Bioavailability of dietary polyphenols: Factors contributing to their clinical application in CNS diseases

Pandareesh, M. D.; Mythri, Rajeswara Babu; Bharath, M. M. Srinivas

doi:10.1016/j.neuint.2015.07.003

Cited by 108 publications

(73 citation statements)

References 186 publications

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“…For example, poor bioavailability of curcumin (1%) [270], resveratrol (1%) [271, 272] and EGCG (0.1%) [273] has been a major obstacle in the in drug development relating to these agents. This will also have a significant bearing on the concentration of these agents in the brain after transporting through the blood brain barrier (BBB) [274, 275]. Improvement bioavailability of polyphenols using different delivery systems is a major area of current research [276].…”

Section: Summary and Future Perspectivesmentioning

confidence: 99%

Polyphenol compounds and PKC signaling

Das

Ramani

Suraju

2016

Biochimica et Biophysica Acta (BBA) - General Subjects

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Background Naturally occurring polyphenols found in food sources provide huge health benefits. Several polyphenolic compounds are implicated in the prevention of disease states, such as cancer. One of the mechanisms by which polyphenols exert their biological actions is by interfering in the protein kinase C (PKC) signaling pathways. PKC belongs to a superfamily of serine-threonine kinase and are primarily involved in phosphorylation of target proteins controlling activation and inhibition of many cellular processes directly or indirectly. Scope of review Despite the availability of substantial literature data on polyphenols' regulation of PKC, no comprehensive review article is currently available on this subject. This article reviews PKC-polyphenol interactions and its relevance to various disease states. In particular, salient features of polyphenols, PKC, interactions of naturally occurring polyphenols with PKC, and future perspective of research on this subject are discussed. Major conclusions Some polyphenols exert their antioxidant properties by regulating the transcription of the antioxidant enzyme genes through PKC signaling. Regulation of PKC by polyphenols is isoform dependent. The activation or inhibition of PKC by polyphenols has been found to be dependent on the presence of membrane, Ca2+ ion, cofactors, cell and tissue types etc. Two polyphenols, curcumin and resveratrol are in clinical trials for the treatment of colon cancer. General significance The fact that 74% of the cancer drugs are derived from natural sources, naturally occurring polyphenols or its simple analogs with improved bioavailability may have the potential to be cancer drugs in the future.

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Section: Summary and Future Perspectivesmentioning

confidence: 99%

Polyphenol compounds and PKC signaling

Das

Ramani

Suraju

2016

Biochimica et Biophysica Acta (BBA) - General Subjects

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“…Potential difficulties in performing water volumetry are described in [39]. Finally, considering limited bioavailability and rapid metabolism of some dietary polyphenols [5,40,41], further research and review of pharmacokinetics of different Fls is needed.…”

Section: If Vasoconstriction Is Indeed Favorable In Venousmentioning

confidence: 99%

The potential use of flavonoids as venoactive drugs and the role of citrus fruits

Jargin¹

2018

J Intercult Ethnopharmacol

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“…Once absorbed, the aglycones are subjected to conjugation such as methylation, sulfation, and glucuronidation, that increase their hydrophilicity for biliary and urinary elimination. Both the aglycones and the conjugated forms can pass the BBB to access the CNS(Jäger and Saaby, 2011;Pandareesh, Mythri, & Bharath, 2015). However, the bioavailability of polyphenols is extensively variable between individuals(Pandareesh et al, 2015).…”

mentioning

confidence: 99%

“…Both the aglycones and the conjugated forms can pass the BBB to access the CNS(Jäger and Saaby, 2011;Pandareesh, Mythri, & Bharath, 2015). However, the bioavailability of polyphenols is extensively variable between individuals(Pandareesh et al, 2015). In 2003, Youdim et al demonstrated that dietary polyphenols and their metabolites were taken up in dose-and time-dependent manner.…”

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confidence: 99%

Neuritogenic and neuroprotective constituents fromAquilaria crassnaleaves

Supasuteekul

Tadtong

Putalun

et al. 2017

Journal of Food Biochemistry

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The leaves of Aquilaria crassna (Thymelaeaceae) are recently become an attractive research due to their potential in antioxidative, antibacterial, antipyretic, analgesic, and laxative activities. However, the neuritogenic and neuroprotective effects of A. crassna leaves have never been reported. In this study, three phenolic glycosides were isolated from A. crassna leaves. The isolates were identified as genkwanin 5‐O‐β‐primevoside (1), iriflophenone 3,5‐C‐β‐d‐diglucoside (2) and iriflophenone 3‐C‐β‐d‐glucoside (3). The neuroprotective and neuritogenic activities of these compounds were evaluated. Compound 1 and 2, at very low concentration (100 ng/mL of compound 1 and 1 ng/mL of compound 2), exhibited the protection of P19‐derived neurons and promoted the neurite outgrowth of the cultured neurons. In addition, a preliminary study on these compounds revealed that there was no correlation between their antioxidative properties and their neuroprotective activities. Practical applications Agarwood leaves have been used as an ingredient in foods and drinks for health promotion in Asian countries. The results of this study also suggest that Aquilaria crassna leaves are potentially sources of neuritogenic and neuroprotective constituents, which may be developed as functional foods for the prevention of neurodegenerative disorder.

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Bioavailability of dietary polyphenols: Factors contributing to their clinical application in CNS diseases

Cited by 108 publications

References 186 publications

Polyphenol compounds and PKC signaling

Polyphenol compounds and PKC signaling

The potential use of flavonoids as venoactive drugs and the role of citrus fruits

Neuritogenic and neuroprotective constituents fromAquilaria crassnaleaves

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