Abstract:Agmatine plays neurotransmitter/neuromodulatory actions in the brain. It result from decarboxylation of arginine by arginine decarboxylase and it is hydrolysed by agmatinase. Recently, we have cloned an unusual rat brain protein with agmatinase activity, although their deduced sequences greatly differ from all known agmatinases. However, in spite of only 12% identity with E. coli agmatinase, the rat brain protein is recognized by a polyclonal antibody raised against the bacterial enzyme. Like E. coli agmatinas… Show more
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