Bioanalytical Study of the Effect of Lycopene on the Pharmacokinetics of Theophylline in Rats

Youssef, Reem Baha-Aldeen; Fouad, Marwa A.; El‐Zaher, Asmaa A.

doi:10.1007/s11094-020-02121-1

Cited by 2 publications

(1 citation statement)

References 25 publications

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“…На сегодняшний день оценка функционального состояния гепатобилиарной системы посредством анализа изменений клиренса экзогенного кофеина является одним из перспективнейших печёночных нагрузочных проб, что обусловлено его исключительным (97-98%) метаболизмом с задействием ферментной системой цитохрома Р-450 с образованием таких продуктов биотрансформации, как теобромин и теофиллин, которые, с точки зрения своих химических свойств, не определяются специфическими количественными и качественными кофеиновыми реакциями, что позволяет с высокой точностью дифференцировать уровни кофеина в биологических жидкостях и оценивать динамику его биотрансформации, которая существенно видоизменяется при наличии функциональных нарушений. Кофеин относительно быстро и в полном объёме достигает система кровотока независимо от способа введения, имеет низкое связывание с плазмой, а также короткий период полувыведения, отличную переносимость (при условии контроля его влияния на сердечно-сосудистую систему), и его биотрансформация практически ограничивается печенью [1,2,3,4,5,6].…”

Section: введение / Introductionunclassified

Pharmacokinetic parameters of caffeine in laboratory animals in the context of assessing the functional state of the liver.

Popova,

Ponamarev,

Kostrova

et al. 2023

jour

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To date, the assessment of the functional state of the hepatobiliary system by analyzing changes in the clearance of exogenous caffeine is one of the most promising hepatic stress tests. The purpose of the study was to establish the pharmacokinetic change in the levels of exogenous caffeine in the blood plasma of laboratory animals in order to further induce various liver pathologies and subsequently assess the change in its clearance. For the study, non-linear laboratory rats were used (18 males, 18 females, average live weight 180 g ± 4%, age 3 months), Of the experimental animals, 3 groups were formed (6 females and 6 males each), each of which was injected subcutaneously with a 20% solution of caffeine sodium benzoate (Mosagrogen LLC, Russia) in increments of 50 mg/kg (50, 100, 150) in terms of pure caffeine.When using dosages of 100 and 150 mg/ kg, we noted a non-linear biotransformation of the test substance, namely, peak concentrations 4 hours after administration, which is also a standard pharmacokinetic indicator for dosages passing along the upper limit of the therapeutic latitude of the drug and is due to the fact that that at such dosages, the cytochrome P-450 enzyme system does not differ in reactivity compared to the absorption time of the substance.As a result of the experiment, we established the initial and peak levels of caffeine for further study of its changes during the artificial induction of hepatopathy of various origins in a specific experimental group of laboratory animals. We also noted the absence of dependence on the sex of the listed levels, and such results are consistent with the data obtained by other researchers.

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Section: введение / Introductionunclassified

Pharmacokinetic parameters of caffeine in laboratory animals in the context of assessing the functional state of the liver.

Popova,

Ponamarev,

Kostrova

et al. 2023

jour

View full text Add to dashboard Cite

show abstract

A Structural Analysis of Proteinaceous Nanotube Cavities and Their Applications in Nanotechnology

Heide

Stetefeld

2022

Nanomaterials

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Protein nanotubes offer unique properties to the materials science field that allow them to fulfill various functions in drug delivery, biosensors and energy storage. Protein nanotubes are chemically diverse, modular, biodegradable and nontoxic. Furthermore, although the initial design or repurposing of such nanotubes is highly complex, the field has matured to understand underlying chemical and physical properties to a point where applications are successfully being developed. An important feature of a nanotube is its ability to bind ligands via its internal cavities. As ligands of interest vary in size, shape and chemical properties, cavities have to be able to accommodate very specific features. As such, understanding cavities on a structural level is essential for their effective application. The objective of this review is to present the chemical and physical diversity of protein nanotube cavities and highlight their potential applications in materials science, specifically in biotechnology.

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Bioanalytical Study of the Effect of Lycopene on the Pharmacokinetics of Theophylline in Rats

Cited by 2 publications

References 25 publications

Pharmacokinetic parameters of caffeine in laboratory animals in the context of assessing the functional state of the liver.

Pharmacokinetic parameters of caffeine in laboratory animals in the context of assessing the functional state of the liver.

A Structural Analysis of Proteinaceous Nanotube Cavities and Their Applications in Nanotechnology

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