Biochemical and physiological parameters on the healthy skin surface of persons with candidal intertrigo and of persons with Tinea Cruris

Abstract

Biochemical and physiological tests were carried out on the skin surface of 20 patients with candidal intertrigo and 27 patients with tinea cruris. In all patients the test areas were free of efflorescences. The same tests were performed in 39 and 27 resectively healthy test persons of the same age and sex. The following striking findings came to light: 1. There was a significant decrease in the percentage amount of squalene in the skin surface lipids of the moniliasis group as compared with the control group. 2. There was a significant decrease in the reducing substances in the so called water solubles obtained with the phenol sulfuric acid method in the moniliasis group. The same results were obtained when only those moniliasis patients who were definitely not suffering from diabetes mellitus were taken into account. This is presumably a question of a reduction in the bound carbohydrates. 3. There were significantly more amino acids extractable from the skin surface of the tinea cruris patients than of the control persons. These results point to important predisposing factors for the susceptibility to candidal intertrigo and tinea cruris respectively.

Biochemical and Physiological Parameters on the Healthy Skin Surface of Patients with Common Warts

“…We had earlier obtained a similar result in patients with candidal inter trigo [3], In previous experiments we were able to show that the release of fatty acids from the triglycerides through bacterial lipases found in the excretory passages of the sebaceous glands is dependent on the amount of the squalene fraction in the skin surface lipids [4], This corresponds with the tendentiously recognizable, although nonsignificant increase in the free fatty acids at the expense of the triglycerides in our present experiments. It is noteworthy that in our earlier experiments an increase in the squalene fraction of the skin surface lipids was determined in persons suffering from contact allergy [11], It should be discussed whether a predisposition for common warts excludes a disposition for contact allergy.…”