Bioavailability of natural and synthetic vitamins: A significant difference on Oxidative Stress Status (OSS)

Abstract

During the past few years, experiments have been in progress to study the bioavailability of vitamins and minerals provided by nature and chemistry. Vitamins and minerals extracted from plants associated with natural phytonutrients compounds was developed as supplement allowing better compatibility with human physiology. This Natural formula (Arkovital ® Pur'Energie) was studied by evaluating the antioxidant activities and comparing them to a formula which contain identical synthetic vitamins and minerals (Synthetic formula). Two clinical studies were conducted respectively on 6 (study 1) and 50 volunteers (study 2) with mean age 45 ± 7 years and 32 ± 12 years, respectively. Volunteers received, for 14 days, 2 pills of Arkovital ® Pur' Energie or 2 capsules of the synthetic formula. Efficacy was evaluated using the PAOT ® Skin Technology method (which measures the total antioxidant activity of supplements), classical analysis methods and electrochemical method (able to evaluate of skin oxidative stress status (SOSS) with PAOT Skin ® score). Measurements were taken on Day 0 and Day 15 on fasten volunteers. For the study 1, blood samples were taken from volunteers for monitoring of two oxidative stress biomarkers (vitamins C, E) and vitamin B6. The two studies demonstrate that natural vitamins and minerals contained in Arkovital ® Pur'Energie have a higher antioxidant power than synthetic vitamins and minerals. After 14 days of supplementation, the antioxidant status of people who received Arkovital ® Pur' Energie is increased significantly (p<0.05) by a factor of 2 compared to the synthetic formula. Oxidative stress biomarkers (vitamin C and E) monitoring in the study 1, did not shown a significant difference (p<0.05) between natural and synthetic formula which could be due to the small volunteers number in each group. The rate of B6 increased 6 times for volunteers who took Arkovital ® Pur'Energie and only by 4 times for those who took the synthetic supplement that after 14 days of supplementation.

Metabolites Alteration and Antioxidant Activity of Gracilaria verrucosa After Fermentation Using Aureobasidium melanogenum MTGK.31

“…Although our body is equipped with endogenous antioxidants, the utilization of exogenous antioxidants is recommended to act synergistically against free radicals (Martemucci et al, 2022). However, exogenous antioxidants are dominated by synthetic drugs and vitamins that caused toxicity and carcinogenicity (Kornienko et al, 2019;Meziane et al, 2021;Rutkowski & Grzegorczyk, 2012). Hence, it is suggested to utilize the dietary antioxidants present in food since they are safe and contain rich nutritional and therapeutic effects (Aryal et al, 2019;Lourenço et al, 2019).…”