Bioavailability of 2,3′,4,4′,5-pentachlorobiphenyl (PCB118) and 2,2′,5,5′-tetrachlorobiphenyl (PCB52) from soils using a rat model and a physiologically based extraction test

Pu, Xinzhu; Lee, Linda; Galinsky, Raymond E.; Carlson, Gary P.

doi:10.1016/j.tox.2005.08.012

Cited by 34 publications

(32 citation statements)

References 31 publications

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“…This resulted in less fecal elimination of radioactivity in the aged sediments containing low black carbon (SS and SS ϩ CL) than the aged sediments containing high black carbon contents (SS ϩ ST and SS ϩ CL ϩ ST). Similar results have been reported by Pu et al [11,18] after oral gavage administration of phenanthrene and two polychlorinated biphenyl congeners to rats. Impact of clay on reduction of oral bioavailability of soiladsorbed chemicals is likely due to the high surface area of clay enhancing sorption through weak physical interactions and impeding chemical mass transfer due to aggregation and clay interlayers [34].…”

Section: Discussionsupporting

confidence: 90%

Effect of organic carbon content, clay type, and aging on the oral bioavailability of hexachlorobenzene in rats

Saghir

Bartels

Budinsky

et al. 2007

Enviro Toxic and Chemistry

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Bioavailability of lipophilic chemicals is influenced by the physicochemical properties of soils/sediment such as particle size, pH, clay, and organic carbon content. The present study investigated the effects of sediment composition and aging on the oral bioavailability of hexachlorobenzene (HCB) in rats. Formulated sediments were prepared using various ratios of kaolinite and montmorillonite clay, sand, peat moss, and black carbon, spiked with (14)C-HCB, and orally administered to rats prior to and after one year of aging in dark at 10 degrees C. In the nonaged sediments there was a 21 to 45% reduction in the oral bioavailability of HCB when compared to the corn oil standard without any clear pattern of the impact of the sediment clay and/or organic carbon content. One year of aging resulted in statistically significant (p = 0.049) reduction in the oral bioavailability of HCB from the sediments compared to the corn oil standard and nonaged sediment indicating stronger interactions between HCB and sediment contents with aging. The mean reduction in oral bioavailability after one year of aging ranged from approximately 5 to 14% greater than that observed for nonaged sediments. The fecal elimination of the HCB-derived radioactivity from the one-year-aged sediments was much higher than the nonaged sediments, consistent with the lower absorption from the gastrointestinal tract due to lower desorption of HCB from the aged sediments. Increase in the fecal elimination and decrease in oral bioavailability of (14)C-HCB was related to the increase in clay and black carbon.

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Section: Discussionsupporting

confidence: 90%

Effect of organic carbon content, clay type, and aging on the oral bioavailability of hexachlorobenzene in rats

Saghir

Bartels

Budinsky

et al. 2007

Enviro Toxic and Chemistry

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“…The relative bioavailability of PCBs (101, 138, 153 and 180) in soil was assessed by measuring concentrations found in swines' adipose tissue: values were all greater than 45%, independently of the investigated soil or PCB congener [67]. For PCBs 52 and 118 in soil, the relative bioavailability measured in rats' blood was greater than 87% and could not be linked to their bioaccessibility measured by PBET, which produced underestimated results (40% to 80%) [68]. An in vivo/in vitro validation study was also undertaken for PFOA in food, and showed a good correlation (r=0.76, p<0.01) between PFOA bioaccessibility, assessed with the UBM method, and its bioavailability measured in rats' liver [70].…”

Section: Specific Human Populations Models Used For the Analysis Of mentioning

confidence: 99%

Oral bioaccessibility of semi-volatile organic compounds (SVOCs) in settled dust: A review of measurement methods, data and influencing factors

Raffy

Mercier

Glorennec

et al. 2018

Journal of Hazardous Materials

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Many semi-volatile organic compounds (SVOCs), suspected of reprotoxic, neurotoxic or carcinogenic effects, were measured in indoor settled dust. Dust ingestion is a non-negligible pathway of exposure to some of these SVOCs, and an accurate knowledge of the real exposure is necessary for a better evaluation of health risks. To this end, the bioaccessibility of SVOCs in dust needs to be considered. In the present work, bioaccessibility measurement methods, SVOCs' oral bioaccessibility data and influencing factors were reviewed. SVOC bioaccessibilities (%) ranged from 11 to 94, 8 to 100, 3 to 92, 1 to 81, 6 to 52, and 2 to 17, for brominated flame retardants, organophosphorus flame retardants, polychlorobiphenyls, phthalates, pesticides and polycyclic aromatic hydrocarbons, respectively. Measurements method produced varying results depending on the inclusion of food and/or sink in the model. Characteristics of dust, e.g., organic matter content and particle size, also influenced bioaccessibility data. Last, results were influenced by SVOC properties, such as octanol/water partition coefficient and migration pathway into dust. Factors related to dust and SVOCs could be used in prediction models. To this end, more bioaccessibility studies covering more substances should be performed, using methods that are harmonized and validated by comparison to in-vivo studies.

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“…In terrestrial animals, the relative bioavailability of hydrophobic organic compounds bound to soil seems to depend on the animal species. In rats, no decrease in PCB bioavailability was detected, whatever the organic carbon content (0.5%–2.9%) of the ingested soils . In hens, no decrease in PCB bioavailability was observed between contaminated soil (1.2% organic matter) and oil .…”

Section: Resultsmentioning

confidence: 86%

Bioavailability and bioaccumulation of sediment‐bound polychlorinated biphenyls to carp

Gaillard

Banas

Thomas

et al. 2014

Enviro Toxic and Chemistry

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The relative bioavailability of sediment-bound polychlorinated biphenyls (PCBs 138, 153, and 180) from a local contaminated site was examined using an in vivo carp model. Surface sediment from the PCB-contaminated site and spiked canola oil containing equivalent masses of PCBs were respectively incorporated in the sediment-dosed diets and oil-dosed diets at 3 dose levels resulting in 6 experimental diets. Juvenile carps (n = 90) were divided in 18 tanks (5 fish × 6 treatments × 3 tanks). Fish were fed the control diet during the adaptation period (15 d). Next, 1 fish was sampled in each tank and muscle tissues were combined in control groups. During the exposure period (15 d), the remaining fish were fed with 1 of the 6 experimental diets. At the end of the experiment, fish were sampled and muscle tissues were combined for each tank. The PCBs were monitored in feed and fish muscle. For both the contaminated sediment and spiked canola oil groups, concentrations of PCBs 138, 153, and 180 in muscle linearly increased with concentrations in food, with similar intercepts and slopes. In the present study, the sediment-bound PCBs were as bioavailable as those spiked into canola oil and fed to carp in a standard diet.

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Bioavailability of 2,3′,4,4′,5-pentachlorobiphenyl (PCB118) and 2,2′,5,5′-tetrachlorobiphenyl (PCB52) from soils using a rat model and a physiologically based extraction test

Cited by 34 publications

References 31 publications

Effect of organic carbon content, clay type, and aging on the oral bioavailability of hexachlorobenzene in rats

Effect of organic carbon content, clay type, and aging on the oral bioavailability of hexachlorobenzene in rats

Oral bioaccessibility of semi-volatile organic compounds (SVOCs) in settled dust: A review of measurement methods, data and influencing factors

Bioavailability and bioaccumulation of sediment‐bound polychlorinated biphenyls to carp

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