Biochemical Assessment of Protein-Calorie Malnutrition

McFarlane, H.; Adcock, K. J.; Cooke, A. R.; Ogbeide, M. I.; Adeshina, H.; Taylor, G. Oladunni; Reddy, S.; Gurney, J. M.; Mordie, J.A.

doi:10.1016/s0140-6736(69)91357-9

Cited by 112 publications

(22 citation statements)

References 17 publications

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“…Hemoglobin values averaged about 10g% on admission, although after 1 week of treatment the hemoglobin values of 50% of patients dropped to below 10g%. The plasma protein values for the three main classes of PCM were typical of those reported previously (26)(27)(28). Serum albumin levels were markedly depressed in the kwashiorkor group.…”

Section: Clinical and Laboratory Findingssupporting

confidence: 84%

Clinical aspects of protein deficiency with special reference to protein calorie malnutrition (PCM) in children.

Thanangkul

Damrongsak

Vithayasai

et al. 1980

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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Section: Clinical and Laboratory Findingssupporting

confidence: 84%

Clinical aspects of protein deficiency with special reference to protein calorie malnutrition (PCM) in children.

Thanangkul

Damrongsak

Vithayasai

et al. 1980

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…Increased total body fat has been previously documented in some adults and children with CRF (15,19), and would tend to obscure the effects of depleted body cell mass on body weight, and therefore weight for height index. Serum transferrin has also been used as an index of nutritional status in both PCM (32) and CRF (47), and was closely correlated with weight for height index in Group I of our study (Table 3). Although within the normal range in most cases, mean levels were significantly reduced in Group I children, in whom serum transferrin was correlated significantly with HSDS.…”

Section: Discussionsupporting

confidence: 52%

The Effects of Chronic Renal Failure in Infancy on Growth, Nutritional Status and Body Composition

et al. 1982

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Summaryimportant contributory factor (24) which, compounded by horGrowth, body composition, and nutritional status were assessed monal and metabolic abnormalities, leads to a state of body in 21 children (age range, 0.3-11.9 years) with advanced chronic protein depletion. The similarities between children with CRF renal failure (CRF, glomerular filtration rate <20 ml/min/1.73m2), and those with protein-calorie malnutrition (PCM) have been which had presented in the first year of life. Height standard previously noted (9, 23)' Evidence protein in CRF deviation score was -2 or less in 16 children. Intracellular water includes reduction in alkaline soluble protein on muscle biopsy (ICW), an index of body cell mass, was reduced compared to (17), decreased whole body protein and albumin turnover (4, 16), values predicted for height in 14 children studied under years of decreased plasma and intracellular concentrations of certain esage lGroup I, mean ICW observed:predicted ratio (O/P) 0.67, sential amino acids (7,27), decreased levels of short half-life serum range 0.50-0.931, but was normal in seven prepubertal children proteins (27,47), an increased protein catabolic response to fasting studied between 5-1 1.9 years of age ( G~~~~ 11, mean ICW O/P (221, reduced total body nitrogen (341, and reduced body cell mass 1.01, range 0.88-1.23, P < 0.01 compared to Group I). Both ICW as estimated by measurement of ICW (6,14,15,19) and total O/P and weight for height index increased significantly with age body potassium (TBK) (39, 43). In infancy, when calorie and throughout childhood ( r = 0.79, P < 0.001 and r = 0.62, P < 0.05, protein requirements per kg and rates of growth and nitrogen respectively). In Group I, height standard deviation score corre-accretion are greatest, the of llraemia is likely to be lated significantly with ICW O/P, weight for height index, and particularly severe. Studies confirm that children whose CRF serum transferrin. The most growth retarded children had the dates from life are indeed the most growth retarded (2, 20, most marked reduction in body cell mass, were the most wasted, 33) as a result not of poor growth throughout childhood, but and had the lowest serum transferrin levels. In this group mean rather due to early loss of growth potential (2, 33). Whilst abnorserum transferrin was significantly reduced compared to normal, malities of body composition and metabolism in older children and levels were closely correlated with weight for height index. and adults with CRF have been extensively investigated, no Repeat estimations of ICW, performed in seven Group I children studies on the effects of uraemia in infancy are available. We have after an interval of 0.4-0.8 years, showed an increase towards therefore examined, in a group of infants and children whose predicted in six cases. In Group 11, mean weight for height CRF had presented in the first year of life, the and index was normal (101%, range 90-114%) and significantly greater later effects of their uraemia on growth, nutrition and bod...

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“…The reduction was, however, small compared with that seen in protein-calorie-malnourished children [10,13,23,24], who also show a low ceruloplasmin [11]. This suggests a milder degree of protein deficiency in animals undernourished by the present method.…”

Section: Discussionmentioning

confidence: 66%

“…Rats received injections (i.m.) of corticosterone-l/3,2£-3 H [27] (30 ^Ci/g body wt) and were killed after different intervals (10,20,30, 60, 120 min). Brain, spleen, and thymus were solubilized in Hyamine hydroxide (10% (w/v) in methanol) and radioactivity was determined by liquid scintillation counting.…”

Section: Uptake In Vivo Of ( 3 H)corticosterone Into Different Organsmentioning

confidence: 99%

Uptake of (3H)Corticosterone and the Immune Response in Growth-retarded Rats

et al. 1973

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ExtractMaternal rats were underfed during pregnancy and lactation. At 7 days of age their offspring received one injection of sheep erythrocytes. The immune response (hemolytic plaque-forming cells in spleen and thymus) to this antigen showed a peak at 15 days of age in undernourished rats, 2 days later than in normal animals. However, the size of this response at its peak was, in the undernourished group, at least appropriate for body weight. Growth retardation during the fetal and suckling periods resulted also in an increased rate of uptake of 3 H-corticosterone into spleen and thymus in vivo. Speculation

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Biochemical Assessment of Protein-Calorie Malnutrition

Cited by 112 publications

References 17 publications

Clinical aspects of protein deficiency with special reference to protein calorie malnutrition (PCM) in children.

Clinical aspects of protein deficiency with special reference to protein calorie malnutrition (PCM) in children.

The Effects of Chronic Renal Failure in Infancy on Growth, Nutritional Status and Body Composition

Uptake of (3H)Corticosterone and the Immune Response in Growth-retarded Rats

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