Biobanking for Translational Diabetes Research in India

Abstract

India is declared as the diabetic capital of the world. Clinically well-annotated blood samples will advance diabetes research for better diagnostic and treatment methods. Building a disease-specific biobank with highquality peripheral blood mononuclear cells (PBMCs) and clinical follow-up data system will serve as a good platform for clinical research in diabetes. Processing and storage of high-quality biospecimen for translational research in diabetes demand the implementation of good clinical laboratory practices. ''Certification or accreditation programs'' that improve biorepository processes and frameworks are lacking in Indian context. To sustain and translate the research into clinical practice, good governance of the biobank and financial resources is required. For ethical issues related to health needs of the people and participants in the research, issues related to research process, translational research, and commercialization, data sharing should be addressed. For India to be an innovation and sustainable country Indian government is supporting translational research facilities, including biobanks. India has developed biobanks for various diseases; however, diabetes-specific research biorepository is lacking. Given the dangers of diabetic burden, India should set up a diabetes disease-specific repository learning from the global organizations and customize to the needs of Indian context. It is important to have private agencies get involved to develop biobanks and future research as there are commercial goals to translate research into practice. New technologies of specimen storing and preservation, data management, and data sharing should be adopted for developing cost-effective long-standing disease-specific population biobank in India.

A Strategic Research Framework for Defeating Diabetes in India: A 21st-Century Agenda

“…India has developed biobanks for diseases, such as cancer, brain disorders and liver diseases, but a biobank for diabetes research is lacking, and there is limited spare capacity beyond the needs of studies that receive funding to set them up. 128 Integration of such biobanks with electronic health records may provide an avenue for novel insights into disease etiology among Indians. This requires an extensive effort for transdisciplinary research and collaboration across medical and basic biological institutions.…”

Biobanking potential for biomedical research in endocrinology

“…На стадии планирования и разработки находится диабет-ориентированный биобанк в Индии [12]. Одной из целей его организации является проведение современных исследований, направленных на поиск молекулярных маркеров-предикторов высокого риска возникновения СД и развития осложнений.…”

“…Уже на этапе сбора биологического материала остро встает вопрос о строгом соблюдении всех требований, относящихся к работе с биообразцами: объем биоматериала, подбор оборудования, температурный режим, временные промежутки каждого преаналитического этапа [12]. Это важно для минимизации погрешности и получения достоверных, воспроизводимых результатов, в связи с чем партнерство с биорепозиториями в рамках эндокринологических исследований является оптимальным решением.…”