Bioavailability properties of intravaginal implants made from chitosan-PEG-PCL in simulated vaginal fluid and vagina of cattle
Elma Yuliani Yessa,
Ietje Wientarsih,
Bambang Purwantara
et al.
Abstract:This study aimed to design and evaluate the bioavailability of intravaginal implants made from the biodegradable polymer chitosan-polyethylene glycol (PEG)-polycaprolactone (PCL) in simulated vaginal fluid (SVF) and the cow vagina. Implants were prepared using melt-ing and molding techniques with 26 different formulations. Next, the implants were immersed in 40 mL of SVF at a temperature of 37.8 ℃ and changes in implant morphology were observed every day until day 5. Implants that survived until day five were … Show more
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