Bioavailability of Acetazolamide Tablets

Pharmacokinetics of acetazolamide after intravenous and oral administration in horses

“…Peak plasma concentration after oral administration of acetazolamide in humans is achieved within 60 to 120 minutes. 27,28 This value is comparable with the mean value observed in the horses of our study (T MAX = 1.61 ± 1.24 hours). The median Vd ss of 433 ± 218 ml/kg indicated drug distribution that exceeded extracellular fluid volume and approached that of total body water.…”

Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Acetazolamide

“…Yakatan et al 41 evaluated the BA of five different lots of 250 mg acetazolamide tablets from a single manufacturer in 20 healthy volunteers. The composition of the tablets was not reported.…”

“…22 Yakatan et al 41 reported that the observed differences in C max for five 250-mg acetazolamide tablets showed general trends for correlation with in vitro USP XIX dissolution tests, using stirring speeds at 50 and 100 rpm, in gastric fluid without pepsin and carbonate buffer pH 10, although the observed differences between the tablets did not appear to be of a sufficient magnitude to make the dissolution tests discriminatory except for one tablet, which proved to be the lowest disintegrating form tested. A better in vivo/in vitro correlation (IVIVC) was obtained with a rotatingfilter-stationary basket apparatus.…”

Relative bioavailability of acetazolamide tablets

“…In another study, Yakatan et a1. 2 evaluated the performance of five lots of acetazolamide 250 mg tablets from the same manufacturer, using a balanced incomplete block design and 20 subjects. They found differences among lots in terms of maximum acetazolamide plasma concentrations in humans given the drug.…”