Bioapplications of hyperbranched polymers

Abstract

Hyperbranched polymers (HBPs), an important subclass of dendritic macromolecules, are highly branched, three-dimensional globular nanopolymeric architectures. Attractive features like highly branched topological structures, adequate spatial cavities, numerous terminal functional groups and convenient synthetic procedures distinguish them from the available polymers (the linear, branched, and crosslinking polymers). Due to their unique physical/chemical properties, applications of HBPs have been explored in a large variety of fields. In particular, HBPs exhibit unique advantages in the biological and biomedical systems and devices. Firstly, the way to prepare HBPs usually only involves simple one-pot reactions and avoids the complicated synthesis and purification procedures, which makes the manufacturing process more convenient, thus reducing production costs. Secondly, the large number of end-groups of HBPs provides a platform for conjugation of the functional moieties and can also be employed to tailor-make the properties of HBPs, enhancing their versatility in biological applications. Thirdly, HBPs possess excellent biocompatibility and biodegradability, controlled responsive nature, and ability to incorporate a multiple array of guest molecules through covalent or noncovalent approaches. All of these features of HBPs are of great significance for designing and producing biomaterials. To date, significant progress has been made for the HBPs in solving some of the fundamental and technical questions toward their bioapplications. The present review highlights the contribution of HBPs to biological and biomedical fields with intent to aid the researchers in exploring HBPs for bioapplications.

Tetraphenylethene-based highly emissive metallacage as a component of theranostic supramolecular nanoparticles

“…Nanoparticles (NPs) that are composed of polymers are emerging as a promising platform to develop personalized nanomedicines for diseaseand patient-specific diagnosis and treatment (18)(19)(20)(21)(22)(23). The ability to select given surface coatings and grow NPs of controllable size has an effect on the rate of clearance via circulation and immune response, such as the reticuloendothelial system (RES) located in the reticular connective tissue (24)(25)(26)(27). mPEG-DSPE and biotin-PEG-DSPE were used to incorporate 4 into MNPs whose terminal biotin groups would provide selective transport to cancer cells overexpressing biotin receptors (28).…”

Comparison of Loading Efficiency between Hyperbranched Polymers and Cross‐Linked Nanogels at Various Branching Densities

“…Nanostructured polymers that have branched topologies, large surface area, and empty interior volume are considered unimolecular containers for encapsulation, [1][2][3][4] protection, [ 5 ] and controlled release [ 6,7 ] of active "cargoes" [ 8 ] in applications of pharmaceuticals, [ 9,10 ] personal care [ 11 ] and catalysis. [ 12 ] So far, various types of unimolecular…”

Solubilization of phenols by multimolecular aggregates formed by low molecular weight hyperbranched polyglycidol

“…In this way, a number of active molecules can be conjugated to each unimolecular micelle reaching a high local concentration. These properties have prompted an increasing number of investigations to develop novel HBP for different kinds of applications [6][7][8][9][10].…”