Biochemical and hormonal abnormalities in adult female acne

Meena, Amit Kumar; Mendiratta, Vibhu; Goyal, Ruchi; Bisherwal, Kavita; Yadav, Vidya; Prasadh, Vivin

doi:10.1111/jocd.15588

Cited by 2 publications

(2 citation statements)

References 28 publications

(124 reference statements)

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“…The study by Meena et al revealed an elevated prolactin serum level in 2 out of 60 acne patients (3.3%). Moreover, 6.7% of patients presented a raised total testosterone level [ 32 ]. In the study by Dhaher et al, in up to 32% of patients with acne, the measured prolactin serum level was above the normal range [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, there was no correlation between the hormone level and acne severity [ 30 ]. In the study by Meena et al, elevated LH and FSH serum levels were found in 3.3% and 18.3% of acne patients, respectively [ 32 ]. The study by Khunger et al revealed an elevated LH serum level in 2 out of 280 patients and a decreased FSH serum level in 1 patient.…”

Section: Discussionmentioning

confidence: 99%

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Selected hormone levels and lipid abnormalities in patients with acne vulgaris

Szybiak,

Jarzemska,

Kowalczyk

et al. 2023

pdia

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Introduction Acne vulgaris is one of the most common dermatological diseases. Hormonal imbalance affects the skin condition and results in the formation of acne vulgaris lesions. Aim To evaluate serum levels of testosterone, prolactin, luteinizing hormone (LH), follicle-stimulating hormone (FSH), triglycerides (TG), and high-density lipoprotein (HDL) in patients with acne vulgaris and compare them to healthy population. Material and methods Forty-one patients with acne vulgaris and 47 age- and body mass index (BMI)-matched controls were enrolled in the study. Results The mean ± SD testosterone serum level in the study group was 0.45 ±1.03 ng/ml in females and 4.24 ±0.68 in males and in the control group 0.73 ±2.03 ng/ml and 5.3 ±1.3 ng/ml in females and males, respectively. The prolactin serum level was 16.73 ±8.02 ng/ml in the study group and in the control group 13.74 ±8.71 ng/ml ( p = 0.011). The FSH serum level was 12.17 ±16.93 mIU/ml and 6.2 ±7.3 mIU/ml in the study and control groups, respectively ( p = 0.0001), whereas LH serum levels were 18.44 ±19.71 mIU/ml and 11.26 ±8 mIU/ml, respectively ( p = 0.2659). The HDL serum level was 65.63 ±15.67 mg/dl in the study group and 61.53 ±15.89 mg/dl in the control group ( p = 0.219), and TG levels were 175.29 ±82.15 mg/dl and 87.32 ±30.64 mg/dl, respectively ( p < 0.00001). Conclusions Our study demonstrates, that hormonal and lipid imbalance could be linked to acne vulgaris formation. Evaluation of hormonal and lipid abnormalities could help in treatment decisions and could affect the occurrence of complications and the course of acne.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Selected hormone levels and lipid abnormalities in patients with acne vulgaris

Szybiak,

Jarzemska,

Kowalczyk

et al. 2023

pdia

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Prolactin: A Mammalian Stress Hormone and Its Role in Cutaneous Pathophysiology

Langan

2024

IJMS

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The hormone prolactin (PRL) is best recognised for its indispensable role in mammalian biology, specifically the regulation of lactation. Bearing in mind that the mammary gland is a modified sweat gland, it is perhaps unsurprising to discover that PRL also plays a significant role in cutaneous biology and is implicated in the pathogenesis of a range of skin diseases, often those reportedly triggered and/or exacerbated by psychological stress. Given that PRL has been implicated in over 300 biological processes, spanning reproduction and hair growth and thermo- to immunoregulation, a comprehensive understanding of the relationship between PRL and the skin remains frustratingly elusive. In an historical curiosity, the first hint that PRL could affect skin biology came from the observation of seborrhoea in patients with post-encephalitic Parkinsonism as a result of another global pandemic, encephalitis lethargica, at the beginning of the last century. As PRL is now being postulated as a potential immunomodulator for COVID-19 infection, it is perhaps timeous to re-examine this pluripotent hormone with cytokine-like properties in the cutaneous context, drawing together our understanding of the role of PRL in skin disease to illustrate how targeting PRL-mediated signalling may represent a novel strategy to treat a range of skin diseases and hair disorders.

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Biochemical and hormonal abnormalities in adult female acne

Cited by 2 publications

References 28 publications

Selected hormone levels and lipid abnormalities in patients with acne vulgaris

Selected hormone levels and lipid abnormalities in patients with acne vulgaris

Prolactin: A Mammalian Stress Hormone and Its Role in Cutaneous Pathophysiology

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