Bioavailability enhancement of vitamin E TPGS liposomes of nintedanib esylate: formulation optimization, cytotoxicity and pharmacokinetic studies

Kala, Shabari Girinath; Chinni, Santhivardhan

doi:10.1007/s13346-022-01148-z

Cited by 14 publications

(6 citation statements)

References 35 publications

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“…While liposomal encapsulation technology has been used to enhance drug delivery to tissues, there has also been interest in use of this technology in nutraceutical applications [5]. For example, liposomal encapsulation has been used to enhance the absorption and delivery of vitamin C [6][7][8][9], folate [10,11], vitamin A [12,13], vitamin D [14,15], vitamin E [15][16][17], calcium [18], and iron [19,20], among other nutrients [12,[21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetic Analyses of Liposomal and Non-Liposomal Multivitamin/Mineral Formulations

Yoo

Xing

et al. 2023

Nutrients

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Recent research supports previous contentions that encapsulating vitamins and minerals with liposomes help improve overall bioavailability. This study examined whether ingesting a liposomal multivitamin and mineral supplement (MVM) differentially affects the appearance and/or clearance of vitamins and minerals in the blood compared to a non-liposomal MVM supplement. In a double-blind, randomized, and counterbalanced manner, 34 healthy men and women fasted for 12 h. Then, they ingested a non-liposomal (NL) or liposomal (L) MVM supplement and a standardized snack. Venous blood samples were obtained at 0, 2, 4, and 6 h after MVM ingestion and analyzed for a panel of vitamins and minerals. Plasma levels of vitamins and minerals and mean changes from baseline with 95% confidence intervals (CIs) were analyzed using general linear model statistics with repeated measures. The observed values were also entered into pharmacokinetic analysis software and analyzed through univariate analysis of variance with repeated measure contrasts. The results revealed an overall treatment x time interaction effect among the vitamins and minerals evaluated (p = 0.051, ηp2 = 0.054, moderate effect). Differences between treatments were also observed in volume distribution area (vitamin E, iron), median residence time (vitamin E, iron), volume distribution area (iron), volume of distribution steady state (vitamin A, E, iron), clearance rates (vitamin A, E), elimination phase half-life (vitamin E, iron), distribution/absorption phase intercept (vitamin A), and distribution/absorption phase slope and rate (vitamin C, calcium). Vitamin volume distribution was lower with liposomal MVM ingestion than non-liposomal MVM sources, suggesting greater clearance and absorption since similar amounts of vitamins and minerals were ingested. These findings indicate that coating a MVM with liposomes affects individual nutrient pharmacokinetic profiles. Additional research should evaluate how long-term supplementation of liposomal MVM supplements may affect vitamin and mineral status, nutrient function, and/or health outcomes.

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Section: Introductionmentioning

confidence: 99%

Pharmacokinetic Analyses of Liposomal and Non-Liposomal Multivitamin/Mineral Formulations

Yoo

Xing

et al. 2023

Nutrients

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“…The same approach was utilized to fabricate targeted liposomes, with an additional step of conjugation of the targeting moiety by using carbodiimide chemistry. After the formulation of TPGS-COOH coated liposomes, they were post decorated with targeting ligands such as RGD or AM , depicted in Figure B.…”

Section: Methodsmentioning

confidence: 99%

Nattokinase Encapsulated Nanomedicine for Targeted Thrombolysis: Development, Improved in Vivo Thrombolytic Effects, and Ultrasound/Photoacoustic Imaging

Priya,

Samridhi,

Singh

et al. 2023

Mol. Pharmaceutics

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“…Based on the pharmacokinetic data prepared liposomal shows bout 6% times greater oral bioavailability compared to marketed formulation. Hence the prepared formulation shows prolonged drug release with improved bioavailability [40].…”

Section: Liposomesmentioning

confidence: 99%

Lipid as a Vehicle/Carrier for Oral Drug Delivery

Desai¹,

Desai²,

Patel³

2023

Drug Formulation Design

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The drug administered by an oral route has to withstand a harsh environment of gastrointestinal media, absorb through intestinal epithelium and circumvent first-pass metabolism in liver before reaching portal blood circulation. Moreover, hydrophobic drug molecules offer challenges for formulation with respect to their solubility and hence bioavailability. Various approaches have been developed to overcome this barrier. One of them is the use of lipids in formulation. Incorporation of the drug in lipids can result in increased solubility, absorption and thereby enhanced bioavailability. Intestinal lymphatic route of absorption has also been explored for increasing bioavailability of hydrophobic drug moieties. In this chapter, we have discussed the pathway of lipid digestion in the human body as well as the mechanism of lipid particles upon oral administration. The various lipid formulations developed and the excipients used in the formulations have also been described. The importance of lipid chain length and the effect of food in increasing the bioavailability of drug is discussed. The lymphatic pathway of lipid carriers has also been discussed.

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Bioavailability enhancement of vitamin E TPGS liposomes of nintedanib esylate: formulation optimization, cytotoxicity and pharmacokinetic studies

Cited by 14 publications

References 35 publications

Pharmacokinetic Analyses of Liposomal and Non-Liposomal Multivitamin/Mineral Formulations

Pharmacokinetic Analyses of Liposomal and Non-Liposomal Multivitamin/Mineral Formulations

Nattokinase Encapsulated Nanomedicine for Targeted Thrombolysis: Development, Improved in Vivo Thrombolytic Effects, and Ultrasound/Photoacoustic Imaging

Lipid as a Vehicle/Carrier for Oral Drug Delivery

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