Biochemical Aspects of Cobalt Deficiency in Sheep with Special Reference to Vitamin Status and a Possible Involvement in the Aetiology of Cerebrocortical Necrosis

Macpherson, Allan; Moon, F. E.; Voss, R. C.

doi:10.1016/s0007-1935(17)34689-4

Cited by 43 publications

(12 citation statements)

References 16 publications

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“…This means that these supplemented lambs were B12 deficient during part of the experimental period. Year-to-year differences in weight gain (Figure 2) and in the severeness of clinical signs in cobalt/vitamin B12-deficient lambs have also been reported by others (9,25). The clinical signs of the non-supplemented lambs were identical to those described elsewhere (5,11,15,19,23,24,28).…”

Section: Discussionsupporting

confidence: 78%

“…The non-supplemented lambs always had serum vitamin B12 concentrations around or below 200 pmo1/1 at the start of the experimental periods and these values dropped to below 100 pmo1/1 during the experiments. Suttle (20) suggested that a serum vitamin B12 concentration of 188 pmo1/1 is probably the threshold between marginal and functional deficiency, while others indicate the margin to be between 150 and 300 pmo1/1 (2,6,7,9,16,21,22). This indicates that the non-supplemented lambs were B12 deficient shortly after the start of the experiment.…”

Section: Discussionmentioning

confidence: 99%

“…Fortunately, the results of field studies that have been carried out on a limited scale indicate that PRV can be eradicated in such regions by area-wide vaccination (12). On the basis of these results, several countries of the European Union have started an area-wide vaccination campaign (9).…”

Section: Introductionmentioning

confidence: 99%

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Effect of cobalt supplementation on serum vitamin B₁₂levels, weight gain and survival rate in lambs grazing cobalt‐deficient pastures

Vellema¹,

Moll²,

Barkema³

et al. 1997

Veterinary Quarterly

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SUMMARYThe effect of cobalt supplementation on serum vitamin B129 growth rate and survival rate was measured in controlled field experiments with Texel twin lambs of the same sex, grazing cobalt-deficient pastures. The non-supplemented lambs had lower serum vitamin B12 concentrations than their supplemented brothers or sisters. During the experiments more lambs died in the non-supplemented than in the supplemented group. At the end of the experiments supplemented lambs weighed (mean live weight) 7.2, 9.5, and 11.0 kg more than nonsupplemented lambs in 1991, 1992, and 1993, respec-tively.Sex-related differences in weight gain and survival rate were observed.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of cobalt supplementation on serum vitamin B₁₂levels, weight gain and survival rate in lambs grazing cobalt‐deficient pastures

Vellema¹,

Moll²,

Barkema³

et al. 1997

Veterinary Quarterly

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“…Known causes of PEM in ruminants are thiaminase, 17 lead, 18 hydrogen sulfide (manure gas), 19 sodium ion (salt) 20 and sulfur 6,7 poisonings, and cobalt deficiency 21 . Known thiaminase sources available to grazing ruminants on the Darling Downs in descending order of potency 22 are Marsilea spp.…”

Section: Discussionmentioning

confidence: 99%

Sulfur‐associated polioencephalomalacia in cattle grazing plants in the Family Brassicaceae

McKenzie¹,

Carmichael

Schibrowski

et al. 2009

Aust Veterinary J

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Polioencephalomalacia was diagnosed histologically in cattle from two herds on the Darling Downs, Queensland, during July-August 2007. In the first incident, 8 of 20 18-month-old Aberdeen Angus steers died while grazing pastures comprising 60%Sisymbrium irio (London rocket) and 40%Capsella bursapastoris (shepherd's purse). In the second incident, 2 of 150 mixed-breed adult cattle died, and another was successfully treated with thiamine, while grazing a pasture comprising almost 100%Raphanus raphanistrum (wild radish). Affected cattle were either found dead or comatose or were seen apparently blind and head-pressing in some cases. For both incidents, plant and water assays were used to calculate the total dietary sulfur content in dry matter as 0.62% and 1.01% respectively, both exceeding the recommended 0.5% for cattle eating more than 40% forage. Blood and tissue assays for lead were negative in both cases. No access to thiaminase, concentrated sodium ion or extrinsic hydrogen sulfide sources were identified in either incident. Below-median late summer and autumn rainfall followed by above-median unseasonal winter rainfall promoted weed growth at the expense of wholesome pasture species before these incidents.

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“…Johnson et al (2004) reported increased ALP levels in Co-deprived Omani goats. The elevation of ALP has been reported as a sign of chronic liver disease, hepatic fibrosis, cholangitis, obstruction, cholestasis and most commonly with hepatic lipidosis (MacPherson et al, 1976;Kramer and Hoffmann, 1997;Johnson et al, 2004). Therefore, goat kids in the present study received adequate amounts of Co from the basal diet to prevent liver damages.…”

Section: Cobalt Supplementation In Goat Kidsmentioning

confidence: 91%

A comparison between different concentrations and sources of cobalt in goat kid nutrition

Dezfoulian

Aliarabi

2017

Animal

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There have been extensive studies in sheep and cattle considering cobalt (Co) supplementation and its effects on vitamin B12 concentrations in the body. However, there are limited studies on goats. The aim of this study was to compare two different sources of Co (sulfate v. glucoheptonate) at two different concentrations (0.25 and 0.5 mg/kg dry matter) in goat kid nutrition, and to evaluate the effects of these supplements on performance, serum vitamin B12, blood biochemistry and rumen volatile fatty acids. For this purpose, 30 weaned male goat kids were randomly allotted to five treatments. Serum vitamin B12 increased during the trial in the Co-supplemented groups. Co supplementation increased serum glucose concentrations. On day 35, Co-supplemented groups had greater glucose concentrations compared with control. Propionic+iso-butyric acid concentrations increased only in the 0.5 mg Co glucoheptonate treatment (P<0.05). Our results suggest that, despite the two sources of Co proving mostly similar, the main advantage of Co glucoheptonate compared with Co sulfate was in the ruminal synthesis of vitamin B12. However, although providing Co at National Research Council recommendation levels maintained vitamin B12 above or at normal concentrations, Co supplementation of the Co sufficient basal diet increased vitamin B12 and glucose concentrations.

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Biochemical Aspects of Cobalt Deficiency in Sheep with Special Reference to Vitamin Status and a Possible Involvement in the Aetiology of Cerebrocortical Necrosis

Cited by 43 publications

References 16 publications

Effect of cobalt supplementation on serum vitamin B₁₂levels, weight gain and survival rate in lambs grazing cobalt‐deficient pastures

Effect of cobalt supplementation on serum vitamin B₁₂levels, weight gain and survival rate in lambs grazing cobalt‐deficient pastures

Sulfur‐associated polioencephalomalacia in cattle grazing plants in the Family Brassicaceae

A comparison between different concentrations and sources of cobalt in goat kid nutrition

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Biochemical Aspects of Cobalt Deficiency in Sheep with Special Reference to Vitamin Status and a Possible Involvement in the Aetiology of Cerebrocortical Necrosis

Cited by 43 publications

References 16 publications

Effect of cobalt supplementation on serum vitamin B12levels, weight gain and survival rate in lambs grazing cobalt‐deficient pastures

Effect of cobalt supplementation on serum vitamin B12levels, weight gain and survival rate in lambs grazing cobalt‐deficient pastures

Sulfur‐associated polioencephalomalacia in cattle grazing plants in the Family Brassicaceae

A comparison between different concentrations and sources of cobalt in goat kid nutrition

Contact Info

Product

Resources

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Effect of cobalt supplementation on serum vitamin B₁₂levels, weight gain and survival rate in lambs grazing cobalt‐deficient pastures

Effect of cobalt supplementation on serum vitamin B₁₂levels, weight gain and survival rate in lambs grazing cobalt‐deficient pastures