Bioanalytical methods for cytostatic therapeutic drug monitoring and occupational exposure assessment

Broto, Marta; Galvé, Roger; Marco, M.‐Pilar

doi:10.1016/j.trac.2017.05.005

Cited by 18 publications

(10 citation statements)

References 100 publications

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“…Studies showed a wide gap between nurses' professional knowledge and practice in the area of using personal protective equipment. [ 10 11 ] Therefore, continuing education programs, active encouragement for adhering to safety standards, and correcting unsafe approaches to care delivery can help create a safe environment for nurses. [ 40 ]…”

Section: Discussionmentioning

confidence: 99%

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Oncology Nurses' Needs Respecting Healthy Work Environment in Iran: A Descriptive Exploratory Study

Soheili

Taleghani

Jokar

et al. 2021

Asia-Pacific Journal of Oncology Nursing

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Objective: The work environment of oncology nurses is often unpleasant due to the complexities of cancer treatment and care. Yet, there is limited information about their perspectives on healthy work environment (HWE) and their HWE-related needs. This study aimed to explore oncology nurses' HWE-related needs. Methods: This descriptive exploratory qualitative study was conducted in 2018–2019. Participants were 52 nurses and 11 oncology specialists, nursing instructors and managers, and occupational and environmental health experts, who had the experience of promoting nurses' work conditions. They were recruited from eight teaching specialty cancer treatment centers in different cities of Iran (Tehran, Isfahan, Mashhad, Shiraz, and Babolsar). Data were collected via semi-structured interviews. Data were analyzed via conventional content analysis. Results: Oncology nurses' HWE-related needs were grouped into the four main categories of physical–structural improvement, mental health improvement in work environment, organizational improvement, and sociocultural improvement. Conclusions: A wide range of physical–structural, mental health, organizational, and sociocultural improvements should be made to oncology nurses' work environment in order to fulfill their HWE-related needs. Health-care managers can use the findings of the present study to create HWE for oncology nurses.

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Section: Discussionmentioning

confidence: 99%

“…[ 7 8 9 ] They also face occupational safety hazards due to their exposure to chemotherapy agents. [ 10 11 ]…”

Section: Introductionmentioning

confidence: 99%

Oncology Nurses' Needs Respecting Healthy Work Environment in Iran: A Descriptive Exploratory Study

Soheili

Taleghani

Jokar

et al. 2021

Asia-Pacific Journal of Oncology Nursing

View full text Add to dashboard Cite

show abstract

“…[ 4 10 11 ] These nurses also face occupational safety hazards due to their exposure to chemotherapy agents. [ 12 13 ] In fact, workplace deficiencies and challenges in caring for cancer patients can put additional physical, psychological, and spiritual strains on nurses. [ 14 ]…”

Section: Introductionmentioning

confidence: 99%

Exploring the occupational health needs of oncology nurses

Soheili

Jokar

Eghbali-Babadi

et al. 2021

Journal of Education and Health Promotion

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BACKGROUND: Although the work environment of oncology nurses is highly complex and challenging, their occupational health needs are scarcely studied. This study aimed to explore the occupational health needs of oncology nurses. MATERIALS AND METHODS: This qualitative descriptive study was conducted in 2018–2019. The participants consisted of 52 oncology nurses and 11 other key informants. They were chosen from eight cancer treatment centers in different cities of Iran. Data were collected through semi-structured individual interviews and analyzed using conventional content analysis. RESULTS: The occupational health needs of oncology nurses were grouped into three main categories included needs for self-care, development of professional competency, and a safe and healthy work environment. CONCLUSION: The work environment of oncology nurses needs to be optimized in terms of physical, psychological, organizational, and sociocultural conditions. Furthermore, the necessary measures should be taken to encourage oncology nurses to implement self-care, thus creating the preparedness to face the challenges of the workplace by developing their professional competencies.

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“…Therefore, controlled drug release is a critical technology for personalized medicine (Schork, 2015). Moreover, therapeutic drug monitoring can be used to attain full therapeutic efficacy with minimum toxicity and side effects (Broto, Galve, & Marco, 2017). Pharmacokinetic analyses have revealed that many drugs have a small therapeutic window; exceeding drug dosages may produce adverse responses, whereas smaller drug amounts would be insufficient for treatment (Kiang, Ranamukhaarachchi, & Ensom, 2017; Tamargo, Le Heuzey, & Mabo, 2015).…”

Section: Introductionmentioning

confidence: 99%

Pixel‐based drug release system: Achieving accurate dosage and prolonged activity for personalized medicine

2020

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We have developed a pixel‐based drug release system that consists of several miniature drug cartridges capable of releasing accurate dosages and maintaining the drug within a therapeutic window. To achieve the goal of personalized medicine that takes into account targeted dosages, single or multiple miniature cartridges can be used to release the drug. Moreover, a release cascade with individual pixels in a time‐lag fashion can maintain the drug within the therapeutic window while prolonging its duration of activity. For high quality, dosage control, and precise administration, the amount of drug released from each miniature cartridge needs to be predicted accurately. As such, the total released amount over a specific time and the number of involved miniature cartridges can be optimized. We established a model based on analogizing our voltage‐triggered drug release system to capacitors, and mathematically determined the amount of release from every miniature cartridge. The model predicted that the procedure can be fitted using an exponential function. The characteristic time for the exponential fit was used to derive the predicting formula to be calibrated for each drug. We have shown that after calibration, the release of each miniature cartridge with different drugs and various initial loads can be predicted; therefore, a dosage release can be achieved based on each patient's need.

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Bioanalytical methods for cytostatic therapeutic drug monitoring and occupational exposure assessment

Cited by 18 publications

References 100 publications

Oncology Nurses' Needs Respecting Healthy Work Environment in Iran: A Descriptive Exploratory Study

Oncology Nurses' Needs Respecting Healthy Work Environment in Iran: A Descriptive Exploratory Study

Exploring the occupational health needs of oncology nurses

Pixel‐based drug release system: Achieving accurate dosage and prolonged activity for personalized medicine

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