Bioavailability of Quercetin from Onion Extracts after Intraruminal Application in Cows

Wein, Silvia; Beyer, Birgit; Zimmermann, Benno F.; Blank, Ralf; Wolffram, Siegfried

doi:10.1021/acs.jafc.8b03049

Cited by 10 publications

(5 citation statements)

References 35 publications

(73 reference statements)

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“…Several flavonoid metabolites were detected in human plasma, including tamarixetin, isorhamnetin, and kaempferol; however, their quantity is much lower than quercetin in plasma. In plasma, the major circulating metabolites of Q are conjugated with glucuronide, methyl, or sulfates, such as quercetin 3- O -β-D-glucuronide (Q3GA) and quercetin-3’-sulfate [ 44 ]. Thus, physiologically speaking, these phase-II metabolites, instead of R/Q, enter into the circulation system and exert their biological functions [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

Rutin and Quercetin Decrease Cholesterol in HepG2 Cells but Not Plasma Cholesterol in Hamsters by Oral Administration

Liang

et al. 2021

Molecules

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Rutin (R) and quercetin (Q) are two widespread dietary flavonoids. Previous studies regarding the plasma cholesterol-lowering activity of R and Q generated inconsistent results. The present study was therefore carried out to investigate the effects of R and Q on cholesterol metabolism in both HepG2 cells and hypercholesterolemia hamsters. Results from HepG2 cell experiments demonstrate that both R and Q decreased cholesterol at doses of 5 and 10 µM. R and Q up-regulated both the mRNA and protein expression of sterol regulatory element binding protein 2 (SREBP2), low-density lipoprotein receptor (LDLR), and liver X receptor alpha (LXRα). The immunofluorescence study revealed that R and Q increased the LDLR expression, while only Q improved LDL-C uptake in HepG2 cells. Results from hypercholesterolemia hamsters fed diets containing R (5.5 g/kg diet) and Q (2.5 g/kg diet) for 8 weeks demonstrate that both R and Q had no effect on plasma total cholesterol. In the liver, only Q reduced cholesterol significantly. The discrepancy between the in vitro and in vivo studies was probably due to a poor bioavailability of flavonoids in the intestine. It was therefore concluded that R and Q were effective in reducing cholesterol in HepG2 cells in vitro, whereas in vivo, the oral administration of the two flavonoids had little effect on plasma cholesterol in hamsters.

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Section: Discussionmentioning

confidence: 99%

Rutin and Quercetin Decrease Cholesterol in HepG2 Cells but Not Plasma Cholesterol in Hamsters by Oral Administration

Liang

et al. 2021

Molecules

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“…The estimation of relative bioavailability includes a comparison of two formulations or two routes of administration of the same formulation without involving intravenous administration. However, studies examining the relative bioavailability of flavonoids in general are more common [ 45 , 46 , 47 , 48 , 49 , 50 ].…”

Section: Bioavailability and Metabolism Of Quementioning

confidence: 99%

Quercetin and Its Nano-Formulations for Brain Tumor Therapy—Current Developments and Future Perspectives for Paediatric Studies

et al. 2023

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The development of efficient treatments for tumors affecting the central nervous system (CNS) remains an open challenge. Particularly, gliomas are the most malignant and lethal form of brain tumors in adults, causing death in patients just over 6 months after diagnosis without treatment. The current treatment protocol consists of surgery, followed using synthetic drugs and radiation. However, the efficacy of these protocols is associated with side effects, poor prognosis and with a median survival of fewer than two years. Recently, many studies were focused on applying plant-derived products to manage various diseases, including brain cancers. Quercetin is a bioactive compound derived from various fruits and vegetables (asparagus, apples, berries, cherries, onions and red leaf lettuce). Numerous in vivo and in vitro studies highlighted that quercetin through multitargeted molecular mechanisms (apoptosis, necrosis, anti-proliferative activity and suppression of tumor invasion and migration) effectively reduces the progression of tumor cells. This review aims to summarize current developments and recent advances of quercetin’s anticancer potential in brain tumors. Since all reported studies demonstrating the anti-cancer potential of quercetin were conducted using adult models, it is suggested to expand further research in the field of paediatrics. This could offer new perspectives on brain cancer treatment for paediatric patients.

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“…Studies have shown that ruminal microbes can break the b-glycosidic bond of rutin (quercetin3-O-rutinoside) leading to the release of quercetin and effectively enhancing its bioavailability in the gastrointestinal tract [125]. Furthermore, quercetin along with its methylated (isorhamnetin, tamarixetin) and dehydroxylated (kaempferol) derivatives have been detected in the systemic circulation of non-lactating cows [126], indicating a role of rumen microbes in flavonoid metabolism (Figure 3). Studies on the bioavailability of quercetin in ruminants are limited [96,125]; however, extensive reports are available in monogastric animals [7,127,128].…”

Section: Ruminal Degradation Absorption and Bioavailability Of Mulber...mentioning

confidence: 99%

“…Animals 2020, 10, x 8 of 24 along with its methylated (isorhamnetin, tamarixetin) and dehydroxylated (kaempferol) derivatives have been detected in the systemic circulation of non-lactating cows [126], indicating a role of rumen microbes in flavonoid metabolism (Figure 3). Studies on the bioavailability of quercetin in ruminants are limited [96,125]; however, extensive reports are available in monogastric animals [7,127,128].…”

Section: Ruminal Degradation Absorption and Bioavailability Of Mulber...mentioning

confidence: 99%

Potential of Mulberry Leaf Biomass and Its Flavonoids to Improve Production and Health in Ruminants: Mechanistic Insights and Prospects

Hassan

Arshad

et al. 2020

Animals

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Leaf biomass from the mulberry plant (genus Morus and family Moraceae) is considered a potential resource for livestock feeding. Mulberry leaves (MLs) contain high protein (14.0–34.2%) and metabolizable energy (1130–2240 kcal/kg) with high dry matter (DM) digestibility (75–85%) and palatability. Flavonoid contents of MLs confer unique antioxidant properties and can potentially help alleviate oxidative stress in animals during stressful periods, such as neonatal, weaning, and periparturient periods. In addition, mulberry leaf flavonoids (MLFs) possess antimicrobial properties and can effectively decrease the population of ruminal methanogens and protozoa to reduce enteric methane (CH4) production. Owing to its rich flavonoid content, feeding MLs increases fiber digestion and utilization leading to enhanced milk production in ruminants. Dietary supplementation with MLFs alters ruminal fermentation kinetics by increasing total volatile fatty acids, propionate, and ammonia concentrations. Furthermore, they can substantially increase the population of specific cellulolytic bacteria in the rumen. Owing to their structural homology with steroid hormones, the MLFs can potentially modulate different metabolic pathways particularly those linked with energy homeostasis. This review aims to highlight the potential of ML and its flavonoids to modulate the ruminal microbiome, fermentation, and metabolic status to enhance productive performance and health in ruminants while reducing CH4 emission.

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Bioavailability of Quercetin from Onion Extracts after Intraruminal Application in Cows

Cited by 10 publications

References 35 publications

Rutin and Quercetin Decrease Cholesterol in HepG2 Cells but Not Plasma Cholesterol in Hamsters by Oral Administration

Rutin and Quercetin Decrease Cholesterol in HepG2 Cells but Not Plasma Cholesterol in Hamsters by Oral Administration

Quercetin and Its Nano-Formulations for Brain Tumor Therapy—Current Developments and Future Perspectives for Paediatric Studies

Potential of Mulberry Leaf Biomass and Its Flavonoids to Improve Production and Health in Ruminants: Mechanistic Insights and Prospects

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