BioCartilage Improves Cartilage Repair Compared With Microfracture Alone in an Equine Model of Full-Thickness Cartilage Loss

Fortier, Lisa A.; Chapman, Hannah S.; Pownder, Sarah L.; Roller, Brandon L.; Cross, Jessica A.; Cook, James L.; Cole, Brian J.

doi:10.1177/0363546516648644

Cited by 107 publications

(82 citation statements)

References 16 publications

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“…The addition of a micronized allogeneic cartilage scaffold has been shown to yield higher rates of hyaline cartilage formation in animal studies when compared with microfracture alone. 6,16 Our expectation is that a minimally invasive technique that promotes the formation of a more hyaline-like cartilage may result in a more durable surface and subsequent superior long-term results. 6 To date, no results are available on arthroscopic debridement, drilling, and supplementation of BioCartilage, 6 and further clinical studies will be needed to determine the long-term efficacy of this technique.…”

Section: Discussionmentioning

confidence: 99%

Arthroscopic Treatment of Capitellum Osteochondritis Dissecans With Micronized Allogeneic Cartilage Scaffold

Caldwell

Auerbach

Pearson

2017

Arthroscopy Techniques

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Osteochondritis dissecans (OCD) of the capitellum is a common disorder that causes pain and functional limitation in the adolescent elbow. Although conservative management is the first line of treatment, surgical intervention is usually recommended for patients with persistent mechanical symptoms, loose bodies, or unstable lesions. Elbow arthroscopy has become the gold standard to evaluate and treat symptomatic OCD lesions. Arthroscopic debridement and bone marrow stimulation have been shown to yield good short-term results. Unfortunately, long-term follow-up has shown less favorable outcomes, with degenerative changes frequently documented. Current marrow stimulation techniques promote the formation of fibrocartilage, which is known to be less durable than hyaline cartilage. We describe an arthroscopic technique of debridement and drilling supplemented with a micronized allogeneic cartilage scaffold to address OCD lesions of the capitellum in an effort to promote hyaline cartilage formation.

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Section: Discussionmentioning

confidence: 99%

Arthroscopic Treatment of Capitellum Osteochondritis Dissecans With Micronized Allogeneic Cartilage Scaffold

Caldwell

Auerbach

Pearson

2017

Arthroscopy Techniques

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“…In addition, PRP has been used to augment the surgical management of articular cartilage defects, with encouraging preclinical results reported. 66,96,97 For this augmented procedure, a commercially available biologic scaffold of micronized allograft articular cartilage matrix is aug-mented with PRP and placed in the defect bed after microfracture to induce type II hyaline cartilage rather than the type I fibrocartilage typically produced via traditional marrow stimulation techniques.…”

Section: Role Of Biologic Therapymentioning

confidence: 99%

The Utility of Biologics, Osteotomy, and Cartilage Restoration in the Knee

Frank

Cotter

Strauss

et al. 2018

J Am Acad Orthop Surg

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The management of complex cartilage and meniscal pathology in young, athletic patients is extremely challenging. Joint preservation surgery is most difficult in patients with concomitant knee pathologies, including cartilage defects, meniscal deficiency, malalignment, and/or ligamentous insufficiency. Clinical decision making for these patients is further complicated by articular cartilage lesions, which often are incidental findings; therefore, treatment decisions must be based on the confirmed contribution of articular cartilage lesions to symptomatology. Surgical management of any of the aforementioned knee pathologies that is performed in isolation typically results in acceptable patient outcomes; however, concomitant procedures for the management of concomitant knee pathologies often are essential to the success of any single procedure. The use of biologic therapy as an alternative to or to augment more conventional surgical management has increased in popularity in the past decade, and indications for biologic therapy continue to evolve. Orthopaedic surgeons should understand knee joint preservation techniques, including biologic and reconstructive approaches in young, high-demand patients.

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“…It contains an allogeneic extracellular matrix and includes type II collagen, proteoglycans, and cartilaginous growth factors. Fortier et al [87] reported that BioCartilage with PRP safely improved cartilage repair compared with microfracture alone in an equine model with up to 13 months of follow-up. In clinical studies, Desai et al [88] reported a case series of nine patients with an average lesion size of 132 mm 2 .…”

Section: Cartilage Allograftmentioning

confidence: 99%

Osteochondral lesions of the talus in the athlete: up to date review

Shimozono

Yasui

Ross

et al. 2017

Curr Rev Musculoskelet Med

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Purpose of review Osteochondral lesions of the talus (OLT) are common injuries in athletes. The purpose of this study is to comprehensively review the clinical results and return to sport capacity in athletes following treatment for OLT. Recent findings Reparative procedures, such as bone marrow stimulation, and replacement procedures, such as autologous osteochondral transplantation, provide good clinical outcomes in short-and mid-term follow-up in the athlete. Recently, biological augmentation and scaffold-based therapies have been shown to improve clinical and radiological outcomes in OLT in both the general population and athletes. Summary Most studies are of a low level of evidence. Studies analyzing the return to sport capability in athletes are further lacking. High-level evidence and well-designed clinical trials are required to establish the most effective treatment protocol.

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BioCartilage Improves Cartilage Repair Compared With Microfracture Alone in an Equine Model of Full-Thickness Cartilage Loss

Abstract: The 1-year results of BioCartilage + PRP suggest that homologous allograft tissue provides a safe and effective augmentation of traditional MFx.

Cited by 107 publications

References 16 publications

Arthroscopic Treatment of Capitellum Osteochondritis Dissecans With Micronized Allogeneic Cartilage Scaffold

Arthroscopic Treatment of Capitellum Osteochondritis Dissecans With Micronized Allogeneic Cartilage Scaffold

The Utility of Biologics, Osteotomy, and Cartilage Restoration in the Knee

Osteochondral lesions of the talus in the athlete: up to date review

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