Abstract:Background:
The number of validated quantification methods for rifampicin, a prototypical Oatp inhibitor, in biological rat samples was limited.
Objective:
This study was conducted to validate a modified reversed-phase liquid chromatographic method for the determination of rifampicin in rat liver tissue according to the current ICH M10 Bioanalytical Method Validation Draft Guideline (2019) for application to samples of in situ rat liver perfusion studies.
Method:
Liver tissue samples were obtained from … Show more
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