Biocatalysis as Key to Sustainable Industrial Chemistry

Alcántara, Andrés R.; Marı́a, Pablo Domı́nguez de; Littlechild, Jennifer A.; Schürmann, Martin; Sheldon, Roger A.; Wohlgemuth, Roland

doi:10.1002/cssc.202102709

Cited by 66 publications

(50 citation statements)

References 107 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The evolution of the synthesis of Merck’s Januvia nicely exemplifies the impact offered by these scientific and technical achievements (Scheme ). , There is little doubt that merging both forms of catalysis will create additional opportunities, which may already have been generated in proprietary fashion in various industries.…”

Section: Discussionmentioning

confidence: 99%

Where Chemocatalysis Meets Biocatalysis: In Water

2022

View full text Add to dashboard Cite

Chemoenzymatic catalysis, by definition, involves the merging of sequential reactions using both chemocatalysis and biocatalysis, typically in a single reaction vessel. A major challenge, the solution to which, however, is associated with numerous advantages, is to run such one-pot processes in water: the majority of enzyme-catalyzed processes take place in water as Nature’s reaction medium, thus enabling a broad synthetic diversity when using water due to the option to use virtually all types of enzymes. Furthermore, water is cheap, abundantly available, and environmentally friendly, thus making it, in principle, an ideal reaction medium. On the other hand, most chemocatalysis is routinely performed today in organic solvents (which might deactivate enzymes), thus appearing to make it difficult to combine such reactions with biocatalysis toward one-pot cascades in water. Several creative approaches and solutions that enable such combinations of chemo- and biocatalysis in water to be realized and applied to synthetic problems are presented herein, reflecting the state-of-the-art in this blossoming field. Coverage has been sectioned into three parts, after introductory remarks: (1) Chapter 2 focuses on historical developments that initiated this area of research; (2) Chapter 3 describes key developments post-initial discoveries that have advanced this field; and (3) Chapter 4 highlights the latest achievements that provide attractive solutions to the main question of compatibility between biocatalysis (used predominantly in aqueous media) and chemocatalysis (that remains predominantly performed in organic solvents), both Chapters covering mainly literature from ca. 2018 to the present. Chapters 5 and 6 provide a brief overview as to where the field stands, the challenges that lie ahead, and ultimately, the prognosis looking toward the future of chemoenzymatic catalysis in organic synthesis.

show abstract

Section: Discussionmentioning

confidence: 99%

Where Chemocatalysis Meets Biocatalysis: In Water

2022

View full text Add to dashboard Cite

show abstract

“…The synthesis of phosphometabolites has progressed very well and numerous phosphometabolites have become accessible in pure form for the first time. Nevertheless, there is much more work ahead for developing scalable syntheses of known and novel phosphometabolites, reducing the complexity of synthetic routes [ 149 ], improving the molecular economy, and enabling sustainable phosphorus chemistry [ 150 ].…”

Section: Discussionmentioning

confidence: 99%

Advances in the Synthesis and Analysis of Biologically Active Phosphometabolites

Wohlgemuth

2023

IJMS

View full text Add to dashboard Cite

Phosphorus-containing metabolites cover a large molecular diversity and represent an important domain of small molecules which are highly relevant for life and represent essential interfaces between biology and chemistry, between the biological and abiotic world. The large but not unlimited amount of phosphate minerals on our planet is a key resource for living organisms on our planet, while the accumulation of phosphorus-containing waste is associated with negative effects on ecosystems. Therefore, resource-efficient and circular processes receive increasing attention from different perspectives, from local and regional levels to national and global levels. The molecular and sustainability aspects of a global phosphorus cycle have become of much interest for addressing the phosphorus biochemical flow as a high-risk planetary boundary. Knowledge of balancing the natural phosphorus cycle and the further elucidation of metabolic pathways involving phosphorus is crucial. This requires not only the development of effective new methods for practical discovery, identification, and high-information content analysis, but also for practical synthesis of phosphorus-containing metabolites, for example as standards, as substrates or products of enzymatic reactions, or for discovering novel biological functions. The purpose of this article is to review the advances which have been achieved in the synthesis and analysis of phosphorus-containing metabolites which are biologically active.

show abstract

“… 2 , 5 , 6 The idea that the use of enzymes as catalysts is just an academic speculation belongs to the past, and biocatalysis is now recognized as a highly valuable tool for cost‐effective and sustainable pharmaceutical manufacturing. 7 , 8 Several advantages are associated with biocatalysis, 5 such as the use of biodegradable enzymatic catalysts, the limited number of synthetic steps, the mild reaction conditions, and the high enantio‐, chemo‐ and regioselectivities. 6 , 9 , 10 , 11 Nevertheless, its potential is not yet fully exploited.…”

Section: Introductionmentioning

confidence: 99%

Biocatalysis: A smart and green tool for the preparation of chiral drugs

et al. 2022

View full text Add to dashboard Cite

Over the last decades, biocatalysis has achieved growing interest thanks to its potential to enable high efficiency, high yield, and eco-friendly processes aimed at the production of pharmacologically relevant compounds. Particularly, biocatalysis proved an effective and potent tool in the preparation of chiral molecules, and the recent innovations of biotechnologies and nanotechnologies open up a new era of further developments in this field. Different strategies are now available for the synthesis of chiral drugs and their intermediates. Enzymes are green tools that offer several advantages, associated both to catalysis and environmentally friendly reactants. Specifically, the use of enzymes isolated from biological sources or of whole-cell represents a valuable approach to obtain pharmaceutical products. The sustainability, the higher efficiency, and cost-effectiveness of biocatalytic reactions result in improved performance and properties that can be translated from academia to industry. In this review, we focus on biocatalytic approaches for synthesizing chiral drugs or their intermediates. Aiming to unveil the potentialities of biocatalysis systems, we discuss different examples of innovative biocatalytic approaches and their applications in the pharmaceutical industry.

show abstract

Biocatalysis as Key to Sustainable Industrial Chemistry

Cited by 66 publications

References 107 publications

Where Chemocatalysis Meets Biocatalysis: In Water

Where Chemocatalysis Meets Biocatalysis: In Water

Advances in the Synthesis and Analysis of Biologically Active Phosphometabolites

Biocatalysis: A smart and green tool for the preparation of chiral drugs

Contact Info

Product

Resources

About