Bioavailability study of triamterene and xipamide using urinary pharmacokinetic data following single oral dose of each drug or their combination

Maher, Hadir M.; Youssef, Rasha M.; El-Kimary, Eman I.; Hassan, Ekram M.; Barary, Magda A.

doi:10.1016/j.jpba.2011.11.032

Cited by 23 publications

(13 citation statements)

References 20 publications

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“…For all three analytes, the model accuracy obtained from standard solutions within the linearity range covers the interval of 97 to 102 % (Table II). When the results of the method for determination of the three analytes were statistically compared with those obtained from the reported HPLC methods (7,24), it was found that there was no signifi cant diff erence between them regarding accuracy and precision, since the calculated t-and F-values were lower than the corresponding tabulated ones (Table V).…”

Section: Accuracy Of the New Methods And Application For Analysis Of Xmentioning

confidence: 93%

“…Several procedures have been developed for its determination, which include spectrophotometry (3)(4)(5), spectrofl uorimetry (5,6), TLC-densitometry (4) and HPLC (7)(8)(9)(10)(11)(12).…”

mentioning

confidence: 99%

“…Literature survey reveals that TRI has been determined by spectrophotometric (4,(14)(15)(16)(17)(18), fl uorimetric (19,20) and chromatographic (7,21,22) methods.…”

mentioning

confidence: 99%

“…Literature review revealed that a few methods were developed for determination of XIP and TRI together (4,7) or TRI with HCT (15)(16)(17)21); however, these methods suff er either from low sensitivity or long separation time. In addition, the single-pill, triple-combination antihypertensive therapy has been widely accepted as an eff ective, well-tolerated, and convenient strategy that can help hypertensive patients (27).…”

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confidence: 99%

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High performance liquid chromatography for simultaneous determination of xipamide, triamterene and hydrochlorothiazide in bulk drug samples and dosage forms

2016

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A novel, simple and robust high-performance liquid chromatography (HPLC) method was developed and validated for simultaneous determination of xipamide (XIP), triamterene (TRI) and hydrochlorothiazide (HCT) in their bulk powders and dosage forms. Chromatographic separation was carried out in less than two minutes. The separation was performed on a RP C-18 stationary phase with an isocratic elution system consisting of 0.03 mol L -1 orthophosphoric acid (pH 2.3) and acetonitrile (ACN) as the mobile phase in the ratio of 50:50, at 2.0 mL min -1 fl ow rate at room temperature. Detection was performed at 220 nm. Validation was performed concerning system suitability, limits of detection and quantitation, accuracy, precision, linearity and robustness. Calibration curves were rectilinear over the range of 0.195-100 μg mL -1 for all the drugs studied. Recovery values were 99.9, 99.6 and 99.0 % for XIP, TRI and HCT, respectively. The method was applied to simultaneous determination of the studied analytes in their pharmaceutical dosage forms.

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Section: Accuracy Of the New Methods And Application For Analysis Of Xmentioning

confidence: 93%

“…Several procedures have been developed for its determination, which include spectrophotometry (3)(4)(5), spectrofl uorimetry (5,6), TLC-densitometry (4) and HPLC (7)(8)(9)(10)(11)(12).…”

mentioning

confidence: 99%

“…Literature survey reveals that TRI has been determined by spectrophotometric (4,(14)(15)(16)(17)(18), fl uorimetric (19,20) and chromatographic (7,21,22) methods.…”

mentioning

confidence: 99%

mentioning

confidence: 99%

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High performance liquid chromatography for simultaneous determination of xipamide, triamterene and hydrochlorothiazide in bulk drug samples and dosage forms

2016

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“…Therefore, simultaneous determination of the analytes in biological samples is important in studying pharmacokinetics. However, to our best knowledge, no analytical method has been described in the literature which simultaneously determines these three analytes in biological samples, even though several methods exist, which separately determine either triamterene [1][2][3][4][5], hydrochlorothiazide [6][7][8], reserpine [9][10][11][12][13], or determine triamterene and hydrochlorothiazide simultaneously [14,15]. Though many kinds of analytical methods such as spectrophotometry, spectrofluorimetric, potentiometry, capillary electrophoresis, HPLC-UV, LC-MS were used in these literatures, it is tedious to determine three analytes separately for each sample using two different HPLC conditions or even two different detection methods.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Analysis of Hydrochlorothiazide, Triamterene and Reserpine in Rat Plasma by HPLC and DSPE

et al. 2016

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Two liquid chromatographic approaches for the simultaneous determination of xipamide and its degradation product (2,6‐xylidine) using time‐programmed fluorescence detection

Tolba

Belal

2016

Luminescence

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A study of the performance of reversed-phase chromatography with a programmable multiwavelength fluorimetric technique using either conventional hydro-organic or micellar eluent is established for the determination of xipamide (XIP) in the presence of its degradation product, 2,6-xylidine (XY). In conventional liquid chromatography (CLC), the analyses were carried out on a Promosil ODS 100 Å column (250 mm × 4.6 mm i.d., 5 μm) using a mobile phase consisting of methanol/0.1 M phosphate buffer (65: 35, v/v) at pH 4.0. For micellar liquid chromatography (MLC), a short Spherisorb column (150 mm × 4.6 mm i.d., 5 μm) was employed in conjunction with a greener mobile phase (pH 5.0) containing 0.1 M sodium dodecyl sulfate and 15% n-propanol. CLC proved to be superior to MLC in terms of sensitivity for the determination of the degradation product because it could detect trace amounts down to 10.0 ng/ml of XY as a degradation product in XIP. However, MLC represents an eco-friendly approach for the simultaneous determination of XIP and XY. In addition, the opportunity for the direct introduction of biological matrices into the chromatographic system is one of the distinctive benefits of MLC. The proposed methods were applied for the determination of XIP in its tablets, human urine and content uniformity testing. The results of the proposed methods were statistically compared with those obtained using the comparison fluorimetric method, revealing no significant differences in the performance of the methods regarding accuracy and precision.

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Bioavailability study of triamterene and xipamide using urinary pharmacokinetic data following single oral dose of each drug or their combination

Cited by 23 publications

References 20 publications

High performance liquid chromatography for simultaneous determination of xipamide, triamterene and hydrochlorothiazide in bulk drug samples and dosage forms

High performance liquid chromatography for simultaneous determination of xipamide, triamterene and hydrochlorothiazide in bulk drug samples and dosage forms

Simultaneous Analysis of Hydrochlorothiazide, Triamterene and Reserpine in Rat Plasma by HPLC and DSPE

Two liquid chromatographic approaches for the simultaneous determination of xipamide and its degradation product (2,6‐xylidine) using time‐programmed fluorescence detection

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