Biochanin A mitigates ulcerative colitis and intestinal inflammation in mice by inhibiting MAPK/NF‐kB (p65) axis
Uttam Kulhari,
Ashitha Rajanan,
Anju Ambujakshan
et al.
Abstract:Ulcerative colitis (UC) is a chronic problem of the intestine and relapsing in nature. Biochanin A is a nature‐derived isoflavonoid and has numerous bioactivities. However, its role against UC and intestinal inflammation remains obscure. We aimed to comprehensively explore the pharmacological effect of biochanin A in alleviating colitis and to evaluate the potential mechanisms. Initially, we explored the anti‐inflammatory action of biochanin A (15, 30, and 60 μM) by employing lipopolysaccharide (LPS)‐activated… Show more
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