Bioavailability, pharmacokinetics and tissue residues of cephradine (Atocef Forte®) in healthy and colisepticemic broiler chickens

Abstract

The pharmacokinetics (after single intravenous and oral dose) and tissue residues (orally and daily for five days) of cephradine (20 mg/kg b.wt.) were investigated in healthy and experimentally E.coli infected broiler chickens. Following single intravenous injection to healthy chickens, cephradine obeyed a two compartments open model and the elimination half-life (t1/2β), volume of distribution (Vdss) and total body clearance (CLtot) of cephradine were 2.93 h, 321.5 ml/kg and 0.08 L/h/kg, respectively. Following single oral administration of cephradine to healthy chickens, the peak serum concentration (Cmax) of it was 26.7 µg/mL and achieved (Tmax) at 2.41 h. The oral bioavailability of cephradine was 87.7%. Cephradine was assayed in kidney, liver, heart, gizzard, spleen, breast muscle, thigh muscle and skin after 24, 48, 72, 96 and 120 h after last dose. On conclusion, cephradine is a good choice for treatment of colisepticemia in chickens due to its higher oral bioavailability and distribution.

“Microbiological evaluation of antimicrobial agents potency in some Egyptian pharmaceutical products”

“…The 5 X 1 assay design was employed with cylinder plates containing antibiotic M11 agar medium and S. aureus ATCC 6538P (1ml containing around 10 8 CFU/ml per 100 ml of media). Aboubakr et al 18 , utilized the same assay design (5 X 1) in cylinder plates but containing Mueller-Hinton agar medium seeded with B. subtilis ATCC 6633 (160 µl of 10 8 CFU/ml per 100ml of media). These differences in the assay medium and sensitive microorganism indicates the need for the performance of several assay trials, with different microorganisms and microbiological media before starting the analysis, to apply the optimum conditions with suitable inhibition zone diameter.…”

Studies on the effects of cephradine and colibacellosis on immunological status of broiler chicken vaccinated with newcastle virus vaccine

“…and are based on 7-aminocephalosporic acid which crrosponds to 6-penicilanic acid in penicillins (El-Hewaity et al, 2014). Cephradinee is a beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity and available in both oral and parenteral dosage forms (Wilson and Gisvold, 1982).Cephradinee have a good activity against Gr +ve bacteria and moderate activity against some enterobacteria as strains of E coli, Proteus mirabilis, Salmonella and Shegella (James, 1993).Antibacterial activity due to ability of beta-lactamase ring to bind bacterial enzyme transpeptid-ase, which important for proper cell wall synthesis (Thomson et al, 1984;El Sayed et al, 2016;Aboubakr and Elbadawy, 2017). Escherichia coli, usually abbreviated to E.coli, is one of the main species of bacteria normally inhabitants lower intestines of wormblooded animals (birds and mammals) (Rosario et al, 2004).…”