Biochemical and Molecular Instabilities in Obesity and its Risk for Cardiovascular Disease

Abstract

Obesity, characterized by an increase in body weight that results in excessive fat accumulation, represents a social problem worldwide and has been recognized as a major factor for the pathogenesis of several diseases. Obesity is one of the most important risk factor for CVD. The goal of the present study was to evaluate the biochemical and molecular instabilities in obesity and its risk for cardiovascular disease. Thirty one obese subjects were selected as study subjects and twenty five healthy subjects without any chronic illness were selected as control for the present study. The role of oxidative stress measured by the level of oxidative stress marker, Malondialdehyde (MDA) and the DNA damages were quantified by Cytokinesis-Block Micronuclei (CBMN) assay. Detailed demographic, clinical and lifestyle characteristics were compared with subjects. The MDA value and the micronuclei frequency was significantly elevated in study subjects as compared with that of control subjects. Obese individuals experience substantially elevated morbidity and mortality from all forms of CVD.