Bioavailability, metabolism and physiological impact of 4-oxo-flavonoids

Manach, Claudine; Regerat, F; Texier, Odile; Agullo, Georgine; Demigné, Christian; Rémésy, Christian

doi:10.1016/0271-5317(96)00032-2

Cited by 204 publications

(116 citation statements)

References 131 publications

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“…Herbs that are rich in flavonoids such as thyme (Thymus vulgaris) extend the activity of vitamin C, act as antioxidants and may therefore enhance the immune function (Manach et al, 1996;Cook and Samman, 1996). In the present study, dietary treatments failed to have any significant (P>0.05) influence on antibody response to SRBC (Table 3).…”

Section: Effect Of Feed Supplements On Broilermentioning

confidence: 48%

Effects of Ground Thyme and Probiotic Supplements in Diets on Broiler Performance, Blood Biochemistry and Immunological Response to Sheep Red Blood Cells

Hosseini

Meimandipour

Alami

et al. 2013

Italian Journal of Animal Science

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A trial was conducted to study the effects of the aromatic plant thyme, a commercial probiotic (Protexin) and avilamycin on broiler performance, blood biochemical parameters and also the antibody response to sheep red blood cells. A total of 750 broilers were assigned into five replicate groups for each of five dietary treatments, namely; control (C), 2.5 mg/kg avilamycin (AB), 0.1 g/kg commercial probiotic (P), 5 g/kg ground thyme (T1), and 7.5 g/kg ground thyme (T2). In general, body weight, feed consumption and feed conversion ratio were not affected by dietary treatments compared to the control birds (P>0.05). Birds fed the P supplemented treatment had the greatest serum protein levels (P<0.001) and highest albumin levels (P<0.001) when compared with control birds, while the birds fed T2 had the lowest (P<0.001). Dietary supplementation reduced (P<0.001) cholesterol and triglyceride concentration in serum of broilers, with the effect were more noticeable by P supplements. Moreover, blood calcium and phosphorus concentrations were higher (P<0.001) in birds fed the P-supplemented diet compared to the birds fed the control diets.This study suggests that probiotic supplementation in particular, and to an intermediate extent ground thyme supplementation in diets of broiler, resulted in chicks with favorably improved blood biochemical parameters and mineral utilization, compared to the birds fed diets supplemented with avilamycin or without any supplementation.

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Section: Effect Of Feed Supplements On Broilermentioning

confidence: 48%

Effects of Ground Thyme and Probiotic Supplements in Diets on Broiler Performance, Blood Biochemistry and Immunological Response to Sheep Red Blood Cells

Hosseini

Meimandipour

Alami

et al. 2013

Italian Journal of Animal Science

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“…They occur in fruits, vegetables, nuts, seeds, stems, and flowers as well as tea, wine, propolis, and honey. Flavonoids exhibit a broad spectrum of biological activities: cardiovascular protection [1], antioxidant [2], anticancer [3], antiviral [4], anti-inflammatory, and antimicrobial activity [5]. They have played major roles in successful medical treatments in ancient as well as modern times [6].…”

Section: Introductionmentioning

confidence: 99%

New sulfonic derivatives of quercetin as complexing reagents: synthesis, spectral, and thermal characterization

Woźnicka

Pieniążek

Zapała

et al. 2014

J Therm Anal Calorim

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The synthesis conditions of quercetin-8-sulfonic acid and sodium salt of sulfonated quercetin were determined. The molecular formulae of obtained compounds are: C 15 H 10 O 10 SÁ4H 2 O and C 15 H 9 O 10 SNaÁ4H 2 O. On the basis of spectral methods UV-Vis, IR, and 1 H NMR it was stated that the sulfonation of quercetin occurs at 8-C position of the A ring. The complexing properties of Na-QSA-8 were confirmed by synthesis of a solid complex with Fe(II) ions. The NaQSA-8 formed a complex with Fe(II) ions at pH 5 with the metal excess (c M :c L = 7:1). The chelation site was analyzed using spectroscopy methods. It was found that chelation of the metal ions occurs at the 4C=O, 3-OH and 3 0 -OH, and 4 0 -OH sites of the molecule NaQSA-8. Thermal decomposition of the compounds was carried out in air and nitrogen gas carries. The TG-FTIR-MS technique was employed to study decomposition pathway. The dehydration process was discussed in relation to of the nature of water contained in the compounds.

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“…Daily flavonoid intake (typically present in onion, apple, grape, wine, herbs and spices) in the human diet is highly variable, with estimations ranging from 23 mg/ day [1] to more than 500 mg/day [2]. Flavonoids exert several biological activities, which are mainly related to their ability to inhibit enzymes and/or to their antioxidant properties, and are able to regulate the immune response [3].…”

Section: Introductionmentioning

confidence: 99%

In vivo quercitrin anti‐inflammatory effect involves release of quercetin, which inhibits inflammation through down‐regulation of the NF‐κB pathway

et al. 2005

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Quercetin is a common antioxidant flavonoid found in vegetables, which is usually present in glycosylated forms, such as quercitrin (3-rhamnosylquercetin). Previous in vitro experiments have shown that quercetin exerts a bigger effect than quercitrin in the down-regulation of the inflammatory response. However, such results have not been reproduced in in vivo experimental models of intestinal inflammation, in which quercetin did not show beneficial effects while its glycosides, quercitrin or rutin, have demonstrated their effectiveness. In this study, we have reported that the in vivo effects of quercitrin in the experimental model of rat colitis induced by dextran sulfate sodium can be mediated by the release of quercetin generated after glycoside's cleavage by the intestinal microbiota. This is supported by the fact that quercetin, but not quercitrin, is able to down-regulate the inflammatory response of bone marrow-derived macrophages in vitro. Moreover, we have demonstrated that quercetin inhibits cytokine and inducible nitric oxide synthase expression through inhibition of the NF-jB pathway without modification of c-Jun N-terminal kinase activity (both in vitro and in vivo). As a conclusion, our report suggests that quercitrin releases quercetin in order to perform its anti-inflammatory effect which is mediated through the inhibition of the NF-jB pathway.

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Bioavailability, metabolism and physiological impact of 4-oxo-flavonoids

Cited by 204 publications

References 131 publications

Effects of Ground Thyme and Probiotic Supplements in Diets on Broiler Performance, Blood Biochemistry and Immunological Response to Sheep Red Blood Cells

Effects of Ground Thyme and Probiotic Supplements in Diets on Broiler Performance, Blood Biochemistry and Immunological Response to Sheep Red Blood Cells

New sulfonic derivatives of quercetin as complexing reagents: synthesis, spectral, and thermal characterization

In vivo quercitrin anti‐inflammatory effect involves release of quercetin, which inhibits inflammation through down‐regulation of the NF‐κB pathway

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