Biochanin A Inhibits Breast Cancer Tumor Growth in A Murine Xenograft Model

Moon, Young Jin; Shin, Beom Soo; An, Guohua; Morris, Marilyn E.

doi:10.1007/s11095-008-9583-6

Cited by 65 publications

(45 citation statements)

References 35 publications

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“…They have also been suggested as novel candidate drugs for AD [29]. As one of the phytoestrogen compounds, biochanin A, has been shown to have an important effect in cancer protection [21,22]. However, there is still much to learn about this phytoestrogen and its beneficial effects on human health.…”

Section: Discussionmentioning

confidence: 99%

“…Its chemical structure resembles that of endogenous estrogen, which is able to displays agonistic and antagonistic interactions with the estrogen receptor. Over the past few years, biochanin A has been applied in research on cancer prophylaxis and neuroprotection studies [20][21][22][23]. Despite the many considerable efforts to study the beneficial effects of biochanin A, there remains a significant lack of understanding of the effects of this compound on the central nervous system.…”

Section: Introductionmentioning

confidence: 99%

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Neuroprotective Effects of Biochanin A against β-Amyloid-Induced Neurotoxicity in PC12 Cells via a Mitochondrial-Dependent Apoptosis Pathway

Tan

Kim

2016

Molecules

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Abstract:Alzheimer's disease is considered one of the major neurodegenerative diseases and is characterized by the production of β-amyloid (Aβ) proteins and progressive loss of neurons. Biochanin A, a phytoestrogen compound found mainly in Trifolium pratense, was used in the present study as a potential alternative to estrogen replacement therapy via the investigation of its neuroprotective effects against Aβ 25-35 -induced toxicity, as well as of its potential mechanisms of action in PC12 cells. Exposure of these cells to the Aβ 25-35 protein significantly increased cell viability loss and apoptosis. However, the effects induced by Aβ 25-35 were markedly reversed in the present of biochanin A. Pretreatment with biochanin A attenuated the cytotoxic effect of the Aβ 25-35 protein by decreasing viability loss, LDH release, and caspase activity in cells. Moreover, we found that expression of cytochrome c and Puma were reduced, alongside with the restoration of Bcl-2/Bax and Bcl-xL/Bax ratio in the presence of biochanin A, which led to a decrease in the apoptotic rate. These data demonstrate that mitochondria are involved in the protective effect of biochanin A against Aβ [25][26][27][28][29][30][31][32][33][34][35] and that this drug attenuated Aβ 25-35 -induced PC12 cell injury and apoptosis by preventing mitochondrial dysfunction. Thus, biochanin A might raise a possibility as a potential therapeutic agent for Alzheimer's disease and other related neurodegenerative diseases.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Neuroprotective Effects of Biochanin A against β-Amyloid-Induced Neurotoxicity in PC12 Cells via a Mitochondrial-Dependent Apoptosis Pathway

Tan

Kim

2016

Molecules

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“…Secondly, BCA has various other biological activities, such as anti proliferative, anti inflammatory -- (Kole et al, 2011), protection of dopaminergic neurons (Chen et al, 2007), stimulation of osteoblastic differentiation, (Lee and Choi, 2005) and inhibition of melanogenesis (Lin et al, 2011). Especially to deserve to be mentioned, data from the animals and the in vitro studies provided that Biochanin A, which are possible through the path of inhabiting the enzyme activity and inducting apoptosis, can reverse, inhabit, or prevent cancers or tumor development, such as prostate cancer (Szliszka et al, 2013), breast cancer (Moon et al, 2008), lung tumor (Lee et al, 1991) and liver cancer (Mansoor et al, 2011).…”

Section: Pharmacological Benefits Of Biochanin Amentioning

confidence: 99%

Biological Activity of Biochanin A: A Review

Sundaresan¹,

Radhiga²,

Deivasigamani³

2018

Asian J Pharm Pharmacol

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Biochanin A (BCA) is a naturally occurring dietary isoflavone found in red clover, and present in several herbal dietary complements. During metabolism, BCA is converted into its conjugates genistein. Recently, the therapeutic examination on BCA is on the ascent many to various putative advantageous properties it might have to treat different human diseases. Particularly BCA has cardiovascular defense, anticancer activity, antioxidant property, antiinflammatory, and anticarcinogenic effects. Most useful health impacts connected to BCA is accepted to be interceded by the estrogenic and antioxidative properties of these compounds. This review examines the literature associated with the most significant biological properties of BCA.

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“…BCA is proposed to reverse, inhibit, or prevent several types of tumors possibly through the inhibition of several enzymatic activities as well as the induction of apoptosis (2,4,5). It has been shown to synergistically enhance the anti-proliferative and apoptotic effects of sorafenib (first line of treatment) in hepatocellular carcinoma cells (6).…”

Section: Introductionmentioning

confidence: 99%

Effect of Biochanin A versus 17β estradiol in rat submandibular salivary gland

2017

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Abstract:The epigenetic nature of development mandates the observation of the effect of any exogenous substance, especially those with estrogenic activities, during critical phases of development. The submandibular gland (SMG) presents as a great model due to extensive postnatal development, and is known to be regulated and affected by hormones as well as growth factors. Herein, we observed postnatal development following low doses of Biochanin A (BCA) and 17β estradiol (E2) in rats. The pups were randomly divided into four groups: control, BCA, E2, and dimethyl sulfoxide (DMSO), and euthanized at the 6th, 15th, 30th, and 60th postnatal days (PND). SMG morphogenesis was assessed. The nuclear expression of estrogen receptor beta (ERβ) was evaluated immunohistochemically; ERβ expression was up-regulated by BCA and down-regulated by E2. Similarly, caspase three gene expression, assessed by real time polymerase chain reaction was increased in the BCA group but decreased in the E2 group. A significant decrease in epidermal growth factor gene expression was noted at PND 30. The results presented by this study provide evidence that the effect of a postnatal exposure of the SMG to Biochanin A during development could be linked to sex hormone-dependent disorders.

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Biochanin A Inhibits Breast Cancer Tumor Growth in A Murine Xenograft Model

Abstract: Our findings indicate that BCA inhibits tumor growth in a xenograft animal model; BCA may represent a breast cancer preventive agent, either administered alone or in combination with other flavonoids.

Cited by 65 publications

References 35 publications

Neuroprotective Effects of Biochanin A against β-Amyloid-Induced Neurotoxicity in PC12 Cells via a Mitochondrial-Dependent Apoptosis Pathway

Neuroprotective Effects of Biochanin A against β-Amyloid-Induced Neurotoxicity in PC12 Cells via a Mitochondrial-Dependent Apoptosis Pathway

Biological Activity of Biochanin A: A Review

Effect of Biochanin A versus 17β estradiol in rat submandibular salivary gland

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