Bioassay-guided isolation of iridoid glucosides with antinociceptive and anti-inflammatory activities from Veronica anagallis-aquatica L.

Küpeli, Esra; Harput, Ü. Şebnem; Varel, Mehtap; Yeşilada, Erdem; Saraçoğlu, İclal

doi:10.1016/j.jep.2005.05.042

Cited by 52 publications

(48 citation statements)

References 14 publications

(16 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The most active iridoid was geniposidic acid (1) (91.01% ± 3.87% inhibition). Previous studies observed the increased anti-inflammatory activity of geniposidic acid (1) on carrageenan-induced hind paw edema in mice (53.3% ± 4.8% inhibition) in comparison with the control indomethacin (33.0% ± 3.1% inhibition) [8].…”

Section: Mg/earmentioning

confidence: 83%

“…The inhibitory effect of the mediators of lipopolysaccharide and IFN-γ stimulated macrophages showed the potent inhibition of NO, TNF-α, and IL-12 [17] and selective inhibition of COX-2 [18,19]. In an attempt to identify the preliminary structure and activity relationship of the iridoids isolated from Castilleja tenuiflora, we acquired geniposide (8) and loganic acid (7) to demonstrate the influence of the electron withdrawing group in position 11 of the basic structure of an iridoid. We did not find a relationship between the structure and activity of the different iridoids evaluated.…”

Section: Mg/earmentioning

confidence: 99%

See 1 more Smart Citation

Anti-Inflammatory Activity of Iridoids and Verbascoside Isolated from Castilleja tenuiflora

et al. 2013

View full text Add to dashboard Cite

Castilleja tenuiflora (Orobanchaceae) has been used in Mexican traditional medicine as a treatment for cough, dysentery, anxiety, nausea and vomiting as well as hepatic and gastrointestinal diseases. The ethanolic extract of the aerial parts of Castilleja tenuiflora was separated by silica gel column chromatography. The fractions were evaluated using the induced edema acetate 12-O-tetradecanoylphorbol (TPA) anti-inflammatory activity model. The most active fraction was subjected to medium-pressure liquid chromatography (MPLC) with UV detection at 206 and 240 nm. The following iridoids were isolated: geniposidic acid, aucubin, bartioside, 8-epi-loganin, mussaenoside, and the phenylpropanoid verbascoside. The most active iridoid was geniposidic acid, which was more active than the control (indomethacin), and the least active iridoid was mussaenoside. 8-epi-Loganin, and mussaenoside have not been previously reported to be anti-inflammatory compounds. The results of these investigations confirm the potential of 12110Mexican plants for the production of bioactive compounds and validate the ethnomedical use of Castilleja tenuiflora-like anti-inflammatory plants.

show abstract

Section: Mg/earmentioning

confidence: 83%

Section: Mg/earmentioning

confidence: 99%

Anti-Inflammatory Activity of Iridoids and Verbascoside Isolated from Castilleja tenuiflora

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Carrageenan-induced hind paw edema model Carrageenan-induced hind paw edema model was used for the determination of the anti-inflammatory activity (Küpeli et al, 2005). The difference in footpad thickness between the right and left foot was measured with a pair of dial thickness gauge calipers (Ozaki Co., Tokyo, Japan).…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Antinociceptive and Anti-Inflammatory Effects of Saponin and Iridoid Glycosides from Verbascum pterocalycinum var. mutense Hub.-Mor.

Akkol

Tatlı

Akdemir

2007

Zeitschrift Für Naturforschung C

View full text Add to dashboard Cite

The anti-inflammatory and antinociceptive properties of four major compounds from the flowers of Verbascum pterocalycinum var. mutense were investigated. Saponin glycosides called ilwensisaponin A and C and iridoid glycosides known as ajugol and picroside IV were isolated from the methanolic extract. A dose-related anti-inflammatory and antinociceptive response were obtained in this study at doses of 100 and 200 mg/kg. The results of the evaluation of the anti-inflammatory activity induced by carrageenan and PGE 1 showed that this species possesses active constituents that could diminish the cyclooxygenase activitiy. No effects were observed in the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear edema model. Our results support the anti-inflammatory and analgesic effects of Verbascum pterocalycinum var. mutense. Ilwensisaponins A and C could explain in part the anti-inflammatory and analgesic activities of this species. Although antinociceptive and anti-inflammatory activities of ajugol and picroside IV were found insignificant in the statistical analysis, ilwensisaponin A and C showed notable activity without inducing any apparent acute toxicity as well as gastric damage.

show abstract

“…In Chinese traditional medicine, Veronica species are used as expectorants, restoratives, tonics, and for treatment of influenza and other respiratory diseases [8]. Extracts obtained from above-ground parts of certain Veronica species are used as folk remedies for treatment of various inflammatory ailments, including rheumatism [9]. In addition, stems and leaves of some Veronica species are edible, either raw or cooked [10].…”

Section: Introductionmentioning

confidence: 99%

In vivo and in vitro antioxidant effects of three Veronica species

2012

View full text Add to dashboard Cite

The aim of the present study was to examine the antioxidant activity of three Veronica species (Plantaginaceae). The antioxidant potential of various extracts obtained from aerial flowering parts was evaluated by DPPH-free (1,1-diphenyl-2-picrylhydrazyl-free) radical scavenging activity and ferric-reducing antioxidant power assays. Considerable antioxidant activity was observed in the plant samples (FRAP values ranged from 0.97 to 4.85 mmol Fe2+/g, and DPPH IC50 values from 12.58 to 66.34 µg/ml); however, these levels were lower than the activity of the control compound butylated hydroxytoluene (BHT) (FRAP: 10.58 mmol Fe2+/g; DPPH IC50: 9.57 µg/ml). Also, the in vivo antioxidant effects were evaluated in several hepatic antioxidant systems in rats (activities of glutathione peroxidase, glutathione reductase, peroxidase, catalase, xanthine oxidase, glutathione content and level of thiobarbituric acid reactive substances) after treatment with different Veronica extracts, or in combination with carbon tetrachloride (CCl4). Pretreatment with 100 mg/kg b.w. of Veronica extracts inhibited CCl4-induced liver injury by decreasing TBA-RS level, increasing GSH content, and bringing the activities of CAT and Px to control levels. The present study suggests that the extracts analyzed could protect the liver cells from CCl4-induced liver damage by their antioxidative effect on hepatocytes.

show abstract

Bioassay-guided isolation of iridoid glucosides with antinociceptive and anti-inflammatory activities from Veronica anagallis-aquatica L.

Cited by 52 publications

References 14 publications

Anti-Inflammatory Activity of Iridoids and Verbascoside Isolated from Castilleja tenuiflora

Anti-Inflammatory Activity of Iridoids and Verbascoside Isolated from Castilleja tenuiflora

Antinociceptive and Anti-Inflammatory Effects of Saponin and Iridoid Glycosides from Verbascum pterocalycinum var. mutense Hub.-Mor.

In vivo and in vitro antioxidant effects of three Veronica species

Contact Info

Product

Resources

About