Bioavailability Effect of Methylprednisolone by Polymeric Micelles

Abstract

PM vehicle was able to deliver MP to improve its pharmacokinetic profile in plasma and SC with higher expression of anti-apoptotic Bcl-x(L) at both mRNA and protein levels.

Neuroprotective ferulic acid (FA)–glycol chitosan (GC) nanoparticles for functional restoration of traumatically injured spinal cord

“…Although various polymers or nanomaterials have been used for early SCI treatment, they had to be administrated within a short period (less than 15 min) after SCI or even before SCI to achieve distinct therapeutic effect [23, 50-52]. Such time windows are not clinically relevant for clinical SCI treatment because it generally requires at least 1 or 2 hours for patient transfer to an emergency department and diagnostic assessment before initial treatment.…”

Zonisamide-loaded triblock copolymer nanomicelles as a novel drug delivery system for the treatment of acute spinal cord injury

“…19 There have been several reports of biodegradable polymeric micelles for SCI treatment. 20 Chen et al 21 improved the bioavailability of MP in the spinal cord using poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) polymeric micelles as a delivery vehicle. In addition, self-assembled monomethoxy poly(ethylene glycol)-poly(d,l-lactic acid) di-block copolymer micelles (MPEG-PDLLA) have been demonstrated to be effective in restoring compound action potentials (CAPs) of the injured spinal cord, decreasing calcium influx into axons and promoting the recovery of locomotion function in an SCI rat model.…”

Nanomedicine for treating spinal cord injury

“…As both fields continue to advance, a combined approach could help us realize the goal of functional recovery much faster than either field could on its own. NPs, 75, 76 liposomes, 94, 95 and micelles 59 have shown the ability to increase bioavailability of neuroprotective therapies to the spinal cord after injection. Such improvements in delivery have the capability of improving clinical outcomes by reducing the required dosages and systemic toxicity of current treatments.…”

“…59, 60 Micelles are formed from self-assembling amphiphilic molecules, consisting of a hydrophobic core and a hydrophilic shell. Hydrophobic drug can be encapsulated in the core, which protects it from degradation and improves the drug's circulation half-life.…”

“…Chen et al improved the bioavailability of MP in the spinal cord using Poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO, Pluronic) polymeric micelles as a delivery vehicle 59 . Like PEG, Pluronic is a popular component of drug delivery systems and has been shown to cross the blood-brain barrier.…”