Bioavailability and Bioactivities of Polyphenols Eco Extracts from Coffee Grounds after In Vitro Digestion

Vamanu, Emanuel; Gatea, Florentina; Pelinescu, Diana

doi:10.3390/foods9091281

Cited by 19 publications

(14 citation statements)

References 45 publications

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“…The focus on chlorogenic acid is due to its potential health bene ts described in previous studies, including free radical scavenging capacity, antiin ammatory, antidiabetic, and anticancer effects 20 . Cinnamic acid, which is predominant in the present study in agreement with Vamanu et al 21 , has generally been reported to be phenolic constituents in SCG in previous research but in much lower concentrations with respect to the extraction technique 22 . As explained above, the variations might be due to many reasons, including solvent, solvent/sample ratio, extraction time, extraction method, and temperature.…”

Section: Resultssupporting

confidence: 93%

The Valorization of Spent Coffee Grounds Extract as A Prospective Insecticidal Agent Against Some Main Key Pests of Phesolus Vulgaris in Laboratory and Field

Hussein

Abouamer

Ali³

et al. 2021

Preprint

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Exploiting massive amounts of food and agro-waste represents a severe social, economic, and environmental issue. Under the growing demand toward food products free of toxic synthetic insecticides, the methanolic extract of spent coffee grounds (SCGs), which represent the main by-product of coffee production, was applied in the current study as a bioinsecticide against the main pests of the green bean; Spodoptera littoralis, Agrotis ipsilon, Bemisia tabaci, Empoasca fabi and Aphis craccivora. Deterrent assay, contact bioassay, and lethal concentration analysis were performed to reveal the repellent, antifeedant, and oviposition deterrent effects. Parallel to the above-performed bioassays, the phytochemical composition of the SCGs methanolic extract was investigated via High-Performance Liquid Chromatography (HPLC) analysis. Fourteen phenolic acids and five flavonoids in addition to caffeine (alkaloid) have been identified in the extract. Cinnamic, rosmarinic, and gallic acids were the predominant phenolics, while apigenin-7-glucoside was the main flavonoid, followed by naringin, catechin, and epicatechin. The extract of SCGs showed an insecticidal effect, with mortality between 27.5-76% compared to the control (7.4%) and based on the concentration of the extract used. In the same trend, oviposition efficiency revealed different laid egg batches (0.67, 2.33, 7.33, and 8.67 batch/jar) for 100, 50, 25% of the SCGs extract and control. Finally, the major components of SCGs extract were docked into insecticide acetylcholinesterase enzyme to explore their potential of inhibition, where apigenin-7-glucoside showed a higher binding affinity, followed by catechin, compared to the control (lannate). Obtained findings could be a starting point to develop novel bioinsecticides from SCGs.

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Section: Resultssupporting

confidence: 93%

The Valorization of Spent Coffee Grounds Extract as A Prospective Insecticidal Agent Against Some Main Key Pests of Phesolus Vulgaris in Laboratory and Field

Hussein

Abouamer

Ali³

et al. 2021

Preprint

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“…The differences were assessed by analysis of variance (ANOVA) followed by a Tukey post-hoc analysis. The experimental data analysis and correlation were performed using the IBM SPSS Statistics software package (IBM Corporation, Armonk, NY, USA) [30,31].…”

Section: Discussionmentioning

confidence: 99%

In Vitro Coliform Resistance to Bioactive Compounds in Urinary Infection, Assessed in a Lab Catheterization Model

Vamanu

Dinu

Luntraru³

et al. 2021

Applied Sciences

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Bioactive compounds and phenolic compounds are viable alternatives to antibiotics in recurrent urinary tract infections. This study aimed to use a natural functional product, based on the bioactive compounds’ composition, to inhibit the uropathogenic strains of Escherichia coli. E. coli ATCC 25922 was used to characterize the IVCM (new in vitro catheterization model). As support for reducing bacterial proliferation, the cytotoxicity against a strain of Candida albicans was also determined (over 75% at 1 mg/mL). The results were correlated with the analysis of the distribution of biologically active compounds (trans-ferulic acid-268.44 ± 0.001 mg/100 g extract and an equal quantity of Trans-p-coumaric acid and rosmarinic acid). A pronounced inhibitory effect against the uropathogenic strain E. coli 317 (4 log copy no./mL after 72 h) was determined. The results showed a targeted response to the product for tested bacterial strains. The importance of research resulted from the easy and fast characterization of the functional product with antimicrobial effect against uropathogenic strains of E. coli. This study demonstrated that the proposed in vitro model was a valuable tool for assessing urinary tract infections with E. coli.

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“…The standard and sample solutions were diluted in methanol. The identification of the compounds was realized by the addition of standards, and the retention times were compared at λ = 280 nm [8]. The linearity of the response was established for each polyphenol by building the calibration curves.…”

Section: Equipment and Methodsmentioning

confidence: 99%

“…Banana peels extract has such use in reducing oxidative stress, a major cause of many chronic diseases [7]. In direct relation with the characterization of the biological effect and the phytochemical profile [8], will determine the procurement of competitive products that help increase the products' efficacy [9]. That may include biopharmaceutical compounds integrated into the cosmetic products [10].…”

Section: Introductionmentioning

confidence: 99%

Functional Compounds from Banana Peel Used to Decrease Oxidative Stress Effects

2022

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Banana peel, a little-used waste, contains a high amount of biologically active compounds. The aim of the study is to demonstrate in vitro, the antioxidant, cytotoxic, and antimicrobial effects of hydroalcoholic extracts from yellow (BP) and red (BPR) banana peels. The analysis of the extracts by Capillary Zone Electrophoresis (CZE) has confirmed the presence of several bioactive compounds. BPR has a higher in vitro antioxidant activity than BP, which correlates with a significant cytotoxic, antimicrobial effect, with a UVA/UVB rate of 0.9. In the case of BPR, the results confirm the presence of isoquercitrin and kaempferol in a 1:3 ratio. The bioactive compounds from the extracts have shown a different interaction with HCT-8 cell lines and with tested bacterial strains with pathogenic properties. The HCA analysis proved the biological value of BPR to reduce oxidative stress and its potential use in natural products.

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Bioavailability and Bioactivities of Polyphenols Eco Extracts from Coffee Grounds after In Vitro Digestion

Cited by 19 publications

References 45 publications

The Valorization of Spent Coffee Grounds Extract as A Prospective Insecticidal Agent Against Some Main Key Pests of Phesolus Vulgaris in Laboratory and Field

The Valorization of Spent Coffee Grounds Extract as A Prospective Insecticidal Agent Against Some Main Key Pests of Phesolus Vulgaris in Laboratory and Field

In Vitro Coliform Resistance to Bioactive Compounds in Urinary Infection, Assessed in a Lab Catheterization Model

Functional Compounds from Banana Peel Used to Decrease Oxidative Stress Effects

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