Bioartificial polymeric materials based on polysaccharides

Cascone, Maria Grazia; Barbani, Niccoletta; Cristallini, Caterina; Giusti, P.; Ciardelli, Gianluca; Lazzeri, Luigi

doi:10.1163/156856201750180807

Cited by 168 publications

(71 citation statements)

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“…10 Chitosans can exist in many structural conformations, depending on a variety of factors that include the degree of hydration, the counterion mixture, and the complexity of the original chitin mixture. 11 Chitin-and chitosan-based products have been advanced for a wide variety of applications, including wound healing, 12 pharmaceutical formulation, [12][13][14][15][16] tissue engineering, [17][18][19][20][21] and surface hemostasis. 22,23 However, medical product development with these materials has been hampered by the chemical and physical heterogeneity of the polymer products and contamination of preparations by proteins and other components.…”

Section: Introductionmentioning

confidence: 99%

Hemostatic properties of glucosamine‐based materials

Fischer

Bode

Demcheva

et al. 2006

J Biomedical Materials Res

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Glucosamine-and N-acetyl glucosamine-containing polymers are being used in an increasing number of biomedical applications, including in products for surface (topical) hemostasis. The studies presented here investigate the relationship between the structure (conformation) and function (activation of hemostasis) of glucosamine-based materials. Several polymer systems were studied, including fibers isolated from a microalgal source containing poly-N-acetyl glucosamine polymers that are organized in a parallel, hydrogen-bonded tertiary structure and can be chemically modified to an antiparallel orientation; and gel formulation derivatives of the microalgal fibers consisting of partially deacetylated (F2 gel) and fully deacetylated (F3 gel) polymers. Comparison of the properties of the poly-N-acetyl glucosamine fiber-derived materials with chitin, chitosan, and commercial chitosan-based products are presented. Several studies were performed with the glucosamine-based materials, including (1) an analysis of the ability of materials to activate platelets and turnover of the intrinsic coagulation cascade, (2) an examination of the viscoelastic properties of mixtures of platelet-rich plasma and the glucosamine-based materials via thromboelastography, and (3) scanning electron microscopic studies to examine the morphology of the glucosamine-based materials. The results presented demonstrate that hemostatic responses to the glucosamine-based materials studied are highly dependent on their chemical nature and tertiary/quaternary structure. The unique natural microalgal fibers were found to have strongly prohemostatic activity compared to the other materials studied.

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Section: Introductionmentioning

confidence: 99%

Hemostatic properties of glucosamine‐based materials

Fischer

Bode

Demcheva

et al. 2006

J Biomedical Materials Res

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“…2 Hydrogels of natural polymers, especially polysaccharides, have been used recently as biomaterial, because of their unique advantages such as nontoxicity, biocompatibility, biodegradability, and abundance. 3,4 Polysaccharides, as natural biomolecules, are obvious choices for investigation as potential wound management aids. Alginic acid/alginate, hyaluronic acid/ hyaluronate, cellulose, dextran, chitin and chitosan, carrageenan, and heparin are used in wound management aids as dressing materials.…”

Section: Introductionmentioning

confidence: 99%

Radiation synthesis of poly(N‐vinyl‐2‐pyrrolidone)–κ‐carrageenan hydrogels and their use in wound dressing applications. I. Preliminary laboratory tests

Şen

Avcı

2005

J Biomedical Materials Res

100

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Poly(N-vinyl-2-pyrrolidone)--carrageenan hydrogels (PVP-KC) were prepared by irradiating the mixtures of aqueous solutions of PVP, KC, potassium chloride, and poly(ethylene glycol) by ␥-rays at different doses. Their preliminary laboratory tests were evaluated to identify their usability in wound dressing applications. For investigation of the effect of components on the gelation of PVP, sol-gel analyses were made and gel fractions of the hydrogels were determined. Mechanical experiments were conducted for both unirradiated and irradiated samples. For investigation of the fluid uptake capacity of the hydrogels, swelling experiments were performed in pseudo-extracellular fluid solution at various temperatures. Acidity/alkalinity (pH) and electrical conductivity tests were achieved from aqueous extracts of hydrogels, and bioadhesion strength of the hydrogels was investigated on human skin.

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“…The gellan gum (GG) hydrogel composite were prepared using HEPES (50 mM, pH = 4), following proportion: 2% of GG-LA (89.1 COOH) [21] [22]. In short, 6 mL of HEPES and 20μM of solution CYS and GG-LA were mixed, and the resulting dispersion was stirred (using a overhead stirrer at 100 ± 5 rpm) at 80˚C for ten minutes to carry out the crosslinked kelcogell hydrogel production.…”

Section: Preparation Of Hydrogel Compositesmentioning

confidence: 99%

Gold Nanoparticle and Berberine Entrapped into Hydrogel Matrix as Drug Delivery System

Souza¹,

Oliveira²,

Pinheiro³

et al. 2015

JBNB

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In this study the novel hydrogel loaded with gold nanoparticle (AuNP) enhanced the berberine (BS) release when compared with other formulations of hydrogel. Hydrogels are hydrophilic polymer networks having the capacity to absorb water, ranging from about twenty to thousand times their dry weight. BS is a natural product, a quaternary ammonium salt from the group of isoquinoline alkaloids found in medicinal plants as Berberis Vulgaris. BS has some activity against dysentery, hypertension, inflammation, and liver disease in China and Japan. In this work, BS was used as a model drug to study its association with different types of hydrogel composites of polyvinyl alcohol (BS-PVA 10%); gellan gum (BS-GG 2%), gellan gum-PVA crosslinked with cysteine (cys) (BSGG2%PVA2%cys) and gellan gum-PVA cosslinked with cysteine associated with gold nanoparticles (AuNP-BSGG2%PVA2%cys). Several parameters such as fraction of retained water (Wf), hydration percentage (%H), Swelling (DSw) and time course profile (t = 100%) (TC) were evaluated for all preparations. The results showed that the AuNP-BS-GG2%PVA2%cys was able to retain more water and swelling than the other preparations. The time course of release of the BS to the medium was greater for AuNP-BS-GG2%PVA2%cys making it a candidate to drug delivery studies in biological assays. Also Scanning Electron Microscopy (SEM) images of the surface of these hydrogel were performed. Furthermore, crosslink of the resulting hydrogels were investigated by Fourier Transform Infrared Spectroscopy (FTIR) and differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). Thus, briefly, the aim of this work was to study three composition of hydrogel loaded with BS and its composition in relation to addition to AuNP and evaluate its profile for further drug delivery application using the Surface Plasmonic Resonance (SPR) as a tool improving the drug release in the new hydrogel. * Corresponding authors. C. Rufino Souza et al.54

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Bioartificial polymeric materials based on polysaccharides

Cited by 168 publications

References 0 publications

Hemostatic properties of glucosamine‐based materials

Hemostatic properties of glucosamine‐based materials

Radiation synthesis of poly(N‐vinyl‐2‐pyrrolidone)–κ‐carrageenan hydrogels and their use in wound dressing applications. I. Preliminary laboratory tests

Gold Nanoparticle and Berberine Entrapped into Hydrogel Matrix as Drug Delivery System

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