Bioavailability and pharmacokinetics of cimetidine

Grahnén, A; Bahr, Christer von; Lindström, Björn; Rosén, Anders

doi:10.1007/bf00605632

Cited by 87 publications

(47 citation statements)

References 16 publications

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“…The mechanism of the second peak has not been adequately explained. Possible causes are irregular absorption in the gastrointestinal tract, enterohepatic circulation, or the reduction of the sulphoxide metabolite of cimetidine back to intact cimetidine caused by faecal bacteria (Spence, Greak & Celestine, 1977;Taylor, Gresswell & Bartlett, 1978;Grahnen et al, 1979). In the present study metoclopramide abolished the second peak and consequently reduced the AUC.…”

Section: The Effect Of Metoclopramide and Propantheline On The Gastrosupporting

confidence: 50%

“…The combination drug therapy may be appropriate in the refractory cases (Finkelstein & Isselbacher, 1978). Despite the rapidly gained and widespread use in the treatment of duodenal and gastric ulcer, few studies have been published on the pharmacokinetics of cimetidine (Grahnen, von Bahr, Lindstrom & Rosen, 1979). In this work we have studied the simultaneous effect of relatively large dose of metoclopramide and propantheline on the gastrointestinal absorption of cimetidine.…”

Section: The Effect Of Metoclopramide and Propantheline On The Gastromentioning

confidence: 99%

“…Generally, two marked peaks have been found in the gastrointestinal absorption of cimetidine (Griffiths, Lee & Taylor, 1977;Walkenstein, Dubb, Randolph, Westlake, Stote & Intoccia, 1978;Bodemar, Norlander, Fransson & Wahlan, 1979;Grahnen et al, 1979). The mechanism of the second peak has not been adequately explained.…”

Section: The Effect Of Metoclopramide and Propantheline On The Gastromentioning

confidence: 99%

“…Bioavailability studies using AUC-values seem to be misleading for drugs which behave like cimetidine, because AUCs after oral doses exceed those after intravenous injection (Grahnen et al, 1979).…”

Section: The Effect Of Metoclopramide and Propantheline On The Gastromentioning

confidence: 99%

See 3 more Smart Citations

The effect of metoclopramide and propantheline on the gastrointestinal absorption of cimetidine.

Kanto¹,

Allonen²,

Jalonen³

et al. 1981

Brit J Clinical Pharma

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Section: The Effect Of Metoclopramide and Propantheline On The Gastrosupporting

confidence: 50%

Section: The Effect Of Metoclopramide and Propantheline On The Gastromentioning

confidence: 99%

Section: The Effect Of Metoclopramide and Propantheline On The Gastromentioning

confidence: 99%

Section: The Effect Of Metoclopramide and Propantheline On The Gastromentioning

confidence: 99%

See 2 more Smart Citations

The effect of metoclopramide and propantheline on the gastrointestinal absorption of cimetidine.

Kanto¹,

Allonen²,

Jalonen³

et al. 1981

Brit J Clinical Pharma

View full text Add to dashboard Cite

“…According to several studies the inhibition of gastric acid secretion is directly related to the blood concentration of cimetidine (Henn et al, 1975;Pounder et al, 1976;Aadland, Berstad & Semb, 1977). Other studies have shown that betweensubject variations of cimetidine blood levels are considerable (Bodemar et al, 1979;Redolfi, 0306-5251/81/090417-05 $01.00 Borgogelli & Lodola, 1979;Grahnen et al, 1979;Rune, Hesselfeldt & Larssen, 1979). This variation in blood cimetidine levels, therefore, might influence the clinical response to treatment with cimetidine.…”

Section: Introductionmentioning

confidence: 98%

Is the measurement of blood cimetidine levels useful?

Festen¹,

Diemel²,

Schaik³

et al. 1981

Brit J Clinical Pharma

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1 Blood cimetidine levels were measured up to 5 h after oral intake of 200 mg cimetidine with breakfast in 13 duodenal, 5 gastric and 15 anastomotic ulcer patients. 2 There were larger inter individual differences in results. The mean peak blood concentrations was 1.14 +/‐ 0.07 microgram/ml (range 0.54‐1.94 microgram/ml), the mean period during which the blood concentration exceeded 0.5 microgram/ml was 141 +/‐ 11 min (range 23‐306 min) and the mean area under the cimetidine blood concentration curve (AUC) was 166 +/‐ 8 microgram ml‐1 min (range 96‐280 microgram ml‐1 min). Coefficient of variation of these parameters was 33%, 43% and 29% respectively. 3 There were no significant differences in these parameters between non‐operated patients and patients with a partial gastrectomy. 4 In 11 patients restudied after 2 to 5 months blood cimetidine levels proved well reproducible; mean coefficient of variation of peak blood levels was 8.5 +/‐ 2.4%, of time during which blood levels exceeded 0.5 microgram/ml 7.6 +/‐ 2.5% and of the AUC 5.0 +/‐ 1.0%. 5 There was no difference in peak blood levels, duration of blood level exceeding 0.5 microgram/ml and blood cimetidine AUC between 24 patients healed after 4 weeks cimetidine therapy and 9 in whom healing took longer. Likewise, there was no evidence of lower blood cimetidine concentrations in 9 patients who relapsed during maintenance cimetidine treatment compared with 24 who did not relapse.

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Pharmacokinetics of single oral and multiple intravenous and oral administration of acebutolol enantiomers in a rat model

Mostafavi

Foster

1998

Biopharm. Drug Dispos.

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Bioavailability and pharmacokinetics of cimetidine

Cited by 87 publications

References 16 publications

The effect of metoclopramide and propantheline on the gastrointestinal absorption of cimetidine.

The effect of metoclopramide and propantheline on the gastrointestinal absorption of cimetidine.

Is the measurement of blood cimetidine levels useful?

Pharmacokinetics of single oral and multiple intravenous and oral administration of acebutolol enantiomers in a rat model

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