anopheles stephensi in the WHO Eastern Mediterranean Region

Possible potential spread of Anopheles stephensi, the Asian malaria vector

Contact Info

Product

Resources

About