Biochemical and Molecular Genetics of Cystic Fibrosis

Tsui, Lap‐Chee; Buchwald, Manuel

doi:10.1007/978-1-4684-5958-6_4

Cited by 85 publications

(27 citation statements)

References 412 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Cystic fibrosis (CF), 1 the most common fatal genetic disease is characterized by defective chloride transport across epithelia of the airways, exocrine ducts, and intestine as well as viscous epithelial mucous secretions (1)(2)(3). The mutated gene that causes CF encodes the cystic fibrosis transmembrane conductance regulator (CFTR) (3).…”

Section: Chloride Channels Play An Important Role In the Physiology Amentioning

confidence: 99%

“…and fail to traffic to the plasma membrane, have a reduced conductance, or are incorrectly regulated by physiological stimuli (4, 9 -11). This disrupts the normal transport of salt, water, and proteins across epithelial tissues, which leads to the production of thickened secretory product and to progressive obstruction of secretory ducts leading to organ dysfunction (1,2).…”

Section: Chloride Channels Play An Important Role In the Physiology Amentioning

confidence: 99%

See 1 more Smart Citation

Development of Substituted Benzo[c]quinolizinium Compounds as Novel Activators of the Cystic Fibrosis Chloride Channel

Becq

Mettey

Gray³

et al. 1999

Journal of Biological Chemistry

104

100

View full text Add to dashboard Cite

Section: Chloride Channels Play An Important Role In the Physiology Amentioning

confidence: 99%

Section: Chloride Channels Play An Important Role In the Physiology Amentioning

confidence: 99%

Development of Substituted Benzo[c]quinolizinium Compounds as Novel Activators of the Cystic Fibrosis Chloride Channel

Becq

Mettey

Gray³

et al. 1999

Journal of Biological Chemistry

104

100

View full text Add to dashboard Cite

“…Hispanics, Blacks, and Asians are also affected, but in smaller numbers [4]. CF affects the liver, pancreas and intestinal tract but the major causes of morbidity and mortality are the lung disease [5].…”

Section: Introductionmentioning

confidence: 99%

Targeting neutrophil elastase in cystic fibrosis

Kelly

Greene

McElvaney

2008

Expert Opinion on Therapeutic Targets

View full text Add to dashboard Cite

show abstract

“…It is a complicated multisystem disease that involves the respiratory tract, the male genital tracts, the hepatobiliary system, the endocrine system and the epithelium cells of the perspiratory glands. Additionally, the gene of the disease and the protein that is the product of the disease (Cystic Fibrosis Transmembrane Regulator Protein) and its functions are clearly defined [13][14][15]. Thus, it offers a good model in helping the students acquire both clinical and molecular knowledge.…”

Section: Discussionmentioning

confidence: 99%

Cystic Fibrosis in Medical Education

Boz¹

2012

J Community Med Health Edu

View full text Add to dashboard Cite

Aim: The aim of the present study was to introduce the Problem Based Learning (PBL) module on cystic fibrosis applied in Akdeniz University Medical School, to present the feedbacks of the tutors and the students about the module and to evaluate the student success achieved in the module. Method:The study group consists of all first semester students (n=208) and the tutors in charge of this PBL module (n=21).In order to acquire the feedbacks of the students and tutors on the scenario and the implementation of the PBL module, a questionnaire consisting of six questions was administered to the study group at the final session of the PBL course. Additionally, another questionnaire was administered to the students to determine the opinions of the students about whether the module positively contributed to their present knowledge level.Results: 94.7% of the students (n=197) and 85.7% of the tutors (n=18) responded to the feedback form aimed at receiving the feedbacks on the scenario and implementation of the PBL module. The responses given to this questionnaire showed that the tutors and the students gave identical scores to all the items and there was not a statistically significant difference between the two groups. The average PBL exam score of the students was 112.3 (maximum score=150) and their average course committee examination score was 539.7 (maximum score=850). Conclusion:As a result, it was determined that the feedbacks of the students and tutors about the PBL module on cystic fibrosis, a fatal health problem that has received attention in the recent years, were positive and high student success was achieved with the module. IntroductionSince 1970s, there has been a tendency to revise educational programs, implement up-to-date and novel methods and focus on student-oriented education in order to educate better qualified doctors [1,2]. In our country, the milestones of this change process are the student-oriented education, which began to be implemented in 1997, and the National Seed Program, which was published in 2001 [3,4]. One important purpose of these changes is to furnish the students with the adequate knowledge and skills that they need in approaching frequently seen diseases and to bring about a change in their attitude. Studentoriented instructional methods contribute greatly to the achievement of this purpose [5]. The most commonly used student-oriented educational method is Problem-Based Learning (PBL). This educational model helps the student to develop the skills of using his/her knowledge in problem-solving, analyzing and synthesizing information, determining what he/she needs to learn and finding out how to access the knowledge he/she lacks. In the end, the student becomes able to synthesize and analyze information, acquires the ability of lifelong learning [6][7][8] and learns where and how to use the knowledge he/she gained [9,10]. These benefits of PBL make it increasingly more popular in the medical schools throughout the world.The most important instrument of PBL in achieving ...

show abstract

Biochemical and Molecular Genetics of Cystic Fibrosis

Cited by 85 publications

References 412 publications

Development of Substituted Benzo[c]quinolizinium Compounds as Novel Activators of the Cystic Fibrosis Chloride Channel

Development of Substituted Benzo[c]quinolizinium Compounds as Novel Activators of the Cystic Fibrosis Chloride Channel

Targeting neutrophil elastase in cystic fibrosis

Cystic Fibrosis in Medical Education

Contact Info

Product

Resources

About