Bioavailability, Toxicity, and Bioaccumulation of Quantum Dot Nanoparticles to the Amphipod<i>Leptocheirus plumulosus</i>

Jackson, Brian P.; Buggé, Deenie M.; Ranville, James F.; Chen, Celia Y.

doi:10.1021/es202864r

Cited by 92 publications

(58 citation statements)

References 40 publications

(78 reference statements)

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“…Amphipods are known to ingest up to three times their body weight in sediment per day (Schlekat et al, 2000). Uptake of quantum dots via ingestion was shown previously for L. plumulosus (Jackson et al, 2012). Amphipods are an important food source for many marine birds, fish, and invertebrates and thus may contribute to the accumulation of these contaminants in other organisms that may otherwise not be exposed to them.…”

Section: Discussionmentioning

confidence: 90%

Accumulation and toxicity of metal oxide nanoparticles in a soft-sediment estuarine amphipod

et al. 2013

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a b s t r a c tEstuarine and marine sediments are a probable end point for many engineered nanoparticles (ENPs) due to enhanced aggregation and sedimentation in marine waters, as well as uptake and deposition by suspension-feeding organisms on the seafloor. Benthic infaunal organisms living in sediments encounter relatively high concentrations of pollutants and may also suffer toxic effects of ENPs. We tested whether three heavily used metal oxide ENPs, zinc oxide (ZnO), copper oxide (CuO), and nickel oxide (NiO) were toxic to an estuarine amphipod, Leptocheirus plumulosus. We used results from 10-day laboratory bioassays to estimate potential demographic impacts of ENP exposure. We also evaluated fate and transport pathways of the ENPs in the experiments to elucidate routes of uptake and exposure. Dissolved Zn was found in sediment pore water and overlying water samples at 10 fold the concentrations of Cu or Ni, a pattern indicative of the relatively high dissolution rate of ZnO ENPs compared with CuO and NiO ENPs. Accumulation of metals in amphipod tissues increased with exposure concentrations for all three ENPs, suggesting possible exposure pathways to higher taxa. Amphipods accumulated ≤600 g Zn and Cu g −1 and 1000 g Ni g −1 . Amphipod mortality increased with ZnO and CuO concentrations, but showed no significant increase with NiO to concentrations as high as 2000 g g −1 . The median lethal concentration in sediment (LC 50 ) of ZnO was 763 g g −1 and 868 g g −1 for CuO ENPs. Our results indicate that ZnO and CuO ENPs, but not NiO ENPs, are toxic to L. plumulosus and that ZnO toxicity primarily results from Zn ion exposure while CuO toxicity is due to nanoparticle exposure.

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Section: Discussionmentioning

confidence: 90%

Accumulation and toxicity of metal oxide nanoparticles in a soft-sediment estuarine amphipod

et al. 2013

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“…Additionally, QDs have been shown to remain in major organs for months after injection producing immunogenic reactions in vivo [352][353][354][355]. Iodinated agents are also less than ideal because of their biological toxicity and short circulation time in vivo [356][357][358].…”

Section: Imagingmentioning

confidence: 99%

Controllable Cobalt Oxide/Au Hierarchically Nanostructured Electrode for Nonenzymatic Glucose Sensing

2016

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By electrodeposition and galvanic replacement reaction, we developed a facile, time-saving, cost-effective, and environmentally friendly, two-step synthesis route to obtain a controllable cobalt oxide/Au hierarchically nanostructured electrode for glucose sensing. The nanomaterials were characterized by transmission electron microscopy, scanning electron microscopy, Raman spectroscopy, energy-dispersive spectrometry, and X-ray photoelectron spectroscopy, meanwhile, the sensing performance was investigated by cyclic voltammetry and amperometric response. The results revealed that this novel electrode exhibited excellent electrocatalytic performance toward glucose oxidation, with a wide double-linear range from 0.2 μM to 20 mM and a low detection limit of 0.1 μM based on a signal-to-noise ratio of 3, which was mainly attributed to the ability of loading a small amount of Au with good electron conductivity on the surface of cobalt oxide nanosheets with large active surface area and synergistic electrocatalytic activity of Au and cobalt oxide toward glucose electrooxidation. This facile, sensitive, and selective glucose sensor is also proven to be suitable for the detection of glucose in human serum.

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“…[1][2][3][4][5] The toxicity of NPs is theoretically expected to be different from that of traditional materials because of their extremely small size and high surface-volume ratio, and thus raises many concerns about the potential risks of human exposure. The NPs toxicity to organisms might be attributed to three main causes, namely, the presence of NPs, the release of soluble ions, and the generation of free radicals.…”

Section: Introductionmentioning

confidence: 99%

An integrated study on antimicrobial activity and ecotoxicity of quantum dots and quantum dots coated with the antimicrobial peptide indolicidin

Galdiero¹,

Siciliano²,

Maselli³

et al. 2016

IJN

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This study attempts to evaluate the antimicrobial activity and the ecotoxicity of quantum dots (QDs) alone and coated with indolicidin. To meet this objective, we tested the level of antimicrobial activity on Gram-positive and Gram-negative bacteria, and we designed an ecotoxicological battery of test systems and indicators able to detect different effects using a variety of end points. The antibacterial activity was analyzed against Staphylococcus aureus (ATCC 6538), Pseudomonas aeruginosa (ATCC 1025), Escherichia coli (ATCC 11229), and Klebsiella pneumoniae (ATCC 10031), and the results showed an improved germicidal action of QDs-Ind. Toxicity studies on Daphnia magna indicated a decrease in toxicity for QDs-Ind compared to QDs alone, lack of bioluminescence inhibition on Vibrio fisheri , and no mutations in Salmonella typhimurium TA 100 . The comet assay and oxidative stress experiments performed on D. magna showed a genotoxic and an oxidative damage with a dose–response trend. Indolicidin retained its activity when bound to QDs. We observed an enhanced activity for QDs-Ind. The presence of indolicidin on the surface of QDs was able to decrease its QDs toxicity.

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Bioavailability, Toxicity, and Bioaccumulation of Quantum Dot Nanoparticles to the AmphipodLeptocheirus plumulosus

Cited by 92 publications

References 40 publications

Accumulation and toxicity of metal oxide nanoparticles in a soft-sediment estuarine amphipod

Accumulation and toxicity of metal oxide nanoparticles in a soft-sediment estuarine amphipod

Controllable Cobalt Oxide/Au Hierarchically Nanostructured Electrode for Nonenzymatic Glucose Sensing

An integrated study on antimicrobial activity and ecotoxicity of quantum dots and quantum dots coated with the antimicrobial peptide indolicidin

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Bioavailability, Toxicity, and Bioaccumulation of Quantum Dot Nanoparticles to the AmphipodLeptocheirus plumulosus

Cited by 92 publications

References 40 publications

Accumulation and toxicity of metal oxide nanoparticles in a soft-sediment estuarine amphipod

Accumulation and toxicity of metal oxide nanoparticles in a soft-sediment estuarine amphipod

Controllable Cobalt Oxide/Au Hierarchically Nanostructured Electrode for Nonenzymatic Glucose Sensing

An integrated study on antimicrobial activity and ecotoxicity of&nbsp;quantum dots&nbsp;and&nbsp;quantum dots&nbsp;coated with the antimicrobial peptide indolicidin

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An integrated study on antimicrobial activity and ecotoxicity of quantum dots and quantum dots coated with the antimicrobial peptide indolicidin