Biochemical and locomotor responses of Carcinus maenas exposed to the serotonin reuptake inhibitor fluoxetine

Mesquita, Sofia Raquel; Guilhermino, Lúcia; Guimarães, Laura

doi:10.1016/j.chemosphere.2011.06.067

Cited by 72 publications

(44 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Fluoxetine concentrations ≥120 μg/L caused a stimulation of locomotor behavior in the crab Carcinus maenas (Mesquita et al., 2011). We found similar increases in mobile behaviors in H. oregonensis exposed to only 30 ng/L of fluoxetine.…”

Section: Discussionmentioning

confidence: 99%

“…Perhaps fluoxetine, through modulation of serotonin levels, stimulates crab activity levels and drives aggressive behaviors. Fluoxetine's effect on serotonin levels appears to increase boldness and potentially other risk behaviors as studies on other species have suggested (Dzieweczynski & Hebert, 2012; Fong & Ford, 2014; Mesquita et al., 2011; Pedetta et al., 2010; Tierney & Mangiamele, 2001). …”

Section: Discussionmentioning

confidence: 99%

“…McPhee and Wilkens (1989) found that Carcinus maenas crabs injected with serotonin increased their activity levels during the day, whereas normally they are photonegative. In the same crab species, 120 μg/L of fluoxetine significantly altered locomotor behaviors (Mesquita, Guilhermino, & Guimaraes, 2011). Several other studies have demonstrated that fluoxetine leads to adverse physiological and behavioral outcomes in aquatic organisms that could alter their functional roles within the community (Bossus, Guler, Short, Morrison, & Ford, 2014; Chen, Zha, Yuan, & Wang, 2015; Dzieweczynski & Hebert, 2012; Munari, Marin, & Matozzo, 2014; Peters & Granek, 2016; Schultz et al., 2011).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Prozac in the water: Chronic fluoxetine exposure and predation risk interact to shape behaviors in an estuarine crab

Peters

Granek

Rivera

et al. 2017

Ecology and Evolution

View full text Add to dashboard Cite

Predators exert considerable top‐down pressure on ecosystems by directly consuming prey or indirectly influencing their foraging behaviors and habitat use. Prey is, therefore, forced to balance predation risk with resource reward. A growing list of anthropogenic stressors such as rising temperatures and ocean acidification has been shown to influence prey risk behaviors and subsequently alter important ecosystem processes. Yet, limited attention has been paid to the effects of chronic pharmaceutical exposure on risk behavior or as an ecological stressor, despite widespread detection and persistence of these contaminants in aquatic environments. In the laboratory, we simulated estuarine conditions of the shore crab, Hemigrapsus oregonensis, and investigated whether chronic exposure (60 days) to field‐detected concentrations (0, 3, and 30 ng/L) of the antidepressant fluoxetine affected diurnal and nocturnal risk behaviors in the presence of a predator, Cancer productus. We found that exposure to fluoxetine influenced both diurnal and nocturnal prey risk behaviors by increasing foraging and locomotor activity in the presence of predators, particularly during the day when these crabs normally stay hidden. Crabs exposed to fluoxetine were also more aggressive, with a higher frequency of agonistic interactions and increased mortality due to conflicts with conspecifics. These results suggest that exposure to field‐detected concentrations of fluoxetine may alter the trade‐off between resource acquisition and predation risk among crabs in estuaries. This fills an important data gap, highlighting how intra‐ and interspecific behaviors are altered by exposure to field concentrations of pharmaceuticals; such data more explicitly identify potential ecological impacts of emerging contaminants on aquatic ecosystems and can aid water quality management.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prozac in the water: Chronic fluoxetine exposure and predation risk interact to shape behaviors in an estuarine crab

Peters

Granek

Rivera

et al. 2017

Ecology and Evolution

View full text Add to dashboard Cite

show abstract

“…[23] On the other hand, the locomotion of the epibenthic crab Carcinus maenas is significantly increased for concentrations of fluoxetine equal or above 120 μgL −1 . [24] In the present work, the toxicity of five medicines (three generic and two brand labels) used in the treatment of depression, which are available in the Portuguese market, was tested on the alga Chlorella vulgaris. All the medicines have the same active substance -fluoxetine.…”

Section: Introductionmentioning

confidence: 99%

Impact of excipients in the chronic toxicity of fluoxetine on the algaChlorella vulgaris

Silva

Santos

Delerue–Matos

et al. 2014

Environmental Technology

View full text Add to dashboard Cite

Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) widely used in the treatment of major depression. It has been detected in surface and wastewaters, being able to negatively affect aquatic organisms. Most of the ecotoxicity studies focused only in pharmaceuticals, though excipients can also pose a risk to non-target organisms. In this work the ecotoxicity of five medicines (three generic formulations and two brand labels) containing the same active substance (fluoxetine hydrochloride) was tested on the alga Chlorella vulgaris, in order to evaluate if excipients can influence their ecotoxicity. Effective con-centrations that cause 50% of inhibition (EC 50 ) ranging from 0.25 to 15 mg L −1 were obtained in the growth inhibition test performed for the different medicines. The corresponding values for fluoxetine concentration are 10 times lower. Higher EC 50 values had been published for the same alga considering only the toxicity of fluoxetine. Therefore, this increase in toxicity may be attributed to the presence of excipients. Thus more studies on ecotoxicological effects of excipients are required in order to assess the environmental risk they may pose to aquatic organisms.

show abstract

“…1,2 Consequently, it has been used to assess the impact of metals, 3 pesticides, 4 xenostrogens 5 and drugs. 6 Naturally, shore crabs display a high tolerance to fluctuations of abiotic factors in their environment, which may entail hypoxia, salinity changes or temperature stress (heat-shock and/or cold shock, respectively). They also resist considerably to anthropogenic pollution of the aquatic environment deriving from urban, industrial, agricultural and marine activities.…”

Section: Introductionmentioning

confidence: 99%

A convenient device for xenobiotic dosing and haemolymph sampling in Carcinus maenas (Portunidae, Decapoda)

et al. 2014

View full text Add to dashboard Cite

show abstract

Biochemical and locomotor responses of Carcinus maenas exposed to the serotonin reuptake inhibitor fluoxetine

Cited by 72 publications

References 65 publications

Prozac in the water: Chronic fluoxetine exposure and predation risk interact to shape behaviors in an estuarine crab

Prozac in the water: Chronic fluoxetine exposure and predation risk interact to shape behaviors in an estuarine crab

Impact of excipients in the chronic toxicity of fluoxetine on the algaChlorella vulgaris

A convenient device for xenobiotic dosing and haemolymph sampling in Carcinus maenas (Portunidae, Decapoda)

Contact Info

Product

Resources

About