Bioavailability and bioaccessibility of food bioactive compounds; overview and assessment by <i>in vitro</i> methods

Dima, Cristian; Assadpour, Elham; Dima, Ştefan; Jafari, Seid Mahdi

doi:10.1111/1541-4337.12623

Cited by 146 publications

(104 citation statements)

References 85 publications

Supporting

Mentioning

100

Contrasting

Order By: Relevance

“…Bioaccessibility, that is, the release from the matrix, is a preliminary and important requirement for further absorption of food components. Food component bioaccessibility is not only dependent on their concentration, as food matrix composition and structure also affect the release kinetics during the digestive process [1][2][3][4]. The molecular organization of the food matrix is a determining factor since the spatial distribution of molecules, that is, the supramolecular structure, influences the order of substrate exposure to the digestive enzymes [5].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Balsamic Vinegar Dressing on Protein and Carbohydrate Digestibility is Dependent on the Food Matrix

Urbinati

Nunzio

Picone

et al. 2021

Foods

View full text Add to dashboard Cite

The balsamic vinegar of Modena (BVM), a food specialty under the European Protected Geographical Indication system, is made from grape must blended with wine vinegar exclusively in the Italian province of Modena or Reggio Emilia. Vinegar is associated to an improved digestive function and glycemic response to carbohydrate-rich meals, appetite stimulation, and reduction of hyperlipidemia and obesity. Although many of these effects are attributed to the high concentration of bioactive molecules, the modulation of digestive enzymes activity could have a role. The aim of this study was to investigate the effect of BVM on the digestibility and component release of three foods that are often seasoned with this dressing but have different composition: Parmigiano Reggiano cheese, Bresaola (cured meat), and boiled potatoes. BVM modulated the protein digestion of protein-rich foods (cheese and cured meat) in a matrix-dependent manner, and the BVM effect was mainly related to the inhibition of pepsin in the gastric phase. In the starch-rich food (boiled potatoes), the most impressive effect of BVM was the lower release of anomeric and total carbohydrates, which was consistent with the observed reduction of pancreatic amylase activity. The present investigation shed a new light on the impact of BVM on the digestion process.

show abstract

Section: Introductionmentioning

confidence: 99%

The Effect of Balsamic Vinegar Dressing on Protein and Carbohydrate Digestibility is Dependent on the Food Matrix

Urbinati

Nunzio

Picone

et al. 2021

Foods

View full text Add to dashboard Cite

show abstract

“…Metoprolol is commonly used as a reference [151], because its gastrointestinal membrane permeability lies in this boundary range. [153] Regarding the LogP value, it may be considered as a helpful instrument to investigate drugs' bioavailability, but effective absorption and metabolism mechanism are much more complex, and specific enzyme and sites interaction also play a relevant role. As an 0.15 0.47 ± 0.01 [55] −2.28 [150] −0.9 [ Regarding the LogP value, it may be considered as a helpful instrument to investigate drugs' bioavailability, but effective absorption and metabolism mechanism are much [153] Regarding the LogP value, it may be considered as a helpful instrument to investigate drugs' bioavailability, but effective absorption and metabolism mechanism are much more complex, and specific enzyme and sites interaction also play a relevant role.…”

Section: Logpmentioning

confidence: 99%

“…[153] Regarding the LogP value, it may be considered as a helpful instrument to investigate drugs' bioavailability, but effective absorption and metabolism mechanism are much more complex, and specific enzyme and sites interaction also play a relevant role. As an 0.15 0.47 ± 0.01 [55] −2.28 [150] −0.9 [ Regarding the LogP value, it may be considered as a helpful instrument to investigate drugs' bioavailability, but effective absorption and metabolism mechanism are much [153] Regarding the LogP value, it may be considered as a helpful instrument to investigate drugs' bioavailability, but effective absorption and metabolism mechanism are much more complex, and specific enzyme and sites interaction also play a relevant role. As an [153] Regarding the LogP value, it may be considered as a helpful instrument to investigate drugs' bioavailability, but effective absorption and metabolism mechanism are much more complex, and specific enzyme and sites interaction also play a relevant role.…”

Section: Logpmentioning

confidence: 99%

An Overview on Dietary Polyphenols and Their Biopharmaceutical Classification System (BCS)

Truzzi

Tibaldi

Zhang

et al. 2021

IJMS

View full text Add to dashboard Cite

Polyphenols are natural organic compounds produced by plants, acting as antioxidants by reacting with ROS. These compounds are widely consumed in daily diet and many studies report several benefits to human health thanks to their bioavailability in humans. However, the digestion process of phenolic compounds is still not completely clear. Moreover, bioavailability is dependent on the metabolic phase of these compounds. The LogP value can be managed as a simplified measure of the lipophilicity of a substance ingested within the human body, which affects resultant absorption. The biopharmaceutical classification system (BCS), a method used to classify drugs intended for gastrointestinal absorption, correlates the solubility and permeability of the drug with both the rate and extent of oral absorption. BCS may be helpful to measure the bioactive constituents of foods, such as polyphenols, in order to understand their nutraceutical potential. There are many literature studies that focus on permeability, absorption, and bioavailability of polyphenols and their resultant metabolic byproducts, but there is still confusion about their respective LogP values and BCS classification. This review will provide an overview of the information regarding 10 dietarypolyphenols (ferulic acid, chlorogenic acid, rutin, quercetin, apigenin, cirsimaritin, daidzein, resveratrol, ellagic acid, and curcumin) and their association with the BCS classification.

show abstract

“…Bioefficiency of a nanoencapsulated material is a vital criterion to meet the metabolic needs of a consumer. Quantitative estimation of bioefficiency is usually done by determination of bioaccessibility, bioavailability and biological activity of consumed food components [ 119 ]. Bioavailability of a compound is defined as the fraction of functional component absorbed and reaching the systemic blood circulation for performing physiological functions and/or biodistribution ( Figure 16 A).…”

Section: In Vitro Release Gastrointestinal Absorption and Bioaccessibility/bioavailabilitymentioning

confidence: 99%

Recent Advances on Nanoparticle Based Strategies for Improving Carotenoid Stability and Biological Activity

2021

View full text Add to dashboard Cite

Carotenoids are natural pigments widely used in food industries due to their health-promoting properties. However, the presence of long-chain conjugated double bonds are responsible for chemical instability, poor water solubility, low bioavailability and high susceptibility to oxidation. The application of a nanoencapsulation technique has thus become a vital means to enhance stability of carotenoids under physiological conditions due to their small particle size, high aqueous solubility and improved bioavailability. This review intends to overview the advances in preparation, characterization, biocompatibility and application of nanocarotenoids reported in research/review papers published in peer-reviewed journals over the last five years. More specifically, nanocarotenoids were prepared from both carotenoid extracts and standards by employing various preparation techniques to yield different nanostructures including nanoemulsions, nanoliposomes, polymeric/biopolymeric nanoparticles, solid lipid nanoparticles, nanostructured lipid nanoparticles, supercritical fluid-based nanoparticles and metal/metal oxide nanoparticles. Stability studies involved evaluation of physical stability and/or chemical stability under different storage conditions and heating temperatures for varied lengths of time, while the release behavior and bioaccessibility were determined by various in vitro digestion and absorption models as well as bioavailability through elucidating pharmacokinetics in an animal model. Moreover, application of nanocarotenoids for various biological applications including antioxidant, anticancer, antibacterial, antiaging, cosmetics, diabetic wound healing and hepatic steatosis were summarized.

show abstract

Bioavailability and bioaccessibility of food bioactive compounds; overview and assessment by in vitro methods

Cited by 146 publications

References 85 publications

The Effect of Balsamic Vinegar Dressing on Protein and Carbohydrate Digestibility is Dependent on the Food Matrix

The Effect of Balsamic Vinegar Dressing on Protein and Carbohydrate Digestibility is Dependent on the Food Matrix

An Overview on Dietary Polyphenols and Their Biopharmaceutical Classification System (BCS)

Recent Advances on Nanoparticle Based Strategies for Improving Carotenoid Stability and Biological Activity

Contact Info

Product

Resources

About