Bioapplications of Nanomaterials

Huynh, Kim-Hung; Lee, Kwee-Yum; Chang, Hyejin; Kim, Jaehi; Pham, Xuan‐Hung; Lee, Jun Young; Rho, Won‐Yeop; Jun, Bong‐Hyun

doi:10.1007/978-981-33-6158-4_10

Cited by 4 publications

(1 citation statement)

References 42 publications

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“…Huynh et al (2021) successfully synthesized and dendrimer-functionalized an NP to deliver the p53 tumor suppressor gene, which was administered locally at the tumor site. Results showed an improved antiproliferative effect compared to the free naked gene [ 72 ]. It was also demonstrated that dendrimers of the 3.5 generation loaded with cisplatin resulted in considerable accumulation in breast cancer cells [ 53 ].…”

Section: Pamam Dendrimersmentioning

confidence: 99%

Dendrimers as Modifiers of Inorganic Nanoparticles for Therapeutic Delivery in Cancer

2023

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The formulation of nanoscale systems with well-defined sizes and shapes is of great interest in applications such as drug and gene delivery, diagnostics and imaging. Dendrimers are polymers that have attracted interest due to their size, shape, branching length, amine density, and surface functionalities. These unique characteristics of dendrimers set them apart from other polymers, their ability to modify nanoparticles (NPs) for biomedical applications. Dendrimers are spherical with multiple layers over their central core, each representing a generation. Their amphiphilic nature and hollow structure allow for the incorporation of multiple drugs or genes, in addition to enabling easy surface modification with cellular receptor-targeting moieties to ensure site-specific delivery of therapeutics. Dendrimers are employed in chemotherapeutic applications for the delivery of anticancer drugs. There are many inorganic NPs currently being investigated for cancer therapy, each with their own unique biological, chemical, and physical properties. To favor biomedical applications, inorganic NPs require suitable polymers to ensure stability, biodegradability and target specificity. The success of dendrimers is dependent on their unique structure, good bioavailability and stability. In this review, we describe the properties of dendrimers and their use as modifiers of inorganic NPs for enhanced therapeutic delivery. Herein, we review the significant developments in this area from 2015 to 2022. Databases including Web of Science, Scopus, Google Scholar, Science Direct, BioMed Central (BMC), and PubMed were searched for articles using dendrimers, inorganic nanoparticles and cancer as keywords.

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Section: Pamam Dendrimersmentioning

confidence: 99%

Dendrimers as Modifiers of Inorganic Nanoparticles for Therapeutic Delivery in Cancer

2023

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Exploring treatment options in cancer: tumor treatment strategies

Liu,

Zhou,

Tan

et al. 2024

Sig Transduct Target Ther

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Traditional therapeutic approaches such as chemotherapy and radiation therapy have burdened cancer patients with onerous physical and psychological challenges. Encouragingly, the landscape of tumor treatment has undergone a comprehensive and remarkable transformation. Emerging as fervently pursued modalities are small molecule targeted agents, antibody-drug conjugates (ADCs), cell-based therapies, and gene therapy. These cutting-edge treatment modalities not only afford personalized and precise tumor targeting, but also provide patients with enhanced therapeutic comfort and the potential to impede disease progression. Nonetheless, it is acknowledged that these therapeutic strategies still harbour untapped potential for further advancement. Gaining a comprehensive understanding of the merits and limitations of these treatment modalities holds the promise of offering novel perspectives for clinical practice and foundational research endeavours. In this review, we discussed the different treatment modalities, including small molecule targeted drugs, peptide drugs, antibody drugs, cell therapy, and gene therapy. It will provide a detailed explanation of each method, addressing their status of development, clinical challenges, and potential solutions. The aim is to assist clinicians and researchers in gaining a deeper understanding of these diverse treatment options, enabling them to carry out effective treatment and advance their research more efficiently.

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Application of Nanomaterials to Enhance Polymerase Chain Reaction

et al. 2022

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Polymerase Chain Reaction (PCR) is one of the most common technologies used to produce millions of copies of targeted nucleic acid in vitro and has become an indispensable technique in molecular biology. However, it suffers from low efficiency and specificity problems, false positive results, and so on. Although many conditions can be optimized to increase PCR yield, such as the magnesium ion concentration, the DNA polymerases, the number of cycles, and so on, they are not all-purpose and the optimization can be case dependent. Nano-sized materials offer a possible solution to improve both the quality and productivity of PCR. In the last two decades, nanoparticles (NPs) have attracted significant attention and gradually penetrated the field of life sciences because of their unique chemical and physical properties, such as their large surface area and small size effect, which have greatly promoted developments in life science and technology. Additionally, PCR technology assisted by NPs (NanoPCR) such as gold NPs (Au NPs), quantum dots (QDs), and carbon nanotubes (CNTs), etc., have been developed to significantly improve the specificity, efficiency, and sensitivity of PCR and to accelerate the PCR reaction process. This review discusses the roles of different types of NPs used to enhance PCR and summarizes their possible mechanisms.

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Bioapplications of Nanomaterials

Cited by 4 publications

References 42 publications

Dendrimers as Modifiers of Inorganic Nanoparticles for Therapeutic Delivery in Cancer

Dendrimers as Modifiers of Inorganic Nanoparticles for Therapeutic Delivery in Cancer

Exploring treatment options in cancer: tumor treatment strategies

Application of Nanomaterials to Enhance Polymerase Chain Reaction

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