Biocatalytic membrane reactors (BMR)

Vladisavljević, Goran T.

doi:10.1515/psr-2015-0015

Cited by 6 publications

(3 citation statements)

References 144 publications

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“…According to the design of enzymatic reactors using membrane technologies, several configurations are used: (i) a continuously stirred tank reactor (CSTR) combined with a membrane module for product removal and a loop for recirculation of the enzyme; (ii) the membrane is submerged into the reaction tank and, in this case, the separation occurs inside the bioreactor using either hollow or flat-sheet membranes, and additional control is required for preventing cake formation and fouling; and (iii) using a module membrane with a segregation of the enzyme system within a hollow fiber membrane module, operated with feeding into the membrane lumen, and the biocatalyst is placed in the extra-capillary space [93].…”

Section: Membrane Technologiesmentioning

confidence: 99%

Removal of Emerging Contaminants by Degradation during Filtration: A Review of Experimental Procedures and Modeling

Undabeytia,

Jiménez-Barrera,

Nir

2023

Water

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Here, we review the efficient removal of organic micropollutants from water by degradation during filtration using specialized bacteria and enzymes. In both approaches, the filter provides essential binding sites where efficient degradation can occur. A model is presented that enables the simulation and prediction of the kinetics of filtration for a given pollutant concentration, flow rate, and filter dimensions and can facilitate the design of experiments and capacity estimates; it predicts the establishment of a steady state, during which the emerging concentrations of the pollutants remain constant. One method to remove cyanotoxins produced by Microcystis cyanobacteria, which pose a threat at concentrations above 1.0 µg L−1, is to use an activated granular carbon filter with a biofilm; this method resulted in the complete removal of the filtered toxins (5 µg L−1) during a long experiment (225 d). This system was analyzed using a model which predicted complete toxin removal when applied at a 10-fold-higher concentration. Enzymes are also used in filtration processes for the degradation of trace organic contaminants, mostly through the use of membrane bioreactors, where the enzyme is continuously introduced or maintained in the bioreactor, or it is immobilized on the membrane.

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Section: Membrane Technologiesmentioning

confidence: 99%

Removal of Emerging Contaminants by Degradation during Filtration: A Review of Experimental Procedures and Modeling

Undabeytia,

Jiménez-Barrera,

Nir

2023

Water

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“…Enzyme immobilization consists in confining an enzyme in a defined region of space. Immobilization can be performed at the reactor scale by use of various membrane technologies that allow separation of the enzyme from a liquid reaction medium . Nevertheless, the most technically useful meaning of immobilization implies heterogenization of the catalytic reaction, where the enzyme is rendered insoluble by incorporation onto or into a solid matrix.…”

Section: Enzyme Immobilization As a Core Technologymentioning

confidence: 99%

An Overview of Cytochrome P450 Immobilization Strategies for Drug Metabolism Studies, Biosensing, and Biocatalytic Applications: Challenges and Opportunities

2021

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Cytochrome P450s (P450s or CYPs) are a large superfamily of ubiquitous heme proteins. Consistent with their natural roles in oxidative metabolism of a broad range of substrates including antibiotics and xenobiotics and in the biosynthesis of complex natural products, there are two main biotechnological applications: drug metabolism studies and biocatalytic transformations. Metabolic analyses are typically performed with the P450 enzyme immobilized on a biosensing platform. Biocatalytic reactions also increasingly make use of immobilization methods with the goal of improving operational stability of the P450s. In this Review, we briefly introduce the growing field of enzyme immobilization then focus on the advances, benefits, and challenges that apply specifically to P450s. Classical immobilization methods are presented, and recently developed materials and strategies that address the need for operational stability, the multicomponent structure of P450s, their requirement for a source of electrons, and the need to overcome limited O 2 availability are discussed in the context of metabolic, biosensing, and biocatalytic applications.

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“…The synthesis of GOS within an enzymatic membrane reactor (EMR) offers great potential because there is no further need for additional investments in new technologies, since membrane technology is an established and essential part of dairy industry. Moreover, membrane units are modular designed simplifying the scale-up [10]. However, wellfounded knowledge is necessary to design the process, which is based on a complex interplay of different key factors including membrane and solute properties, operating synthesis parameters and their interactions with enzyme activity [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Potential of Integrated Semi‐Continuous Enzymatic Synthesis and Filtration Processes for Efficiency Enhancement

Hofmann

Hamel

2023

Chemie Ingenieur Technik

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Galacto‐oligosaccharides (GOS), increasingly popular prebiotics, are synthesized by enzymatic conversion of lactose. Among others, the total production costs are significantly influenced by the costly enzyme. Therefore, it was investigated if the reuse and full recovery of the enzyme is feasible, followed by the development of a semi‐continuous process in order to maintain a consistent high GOS yield. As a preliminary step, the enzyme‐catalyzed reaction was recorded within the permissible operating parameters. It was successfully shown that steady high GOS yields can be synthesized semi‐continuously within a filtration plant functioning as an enzymatic membrane reactor.

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Biocatalytic membrane reactors (BMR)

Cited by 6 publications

References 144 publications

Removal of Emerging Contaminants by Degradation during Filtration: A Review of Experimental Procedures and Modeling

Removal of Emerging Contaminants by Degradation during Filtration: A Review of Experimental Procedures and Modeling

An Overview of Cytochrome P450 Immobilization Strategies for Drug Metabolism Studies, Biosensing, and Biocatalytic Applications: Challenges and Opportunities

Potential of Integrated Semi‐Continuous Enzymatic Synthesis and Filtration Processes for Efficiency Enhancement

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