Bioavailability of glycitein relatively to other soy isoflavones in healthy young Caucasian men

Shinkaruk, Svitlana; Durand, M.; Lamothe, Valérie; Carpaye, Allison; Martinet, Amandine; Chantre, P.; Vergne, Sébastien; Nogués, Xavier; Moore, Nicholas; Bennetau-Pelissero, Catherine

doi:10.1016/j.foodchem.2012.03.135

Cited by 23 publications

(18 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Maximum serum concentration for glycitein attained after ingestion of aglycone and glucosidic forms of soy beverage did not differ significantly (0.07–0.09 μmol/L), and maximum urinary excretion was reported to be ~ 3 μmol [ 59 ]. Similarly, maximum glycitein plasma concentration of ~ 200 ng/ml and maximum glycitein urinary concentration of 11,000 ng/ml were reported in a bioavailability study [ 60 ]. A large soy intervention trial demonstrated a three- to fourfold increase in glycitein levels in plasma, overnight urine, and spot urine was observed in the soy group compared to the placebo.…”

Section: Resultsmentioning

confidence: 61%

Biomarkers of legume intake in human intervention and observational studies: a systematic review

et al. 2018

View full text Add to dashboard Cite

There is a growing interest in assessing dietary intake more accurately across different population groups, and biomarkers have emerged as a complementary tool to replace traditional dietary assessment methods. The purpose of this study was to conduct a systematic review of the literature available and evaluate the applicability and validity of biomarkers of legume intake reported across various observational and intervention studies. A systematic search in PubMed, Scopus, and ISI Web of Knowledge identified 44 studies which met the inclusion criteria for the review. Results from observational studies focused on soy or soy-based foods and demonstrated positive correlations between soy intake and urinary, plasma or serum isoflavonoid levels in different population groups. Similarly, intervention studies demonstrated increased genistein and daidzein levels in urine and plasma following soy intake. Both genistein and daidzein exhibited dose-response relationships. Other isoflavonoid levels such as O-desmethylangolensin (O-DMA) and equol were also reported to increase following soy consumption. Using a developed scoring system, genistein and daidzein can be considered as promising candidate markers for soy consumption. Furthermore, genistein and daidzein also served as good estimates of soy intake as evidenced from long-term exposure studies marking their status as validated biomarkers. On the contrary, only few studies indicated proposed biomarkers for pulses intake, with pipecolic acid and S-methylcysteine reported as markers reflecting dry bean consumption, unsaturated aliphatic, hydroxyl-dicarboxylic acid related to green beans intake and trigonelline reported as marker of peas consumption. However, data regarding criteria such as specificity, dose-response and time-response relationship, reliability, and feasibility to evaluate the validity of these markers is lacking. In conclusion, despite many studies suggesting proposed biomarkers for soy, there is a lack of information on markers of other different subtypes of legumes. Further discovery and validation studies are needed in order to identify reliable biomarkers of legume intake.Electronic supplementary materialThe online version of this article (10.1186/s12263-018-0614-6) contains supplementary material, which is available to authorized users.

show abstract

Section: Resultsmentioning

confidence: 61%

Biomarkers of legume intake in human intervention and observational studies: a systematic review

et al. 2018

View full text Add to dashboard Cite

show abstract

“…However, transport across the monolayer was greater with shorter molecules. The in vivo human study carried out by Shinkaruk and others () revealed that the bioavailability of glycitein from soy‐based food was similar to that of daidzein and its urinary excretion was significantly higher than that of genistein.…”

Section: Approaches In the Assessment Of Bioaccessibility And Bioavaimentioning

confidence: 96%

Analytical Methods for Determining Bioavailability and Bioaccessibility of Bioactive Compounds from Fruits and Vegetables: A Review

Carbonell-Capella

Buniowska

Barba

et al. 2014

Comp Rev Food Sci Food Safe

533

337

View full text Add to dashboard Cite

Determination of bioactive compounds content directly from foodstuff is not enough for the prediction of potential in vivo effects, as metabolites reaching the blood system may be different from the original compounds found in food, as a result of an intensive metabolism that takes place during absorption. Nutritional efficacy of food products may be ensured by the determination of bioaccessibility, which provides valuable information in order to select the appropriate dosage and source of food matrices. However, between all the methods available, there is a need to establish the best approach for the assessment of specific compounds. Comparison between in vivo and in vitro procedures used to determine bioaccessibility and bioavailability is carried out, taking into account the strengths and limitations of each experimental technique, along with an intensive description of actual approaches applied to assess bioaccessibility of bioactive compounds. Applications of these methods for specific bioactive compound's bioaccessibility or bioavailability are also discussed, considering studies regarding the bioavailability of carotenoids, polyphenolic compounds, glucosinolates, vitamin E, and phytosterols.

show abstract

“…Notably, of the adult population only 25–30% in western countries, but 50–60% in Asian countries, harbor the required colonic bacteria and are thus equol producers (6–8). After the intake of soy-based formulations, maximum plasma concentrations of equol occurred after ~16 h at around 130 ng/ml (~0.5 µM) (9,10). S-(−) equol shows both estrogenic properties as a selective estrogen-receptor β modulator and antiproliferative effects on prostatic epithelial cells (7,11).…”

Section: Introductionmentioning

confidence: 99%

Urolithin A gains in antiproliferative capacity by reducing the glycolytic potential via the p53/TIGAR axis in colon cancer cells

Norden

Heiß

2018

Carcinogenesis

View full text Add to dashboard Cite

show abstract

Bioavailability of glycitein relatively to other soy isoflavones in healthy young Caucasian men

Cited by 23 publications

References 32 publications

Biomarkers of legume intake in human intervention and observational studies: a systematic review

Biomarkers of legume intake in human intervention and observational studies: a systematic review

Analytical Methods for Determining Bioavailability and Bioaccessibility of Bioactive Compounds from Fruits and Vegetables: A Review

Urolithin A gains in antiproliferative capacity by reducing the glycolytic potential via the p53/TIGAR axis in colon cancer cells

Contact Info

Product

Resources

About