Bioavailable testosterone is associated with symptoms of depression in adult men

Chen, Zhongbao; Shen, Xubo; Tian, Kunming; Liu, Yijun; Xiong, Shimin; Yu, Qing; Dai, Lulu; Shi, Yongjun; Zhang, Renjuan; Zeng, Rong; Wan, Qiyou; Xiong, Chengliang; Zhou, Yuanzhong

doi:10.1177/0300060520941715

Cited by 12 publications

(15 citation statements)

References 47 publications

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“…27 As a result, our future research will likely focus on the lower levels of neuroactive steroids in certain regions of the brain, that has been observed previously to induce depression-like behavior. The findings of the previous study 28 revealed that repeated administration of finasteride for 7 days reduced hippocampal neurogenesis in rats.…”

Section: Discussionmentioning

confidence: 85%

The effects of methylated flavonoids on depression-like activity and pro-inflammatory cytokine thresholds in mice induced by repeated finasteride administration

She

Xie

et al. 2021

Eur J Inflamm

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The aim of the study was to investigate the influence of naringenin (NGN) and its methylated derivatives (50 or 100 mg kg−1) on finasteride-caused depression-like performance in mice to identify the effects on behavior and biomarkers of inflammation in the management of depression. Depression-like behavior was induced by repeated dose of finasteride (100 mg kg−1, subcutaneously) in mice. The effects of the naringenin (50 or 100 mg kg−1) or its methylated derivatives (Ngn-M; 50 or 100 mg kg−1 or Ngn-DM; 50 or 100 mg kg−1) and duloxetine (DXT, 10 mg kg−1) were evaluated for the immobility time in tail suspension and forced swimming tests following finasteride pre-treatment. The levels of brain pro-inflammatory cytokines such as IL-1β and TNF-α were also measured by Enzyme-Linked Immunosorbent Assay to further evaluate the impact of naringenin and its methylated derivatives on inflammation. Pre-treatment with finasteride substantially increased both the immobility time spent in tail suspension and forced swimming tests and brain levels of IL-1β and TNF–α in mice. Doluxetine (DLX) was given at a dose of 10 mg kg−1, and Naringenin or its methylated derivatives were given at doses of 50 and 100 mg kg−1 orally. It reduced immobility time in both tests, restored the preference to sucrose solution, and normalized cytokine levels (p < 0.01) in mice. Similar effects were observed with DTX (10 mg kg−1) as positive control. The increased brain levels of malondialdehyde (MDA) or nitrite were considerably (p < 0.05) decreased while substantially (p < 0.05) increased glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) levels after finasteride pre-treatment relative to vehicle-control by naringenin or its methylated derivatives (50 or 100 mg kg−1). These findings demonstrated the potential for methylated flavonoids as safe and effective anti-depressive agents.

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Section: Discussionmentioning

confidence: 85%

The effects of methylated flavonoids on depression-like activity and pro-inflammatory cytokine thresholds in mice induced by repeated finasteride administration

She

Xie

et al. 2021

Eur J Inflamm

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“…Anti-inflammatory cytokines IL-10 and IL-4 and pro-inflammatory cytokines IL-1 β , IL-6, and TNF- α play a vital role in the occurrence and development of inflammation diseases [ 36 , 37 ]. A survey showed that the level of T in patients with depression was lower than that in normal people [ 38 ]. Furthermore, both preclinical evidence and clinical evidence showed that the low level of NPY directly led to a variety of mental illnesses, including depression and related diseases [ 39 – 41 ].…”

Section: Discussionmentioning

confidence: 99%

Baicalin Attenuates Continuous Activation of β-Catenin Induced by Lipopolysaccharide (LPS) and Depression Complicated by Infertility in Male Rats

Fan

Ding

Zhang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background. Baicalin (BA) is a potential candidate drug to inhibit depressive behavior. However, the mechanism of BA's role on depression complicated with male infertility (DCMI) is still unclear. This study aimed to investigate the role of BA in alleviating inflammatory factor-induced DCMI by regulating β-catenin. Methods. Firstly, we performed sucrose preference test (SPT), open field test (OFT), tail suspension test (TST), and forced swim test (FST) in the chronic unpredictable mild stress (CUMS) + lipopolysaccharide (LPS) model rats to study the effect of BA on depressive behavior. The levels of neuropeptide Y (NPY), testosterone (T), and IL-1β, IL-6, TNF-α, IL-10, and IL-4 in the peripheral blood plasma of normal people, patients with depression, and patients with DCMI were measured. Then, the levels of IL-1β, IL-6, TNF-α, IL-10, IL-4, β-catenin in rat testis and peripheral blood and ANXA2, APP, SEMG1, and SEMG2 in seminal plasma proteins were examined. Moreover, the level of β-catenin in the testicular tissue was detected. LPS was used to treat Sertoli cells, and the level of β-catenin was detected. Finally, we evaluated the reproductive phenotype and sperm motility of rats. Results. BA (especially 100 mg/kg) could notably ameliorate depression-like behavior induced by CUMS + LPS. The levels of IL-4, IL-10, T, and NPY in depression patients, DCMI patients, and CUMS + LPS model rats elevated, while the levels of IL-1β, IL-6, and TNF-α were reduced. However, BA alleviated the changes in these factors. Moreover, BA alleviated male rat depression induced by CUMS + LPS. LPS upregulated β-catenin (NP) but could not adjust β-catenin (TP) level in rat Sertoli cells. BA relieved the symptoms of DCMI by regulating β-catenin. Furthermore, BA ameliorated the reproductive ability of depressed rats. Conclusion. BA modulated β-catenin in the relief of inflammatory factor-induced DCMI.

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“…Second, because serum testosterone was not a static but a dynamic variable, measuring testosterone only once may cause some bias in testosterone levels used in the analysis. Third, in men's circulating plasma testosterone, approximately 2% to 3% is in free form, 33% to 54% is bound to albumin, and 44% to 65% is bound to sex hormone binding globulin, which loses its biological activity because of tight binding [ 32 ]. Bioavailable testosterone levels are not completely associated with testosterone levels.…”

Section: Discussionmentioning

confidence: 99%

Association between Serum Testosterone Levels and Body Composition among Men 20–59 Years of Age

Zhai

Yang

et al. 2021

International Journal of Endocrinology

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Introduction. Sex hormones play an important role in the development and maintenance of bone and muscle mass. However, studies regarding serum testosterone levels, osteoporosis, and sarcopenia in men are relatively sparse and have led to contradictory conclusions. Therefore, this study aimed to investigate the association between serum testosterone levels and body composition, including bone mineral density (BMD), appendicular lean mass index (ALMI), and appendicular fat mass index (AFMI), among men 20–59 years of age through a cross-sectional analysis of the National Health and Nutrition Examination Survey. Materials and Methods. Our analysis was based on the data for 3,875 men, 20–59 years of age. Weighted multiple regression analyses were used to estimate the independent association between serum testosterone levels and body composition. Weighted generalized additive models and smooth curve fittings were used to characterize the nonlinear associations between them. Results. The association between the serum testosterone level and lumbar BMD was positive in each multivariable linear regression model. In the model adjusted for age and race, the serum testosterone level was negatively associated with ALMI. However, in the models adjusted for body mass index, this association became positive. In addition, the association between the serum testosterone level and AFMI was negative in each multivariable linear regression model. Conclusion. Our study demonstrated a positive association of serum testosterone level with lumbar BMD and ALMI, and a negative association with AFMI, among men 20–59 years of age, suggesting that increasing testosterone levels may be beneficial to skeletal health in young and middle-aged men with low testosterone levels.

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Bioavailable testosterone is associated with symptoms of depression in adult men

Cited by 12 publications

References 47 publications

The effects of methylated flavonoids on depression-like activity and pro-inflammatory cytokine thresholds in mice induced by repeated finasteride administration

The effects of methylated flavonoids on depression-like activity and pro-inflammatory cytokine thresholds in mice induced by repeated finasteride administration

Baicalin Attenuates Continuous Activation of β-Catenin Induced by Lipopolysaccharide (LPS) and Depression Complicated by Infertility in Male Rats

Association between Serum Testosterone Levels and Body Composition among Men 20–59 Years of Age

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