Biochemical Association of Hyperprolactinemia with Hypothyroidism in Infertile Women

Prevalence of hyperprolactinemia in infertile cases and its correlation with TSH in a rural set up hospital

“…There was no case with hyperthyroidism. There was a positive correlation between hyperprolactinemia and hypothyroidism as reported by Sharma N (2012), 11 Emokpae MA et al (2011). 24 The ratio of proportions between hypothyroidism and hyperprolactinaemia was 1:7.…”

“…22 Thus it is assumed that as the serum prolactin value in the study was less than 100 ng/ml, therefore the possibility of presence of adenoma was less. Mean serum prolactin in primary and secondary infertility group did not show any significant difference similar to finding of N. Sharma et al (2012). 11 The present study has shown that 65 (32.5%) cases sought medical advice within 5 years of infertility and remaining 135 (67.5%) cases sought medical advice after 5 years (Table 4).…”

“…Mean serum prolactin in primary and secondary infertility group did not show any significant difference similar to finding of N. Sharma et al (2012). 11 The present study has shown that 65 (32.5%) cases sought medical advice within 5 years of infertility and remaining 135 (67.5%) cases sought medical advice after 5 years (Table 4). Similarly analysis of duration of infertility in hyperprolactinemic cases has shown that the majority of 19(82.6%) cases had infertility of less than 10 years (Table 5).…”

“…5 cases out of 23 hyperprolactinemic cases had hypothyroidism (Table 7). 11 There is overall higher incidence of primary infertility in the population. 12 In the present study, analysis of age revealed that the maximum of 53% cases were in the age group of 26 to 30 years with mean age being 27.50±3.76.…”

Hypothyroidism and hyperprolactinemia showed positive correlation in women with primary and secondary infertility

“…12 In a similar study Sharma et al, investigated prolactin and TSH levels in primary and secondary infertile women and determined galactorrhea in 15% of the subjects. 13 In addition, serum prolactin levels were measured as 79.40±56.59 ng/ml in hyperprolactinemic women; however, they reported no statistically significant difference in the levels of prolactin between the women with primary and secondary infertility. The cause of infertility and menstrual irregularities is said to be anovulation resulting from hyperprolactinemia.…”