Bioavailability of oral dexamethasone

Duggan, D E; Yeh, Kuang C.; Matalia, N.; Ditzler, C. A.; McMahon, F. Gilbert

doi:10.1002/cpt1975182205

Cited by 99 publications

(47 citation statements)

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“…Possibly the use of direct gavage instead of mixture of test substances in the food, might slightly reduce the variability in dose exposure. Systemic exposure of CsA and DEX after oral administration is not confirmed in this study, but oral bioavailability has been shown for DEX [24] and for CsA [25] in humans and pigs respectively. The differences observed in CsA and DEX effects between the various species considered may not only be due to differences in dose and route of exposure, but may also be attributed to differences in the kinetics and metabolism of CsA and DEX in the different species compared.…”

Section: Discussioncontrasting

confidence: 63%

A Sub Acute Immunotoxicity Study in G?ttingen Minipigs? with the Immunosuppressive Compounds Cyclosporin A and Dexamethasone

2013

Clin Exp Pharmacol

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Introduction: There is a growing interest in the minipig as a non-rodent species in the safety assessment of (bio) pharmaceuticals and (agro) chemicals. For (bio) pharmaceuticals the need to evaluate the potential adverse effects on the immune system is an increasingly important aspect of safety evaluation. In the present study, cyclosporin A and Dexamethasone were used as model compounds to examine whether the regulatory endpoints requested for immunotoxicity testing can be tested in the Göttingen minipig.

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Section: Discussioncontrasting

confidence: 63%

A Sub Acute Immunotoxicity Study in G?ttingen Minipigs? with the Immunosuppressive Compounds Cyclosporin A and Dexamethasone

2013

Clin Exp Pharmacol

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“…Complex elimination kinetics of dexamethasone have previously been noted (Duggan et al, 1975). In the present study concurrent administration of cimetidine affected neither AUC nor serum concentrations of dexamethasone showing that there was no apparent effect of cimetidine on dexamethasone elimination.…”

Section: Resultssupporting

confidence: 41%

Cortisol and dexamethasone elimination during treatment with cimetidine.

Nr¹,

Rewhorn²,

Mc³

et al. 1984

Brit J Clinical Pharma

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“…day -1 is given intravenously or orally, plasma concentrations range 40±100 ng . mL -1 [26]. Hence, these in vivo concentrations are covered by the range of concentrations used in the present study.…”

Section: Discussionmentioning

confidence: 97%

Effects of theophylline, dexamethasone and salbutamol on cytokine gene expression in human peripheral blood CD4+ T-cells

Choy¹,

Ko²,

Li³

et al. 1999

Eur Respir J

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CD4+ T-cells are considered as pivotal in orchestrating the airway inflammation in asthma through the actions of their cytokines. Current hypothesis suggests that the anti-asthma effect of theophylline may be due to its anti-inflammatory actions, although the exact mechanisms remain unclear.The in vitro effect of theophylline on cytokine gene expression in peripheral blood CD4+ T-cells in normal subjects was compared with that of dexamethasone and salbutamol. CD4+ T-cells were cultured with phytohaemagglutin and phorbol myristate acetate in the presence of different concentrations of theophylline (10 -8 ±10 -3 M or 0.0018±180 mg . mL -1 ) in one group of subjects (n=8), dexamethasone (10 -9 ±10 -6 M or 0.39±390 ng . mL -1 ) in a second group (n=8) and salbutamol (10 -9 ±10 -4 M or 0.00058±58 mg . mL -1 ) in a third group (n=8). Gene expression of interleukin (IL)-3, IL-4, IL-5, granulocyte-macrophage colony-stimulating factor (GM-CSF) and interferon (IFN)-c was semiquantified by reverse transcription-polymerase chain reaction.Suppressed expression of IL-3 (36.9%), IL-4 (38.8%), GM-CSF (24.6%) and IFN-c (37.7%), but not of IL-5, was only seen with theophylline at a concentration of 10 -3 M (180 mg . mL -1 ) (p<0.05) and not at lower concentrations. In contrast, dexamethasone caused a dose-dependent suppression of transcription of all cytokines, with 39.5% for IL-3, 84.4% for IL-4, 40.6% for IL-5, 50.9% for GM-CSF and 31.8% for IFN-c at 10 -6 M (390 ng . mL -1 ) (p<0.05±0.001). Salbutamol did not suppress gene expression of any of the cytokines at the concentrations examined.These data suggest that cytokine gene expression of CD4+ T-cells is not affected at therapeutic concentrations of theophylline and salbutamol, but its suppression is likely to be an important mechanism underlying the therapeutic effect of corticosteroids in asthma.

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Bioavailability of oral dexamethasone

Cited by 99 publications

References 0 publications

A Sub Acute Immunotoxicity Study in G?ttingen Minipigs? with the Immunosuppressive Compounds Cyclosporin A and Dexamethasone

A Sub Acute Immunotoxicity Study in G?ttingen Minipigs? with the Immunosuppressive Compounds Cyclosporin A and Dexamethasone

Cortisol and dexamethasone elimination during treatment with cimetidine.

Effects of theophylline, dexamethasone and salbutamol on cytokine gene expression in human peripheral blood CD4+ T-cells

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