Abstract. Background/Aim: Numerous evidence has shown that PEITC and BITC inhibit cancer cell migration and invasion. In this study, we investigated the anti-metastatic mechanisms of PEITC and BITC in human melanomaSkin cancer is one of the most common malignant neoplasms in the white population. Melanoma is much more common in whites than in other ethnic groups (1). In USA, the incidence of melanoma is the fifth and seventh most common cancer among men and women, respectively (2). Worldwide, the incidence rate of melanoma skin cancer is increasing (3). At ages over the age of 75 years old, the incidence rate is almost three times higher in males than that in females (4, 5). In the past years, metastatic melanomas have been increased and led to a high rate of death 6223