Biochemical Aspects of Cholinergic Transmission in Insect Central Nervous System

The pharmacological properties of some crustacean neuronal acetylcholine, gamma‐aminobutyric acid, and L‐glutamate responses.

“…In several of these studies it was shown that both nicotinic and muscarinic agonists were active (Kerkut et al 1969;Shankland et al 1971) and it is possible that careful pharmacological studies will show the presence ACh, GABA, AND L-GLU ON CRAB NEURONES of pharmacologically separable nicotinic and muscarinic physiological ACh responses in insect ganglia. Should this be so, it would aid in the interpretation of the large and interesting literature of binding studies on insect preparations using various cholinergic ligands (Donnellan & Harris, 1977;Sanes, Prescott & Hildebrand, 1977;Schmidt-Nielson, Gepner, Teng & Hall, 1977). Crustacean ACh receptors have been studied much less extensively than insect receptors, but those receptors briefly described on other crustacean neurones (McLennan & York, 1966;Barker, Herbert, Hildebrand & Kravitz, 1972; Wallace, Talamo, Evans & Kravitz, 1974) are similar to those described here.…”