Bioavailability of cranberry bean hydroalcoholic extract and its inhibitory effect against starch hydrolysis following in vitro gastrointestinal digestion

Chiang, Yi Chen; Chen, Chung Li; Jeng, Toong Long; Lin, Tzu Che; Sung, Jih Min

doi:10.1016/j.foodres.2014.08.049

Cited by 24 publications

(20 citation statements)

References 29 publications

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“…We found that the OUT samples, representing the “colon-available” fractions, showed higher values of TPC, Flavo and ACY, compared to the IN samples, and among the different types of berries blackcurrant presented the highest content of TPC, Flavo and ACY; the lowest values were registered for blueberry (TPC and ACY) and raspberry (Flavo). Our results are in agreement with those previously reported that highlighted a remarkable reduction of polyphenols in the IN fraction, compared to the OUT samples, in different berries, as for anthocyanins in strawberry and red wine [ 24 , 28 ], for total polyphenols and anthocyanins in wild blueberries and chockberry juice [ 25 , 26 ], for total polyphenols in cranberry bean extract and blackberry [ 27 , 30 ].…”

Section: Discussionsupporting

confidence: 93%

“…Consequently, some functional nutrients and phytochemicals are transformed into other compounds with varied bioactivity [ 23 ]. Although some studies have evaluated the composition and the functional activities of some berries after the in vitro GI digestion process, it is necessary to deepen our knowledge on their bioacessability in order to underline the real effect of berry consumption on human health [ 24 , 25 , 26 , 27 , 28 , 29 , 30 ]. In the last few years, in vitro digestion methods for simulating the GI conditions have been broadly employed, since they are faster and cheaper than the in vivo analyses on animal or humans [ 16 , 31 ].…”

Section: Discussionmentioning

confidence: 99%

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Phytochemical Composition and Cytotoxic Effects on Liver Hepatocellular Carcinoma Cells of Different Berries Following a Simulated In Vitro Gastrointestinal Digestion

et al. 2018

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Berry fruits are rich in nutrients and polyphenols, providing potential health benefits. Understanding the factors that affect their bioavailability is becoming of utmost importance for evaluating their biological significance and efficacy as functional food. In this study, the phytochemical composition and the total antioxidant capacity of different varieties of five berries (blackberry, blackcurrant, blueberry, raspberry, and strawberry) were evaluated after an in vitro gastrointestinal digestion process. The cultivar of each berry that showed the higher content of total phenols and flavonoids was selected to study its cytotoxic effect on human hepatoma cells. Digestion resulted in a high reduction (p ˂ 0.05) of total phenolic, flavonoid and anthocyanin contents and total antioxidant capacity, in the “IN” samples compared to the “OUT” extracts, which represent the “serum-available” and the “colon-available” fractions, respectively. Incubation of the digested fraction for 24 h didn’t exert any effect on cellular viability, while a dose- and time-dependent cytotoxicity was observed after 48 h and 72 h of incubation for all the berries analyzed. Our results suggest that the approach proposed in this work may represent a rapid tool for evaluating and identifying new berries with increased phytochemical bioavailability, highlighting their antiproliferative agents after an in vitro digestion.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Phytochemical Composition and Cytotoxic Effects on Liver Hepatocellular Carcinoma Cells of Different Berries Following a Simulated In Vitro Gastrointestinal Digestion

et al. 2018

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“…In the colon phase the results were quite similar to those obtained in the duodenal phase (as evident in Table 3), and for this reason the chromatograms of the colon step were not reported in Figures 7 and 8. The above described results agreed with data reported by Chang et al [60] and by Tavares et al [61], who assessed the bioaccessibility of cranberry bean and blackberry polyphenols, respectively. In fact, both these works reported an increase in the concentration of the polyphenolic compounds after the gastric phase and a subsequent strong reduction at the end of the intestinal phase, probably due to the interactions of polyphenols with proteins, generally occurring at neutral or basic pH [60].…”

Section: Bioaccessibility Studysupporting

confidence: 92%

“…The above described results agreed with data reported by Chang et al [60] and by Tavares et al [61], who assessed the bioaccessibility of cranberry bean and blackberry polyphenols, respectively. In fact, both these works reported an increase in the concentration of the polyphenolic compounds after the gastric phase and a subsequent strong reduction at the end of the intestinal phase, probably due to the interactions of polyphenols with proteins, generally occurring at neutral or basic pH [60]. profile were registered after the duodenal step (Figures 7 and 8) for all the peak markers; in particular, the peak area of each anthocyanin was approximately zero, confirming their high instability at basic pH [57,59].…”

Section: Bioaccessibility Studysupporting

confidence: 92%

A New Italian Purple Corn Variety (Moradyn) Byproduct Extract: Antiglycative and Hypoglycemic In Vitro Activities and Preliminary Bioaccessibility Studies

et al. 2020

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The reuse of byproducts from agricultural and food industries represents the key factor in a circular economy, whose interest has grown in the last two decades. Thus, the extraction of bioactives from agro-industrial byproducts is a potential source of valuable molecules. The aim of this work was to investigate the in vitro capacity of byproducts from a new Italian corn variety, named Moradyn, to inhibit the accumulation of advanced glycation end products (AGEs) involved in several chronic age-related disorders. In addition, the hypoglycemic effect of Moradyn was tested by in vitro enzymatic systems. A Moradyn phytocomplex and its purified anthocyanin fraction were able to inhibit fructosamine formation and exhibited antiglycative properties when tested using BSA-sugars and BSA-methylglyoxal assays. These properties could be attributed to the polyphenols, mainly anthocyanins and flavonols, detected by RP-HPLC-DAD-ESI-MS n . Finally, a Moradyn phytocomplex was submitted to a simulated in vitro digestion process to study its bioaccessibility. Moradyn could be considered as a promising food ingredient in the context of typical type 2 diabetes risk factors and the study will continue in the optimization of the ideal formulation to preserve its bioactivities from digestion. Molecules 2020, 25, 1958 2 of 21 pelargonidin-3,5-di-O-glucoside [3]; cyanidin-, peonidin-, and perlargonidin-3-O-di-malonylglucoside [9], cyanidin-3-O-succinylglucoside, cyanidin-3-O-malonylglucoside-5-O-glucoside [5], and cyanidin-3,5di-O-glucoside, this one identified for the first time in purple corn by Žilić et al. [10]. Moreover, several authors have detected ethyl-malonylated anthocyanins that probably originate during the extraction process, and which are known to stabilize pigments, thus prolonging shelf life [5,8].Husk and cob extracts are richer in anthocyanins than kernel extracts, ranging from 0.49% to 4.6% (dry weight) for cobs [1,5]; moreover, husks and cobs differ from kernels for the presence of perlagonidin in their phytocomplex [3].Nowadays, several food byproducts such as olive leaves and oil mill wastewater, grape skin, fruit and vegetable seeds, and artichoke bracts and stems have been deeply investigated for their important role in the inhibition of advanced glycation end products (AGEs) formation [11][12][13][14][15]. AGEs are typical adducts derived from Maillard reaction or non-enzymatic glycation process. These compounds are involved in many chronic diseases, such as cardiovascular pathologies, type 2 diabetes, and neurodegenerative disorders, and their formation increases in association with hyperglycemia and metabolic dysfunctions [16][17][18][19]. Thanks to their high polyphenol content, purple corn byproducts have been associated with several health properties such as antioxidant, anti-inflammatory, and antiglycative activity [2,10,[20][21][22][23]. Moreover, in vitro and in vivo studies demonstrate their capacity in the prevention of cardiovascular and type 2 diabetes risk factors by exerting a strong anti-hypertensi...

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“…After gastric and intestinal digestion, it increased to 6.81 ± 0.22, and 10.38 ± 1.34 mg/ml with a final increase of 3.6 times, respectively. This indicated that gastrointestinal digestion negatively affected the α-glucosidase inhibition of PFLE, which was consistent with the previous reports that gastrointestinal digestion reduced α-glucosidase inhibitory ability of samples (Burgos-Edwards et al, 2017;Chiang et al, 2014;Li et al, 2015). In addition, the α-glucosidase inhibitory activity of all samples was significantly lower than that of the control acarbose (0.49 ± 0.10 mg/ml), the reason for this may be that these samples were complex mixtures and the active compounds with α-glucosidase inhibitory ability were only a small fraction of the total mixture.…”

Section: F I G U R Esupporting

confidence: 92%

The influence of in vitro gastrointestinal digestion on the Perilla frutescens leaf extract: Changes in the active compounds and bioactivities

Wang

et al. 2020

J. Food Biochem.

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In this study, the influence of in vitro gastrointestinal digestion on the Perilla frutescens leaf extract (PFLE) were measured. Results revealed that total phenolic content (TPC) and total flavonoid content (TFC) were significantly decreased after simulated digestion (ca. 53% of phenolics and 40% of flavonoids). The IC 50 value of DPPH• scavenging activity and ABTS + scavenging ability increased by 23% and 56%, respectively, while ferric reducing antioxidant power reduced by 53%. For the inhibition ability on α-glucosidase, acetylcholinesterase, and MCF-7 cell proliferation, their IC 50 values increased by 360%, 197%, and 25%, respectively. Three phenolic acids and one flavonoid in PFLE were quantified by high-performance liquid chromatography. Overall, although significant losses of the active components and biological activities occurred during in vitro gastrointestinal digestion, it still showed the potential as an oral agent for treatment and prevention of oxidative stress, cancer, diabetes, and Alzheimer's disease. Practical applications As an important annual herbaceous plant with rich biochemical compounds and many biological functions, Perilla frutescens leave is widely used in the food and traditional Chinese medicine. However, the dynamic changes of its active compounds and activities during the digestion process are unclear. In this study, the digestion results in significant loss of the active ingredients and biological activities of P. frutescens leaf extract (PFLE), particularly in the gastric digestion. In addition, PFLE remains to show certain antioxidant activity, α-glucosidase inhibitory ability, acetylcholinesterase inhibitory ability, and MCF-7 cell proliferation inhibitory ability after digestion.

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Bioavailability of cranberry bean hydroalcoholic extract and its inhibitory effect against starch hydrolysis following in vitro gastrointestinal digestion

Cited by 24 publications

References 29 publications

Phytochemical Composition and Cytotoxic Effects on Liver Hepatocellular Carcinoma Cells of Different Berries Following a Simulated In Vitro Gastrointestinal Digestion

Phytochemical Composition and Cytotoxic Effects on Liver Hepatocellular Carcinoma Cells of Different Berries Following a Simulated In Vitro Gastrointestinal Digestion

A New Italian Purple Corn Variety (Moradyn) Byproduct Extract: Antiglycative and Hypoglycemic In Vitro Activities and Preliminary Bioaccessibility Studies

The influence of in vitro gastrointestinal digestion on the Perilla frutescens leaf extract: Changes in the active compounds and bioactivities

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